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Evidence-based Complementary and Alternative Medicine : eCAM (1)
Revista do Instituto de Medicina Tropical de São Paulo (1)
ACOSTA-VIANA, Karla Y. (1)
AGUILAR-CABALLERO, Armando J. (1)
Acosta-Viana, Karla Y. (1)
GUZMAN-MARIN, Eugenia del S. (1)
Guzman-Marin, Eugenia (1)
HERNÁNDEZ-CORTAZAR, Ivonne (1)
JIMÉNEZ-COELLO, Matilde (1)
Jimenez-Coello, Matilde (1)
ORTEGA-PACHECO, Antonio (1)
Ortega-Pacheco, Antonio (1)
Perez-Gutierrez, Salud (1)
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TOXOPLASMOSIS IN MEXICO: EPIDEMIOLOGICAL SITUATION IN HUMANS AND ANIMALS
ACOSTA-VIANA, Karla Y.
AGUILAR-CABALLERO, Armando J.
Revista do Instituto de Medicina Tropical de São Paulo
Toxoplasmosis is a parasitic disease widely distributed throughout the world, infecting a wide variety of animal species including humans. In Mexico, this parasite has been detected in different parts of the country, particularly in the tropical areas where the parasite can remain infective for long periods of time due to the environmental conditions (i.e. high temperature and humidity over the whole year). Several epidemiological studies have been conducted in both human and animal populations, but despite the wide distribution of the agent in the country, there is a significant lack of knowledge on the parasite transmission, treatment alternatives and control measures. The lack of feral cat populations and control measures in sites of meat production for human consumption are playing a role that has led to the wide spread of the disease in the country, particularly in tropical areas of Southeastern Mexico. For these reasons, this manuscript aims to review the published information on relevant epidemiological aspects of infection with T. gondii in humans and animals from Mexico.
Toxoplasmosis; Neglected disease; Mexico; Endemic; Zoonosis
In Vivo Antiprotozoal Activity of the Chloroform Extract from Carica papaya Seeds against Amastigote Stage of Trypanosoma cruzi during Indeterminate and Chronic Phase of Infection
Acosta-Viana, Karla Y.
Evidence-based Complementary and Alternative Medicine : eCAM
In order to evaluate the antiprotozoal activity of the chloroform extract of Carica papaya seeds during the subacute and chronic phase of infection of Trypanosoma cruzi, doses of 50 and 75 mg/kg were evaluated during the subacute phase, including a mixture of their main components (oleic, palmitic, and stearic acids). Subsequently, doses of 50 and 75 mg/kg in mice during the chronic phase of infection (100 dpi) were also evaluated. It was found that chloroform extract was able to reduce the amastigote nests numbers during the subacute phase in 55.5 and 69.7% (P > 0.05) as well as in 56.45% in animals treated with the mixture of fatty acids. Moreover, the experimental groups treated with 50 and 75 mg/kg during the chronic phase of the infection showed a significant reduction of 46.8 and 53.13% respectively (P < 0.05). It is recommended to carry out more studies to determine if higher doses of chloroformic extract or its administration in combination with other antichagasic drugs allows a better response over the intracellular stage of T. cruzi in infected animal models and determine if the chloroform extract of C. papaya could be considered as an alternative for treatment during the indeterminate and chronic phase of the infection.
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