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Scientific Reports (1)
Tay, Francis Eng Hock (2)
Chen, Shuting (1)
Gruber, Jan (1)
Jenner, Andrew M. (1)
Liew, Weng Heng (1)
Mirshekarloo, Meysam Sharifzadeh (1)
Ruan, Runsheng (1)
Wong, Yee Ting (1)
Yao, Kui (1)
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Nanoconfinement induced crystal orientation and large piezoelectric coefficient in vertically aligned P(VDF-TrFE) nanotube array
Liew, Weng Heng
Mirshekarloo, Meysam Sharifzadeh
Vertically aligned piezoelectric P(VDF-TrFE) nanotube array comprising nanotubes embedded in anodized alumina membrane matrix without entanglement has been fabricated. It is found that the crystallographic polar axes of the P(VDF-TrFE) nanotubes are oriented along the nanotubes long axes. Such a desired crystal orientation is due to the kinetic selection mechanism for lamellae growth confined in the nanopores. The preferred crystal orientation in nanotubes leads to huge piezoelectric coefficients of the P(VDF-TrFE). The piezoelectric strain and voltage coefficients of P(VDF-TrFE) nanotube array are observed to be 1.97 and 3.40 times of those for conventional spin coated film. Such a significant performance enhancement is attributed to the well-controlled polarization orientation, the elimination of the substrate constraint, and the low dielectric constant of the nanotube array. The P(VDF-TrFE) nanotube array exhibiting the unique structure and outstanding piezoelectric performance is promising for wide applications, including various electrical devices and electromechanical sensors and transducers.
Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice
Wong, Yee Ting
Jenner, Andrew M.
Thymic involution and shrinkage of secondary lymphoid organs are leading causes of the deterioration of the T-cell compartment with age. Inflamm-aging, a sustained inflammatory status has been associated with chronic diseases and shortened longevity. This is the first study to investigate the effect of treating aging hybrid mice with long-term, low-dose resveratrol (RSV) in drinking water by assessing multiple immunological markers and profiles in the immune system. We found that hybrid mice exhibited marked age-related changes in the CD3+CD4+, C3+CD8+, CD4+CD25+, CD4M and CD8M surface markers. RSV reversed surface phenotypes of old mice to that of young mice by maintaining the CD4+ and CD8+ population in splenocytes as well as reducing CD8+CD44+ (CD8M) cells in the aged. RSV also enhanced the CD4+CD25+ population in old mice. Interestingly, pro-inflammatory status in young mice was transiently elevated by RSV but it consequently mitigated the age-dependent increased pro-inflammatory cytokine profile while preserving the anti-inflammatory cytokine condition in the old mice. Age-dependent increase in 8OHdG, an oxidative DNA damage marker was ameliorated by RSV. Immunological-focused microarray gene expression analysis showed that only the CD72 gene was significantly downregulated in the 12-month RSV-treated mice compared to age-matched controls. Our study indicates that RSV even at low physiological relevant levels is able to affect the immune system without causing marked gene expression changes.
Resveratrol; Aging; Cytokines; Inflammation; Oxidative DNA damage; T lymphocytes; Surface markers
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