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Allergy & Rhinology (1)
The American Journal of Case Reports (1)
Fukushima, Chizu (2)
Kawano, Tetsuya (2)
Kohno, Shigeru (2)
Matsuse, Hiroto (2)
Tsuchida, Tomoko (2)
Fukahori, Susumu (1)
Hayashi, Tomayoshi (1)
Hirose, Hiroko (1)
Kinoshita, Naoe (1)
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Tomari, Shinya (1)
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Bronchoscopic observation of unusual deformities of bronchial cartilage and subsequent airway narrowing in respiratory relapsing polychondritis
The American Journal of Case Reports
Relapsing polychondritis (RP) is a rare inflammatory disease characterized by recurrent chondritis and inflammation of other proteoglycan-rich tissues. An RP patient with co-existing respiratory tract problems could have a poor prognosis.
We reported a case of RP died with recurrent suffocation. At the early stage in this case, unusual deformities of bronchial cartilage were observed. Following systemic corticosteroid therapy, these deformities disappeared, and typical diffuse mucosal edema and dynamic collapse of airways developed.
These bronchoscopic abnormalities could be the early stage of RP.
relapsing polychondritis; suffocation; deformity of bronchial cartilage
Regulation of dendritic cell functions against harmful respiratory pathogens by a cysteinyl leukotrienes receptor antagonist
Allergy & Rhinology
Cysteinyl leukotriene receptor antagonist (LTRA) is a widely used medicine for asthma. Cysteinyl leukotrienes (cysLTs) are involved in the regulation of dendritic cell (DC) function. However, the effects of LTRA on DC-related antimicrobial immunity against harmful respiratory pathogens remain unknown. The purpose of this study was to examine the effects of LTRA administered in vivo on DC function against representative respiratory pathogens in vitro. Pulmonary DCs were isolated from four groups of mice: control, mite allergen sensitized (AS), and AS mice treated with the corticosteroid dexamethasone (Dex) or with the LTRA pranlukast (Prl). These DCs were incubated with mite allergen, lipopolysaccharide (LPS), Aspergillus fumigatus, or respiratory syncytial virus (RSV). IL-10 and IL-12 production was then determined. Dex treatment significantly inhibited lipopolysaccharide (LPS)-induced IL-10 and IL-12 production as well as baseline IL-12 production in AS mice. The Prl did not significantly inhibit LPS-induced IL-10 and IL-12 production in AS mice. More importantly, Prl significantly increased IL-10 and IL-12 in AS mice after RSV infection. This study shows that LTRA that is used for asthma potentially up-regulates antimicrobial immunity through modulation of DC function against some respiratory infections without immunosuppression.
Allergic airway inflammation; Aspergillus fumigatus; asthma; corticosteroids; cysteinyl leukotrienes receptor antagonist; cytokines; dendritic cell; Dermatophagoides farinae; lipopolysaccharide; respiratory syncytial virus
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