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1.  Synthesis, Characterization, and Biological Evaluation of Some New Functionalized Terphenyl Derivatives 
New functionalized terphenyl derivatives incorporating various heterocyclic rings are prepared by using 4,4′′-difluoro-5′-hydroxy-1,1′:3′,1′′-terphenyl-4′-carbohydrazide as a key intermediate derived from 4,4′-difluoro chalcone, a versatile synthone. All the derivatives are characterized by 1H NMR, IR, and mass spectral data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. The majority of the tested compounds exhibited significant antioxidant activity and some of them showed good antimicrobial activity.
PMCID: PMC4207451  PMID: 25379286
2.  2-Chloro-1-(4-hy­droxy­phen­yl)ethanone 
The asymmetric unit of the title compound, C8H7ClO2, consists of two independent mol­ecules, with comparable geometries. Both mol­ecules are approximately planar (r.m.s. deviations = 0.040 and 0.064 Å for the 11 non-H atoms). In the crystal, mol­ecules are linked via inter­molecular O—H⋯O and C—H⋯O hydrogen bonds into chains two mol­ecules thick along (-101).
PMCID: PMC3414342  PMID: 22904875
3.  N′-[(E)-4-Chloro­benzyl­idene]pyridine-4-carbohydrazide monohydrate 
The asymmetric unit of the title compound, C13H10ClN3O·H2O, consists of two crystallographically independent Schiff base mol­ecules which exist in an E conformation with respect to the C=N double bond, and two independent water mol­ecules. In the crystal, the Schiff base and water mol­ecules are linked into a three-dimensional network via N—H⋯O, O—H⋯N, O—H⋯O and C—H⋯O hydrogen bonds. The crystal studied was a pseudo-merohedral twin with twin law (101 0-10 00-1) and a component ratio of 0.792 (2):0.208 (2).
PMCID: PMC3394078  PMID: 22798943
4.  N′-(2,6-Difluoro­benzyl­idene)pyridine-4-carbohydrazide 
In the title compound, C13H9F2N3O, the pyridine ring forms a dihedral angle of 16.92 (7)° with the benzene ring. In the crystal, mol­ecules are linked via N—H⋯O, C—H⋯O and C—H⋯F, with the same O atom accepting two bonds.
PMCID: PMC3344594  PMID: 22590356
5.  4-Methyl­benzoic acid–N′-[(E)-4-methyl­benzyl­idene]pyridine-4-carbohydrazide–water (1/1/1) 
In the title hydrated 1:1 adduct, C8H8O2·C14H13N3O·H2O, the Schiff base mol­ecule exists in an E conformation with respect to the N=C bond [1.2843 (13) Å] and the dihedral angle between the pyridine ring and the benzene ring is 1.04 (5)°. In the crystal, mol­ecules are linked by N—H⋯O, C—H⋯O, O—H⋯O and O—H⋯N hydrogen bonds into sheets lying parallel to the ab plane. The crystal structure also features π–π inter­actions with centroid–centroid distances of 3.6224 (6) and 3.7121 (6) Å.
PMCID: PMC3344602  PMID: 22590364
6.  N-(3-Chloro-4-fluoro­phen­yl)acetamide 
In the title compound, C8H7ClFNO, the dihedral angle between the benzene ring and the acetamide side chain is 5.47 (6)°. An S(6) ring motif is formed via an intra­molecular C—H⋯O hydrogen bond. In the crystal, N—H⋯O hydrogen bonds link the mol­ecules into C(4) chains along [001].
PMCID: PMC3344482  PMID: 22590244
7.  4-[(4-Benzyl­oxybenzyl­idene)amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one 
In the title mol­ecule, C25H23N3O2, two terminal phenyl rings are twisted by 50.20 (6) and 71.26 (5)° from the mean plane (r.m.s. deviation = 0.032 Å) of the central benzyl­idene–amino–pyrazolone fragment. The N atoms of the pyrazole ring have a pyramidal environment, the sums of the valence angles around them being 353.5 (2) and 347.3 (2)°. The crystal structure is stabilized by C—H⋯O interactions.
PMCID: PMC3344463  PMID: 22590225
8.  4-(3-Carb­oxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-7-quinol­yl)-1-methyl­piper­azin­ium picrate 
The pefloxacinium cation of the title salt, C17H21FN3O3 +·C6H2N3O7 −, is composed of an essentially planar quinoline ring system [maximum deviation = 0.021 (2) Å] and a piperazine ring, which adopts a chair conformation. In the picrate anion, the two O atoms of one of the o-NO2 groups are disordered over two positions, with an occupancy ratio of 0.56 (4):0.44 (4). In the crystal structure, cations and anions are connected by inter­molecular N—H⋯O, O—H⋯O, C—H⋯O and C—H⋯F hydrogen bonds, forming a three-dimensional network. In addition, π–π inter­actions between the pyridine rings and between the benzene rings of the anions, with centroid–centroid distances of 3.6103 (12) and 3.5298 (11) Å, respectively, are observed.
PMCID: PMC2983575  PMID: 21580452

Results 1-8 (8)