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Advances in Virology (1)
Developmental biology (1)
Gaston, David C. (2)
Benjamin, John T. (1)
Cassady, Kevin A. (1)
Halloran, Brian A. (1)
Markert, James M. (1)
Odom, Carl I. (1)
Prince, Lawrence S. (1)
Schnapp, Lynn M. (1)
Zent, Roy (1)
Year of Publication
Human Herpesviridae Methods of Natural Killer Cell Evasion
Odom, Carl I.
Markert, James M.
Cassady, Kevin A.
Advances in Virology
Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. These methods include interference with the ligands on infected cell surfaces that bind NK cell activating or inhibitory receptors. This paper summarizes the most extensively studied NK cell receptor/ligand pairs and then describes the methods of NK cell evasion used by all eight herpesviruses through these receptors and ligands. Although great strides have been made in elucidating their mechanisms, there is still a disparity between viruses in the amount of knowledge regarding innate immune evasion. Further research of herpesvirus innate immune evasion can provide insight for circumventing viral mechanisms in future therapies.
The role of integrin α8β1 in fetal lung morphogenesis and injury
Benjamin, John T.
Halloran, Brian A.
Schnapp, Lynn M.
Prince, Lawrence S.
Prenatal inflammation prevents normal lung morphogenesis and leads to bronchopulmonary dysplasia (BPD), a common complication of preterm birth. We previously demonstrated in a bacterial endotoxin mouse model of BPD that disrupting fibronectin localization in the fetal lung mesenchyme causes arrested saccular airway branching. In this study we show that expression of the fibronectin receptor, integrin α8β1, is decreased in the lung mesenchyme in the same inflammation model suggesting it is required for normal lung development. We verified a role for integrin α8β1 in lung development using integrin α8-null mice, which develop fusion of the medial and caudal lobes as well as abnormalities in airway division. We further show in vivo and vitro that α8-null fetal lung mesenchymal cells fail to form stable adhesions and have increased migration. Thus we propose that integrin α8β1 plays a critical role in lung morphogenesis by regulating mesenchymal cell adhesion and migration. Furthermore, our data suggests that disruption of the interactions between extracellular matrix and integrin α8β1 may contribute to the pathogenesis of BPD.
lung development; branching morphogenesis; cell-matrix interactions; cell migration; fibronectin
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