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ARYA Atherosclerosis (1)
Indian Journal of Dermatology (1)
International Journal of Preventive Medicine (1)
Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences (1)
Najafian, Jamshid (4)
Naeini, Farahnaz Fatemi (2)
Fahimipour, Farinaz (1)
Fatemi Naeini, Farahnaz (1)
Jazebi, Noushin (1)
Mohammadifard, Noushin (1)
Nilforoushzadeh, Mohammadali (1)
Nouri, Fatemeh (1)
Shahmoradi, Zabihollah (1)
Toghianifar, Nafiseh (1)
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CD30+ Large Cell Transformation of Mycosis Fungoides During Pregnancy
Naeini, Farahnaz Fatemi
Indian Journal of Dermatology
Mycosis fungoides (MF) a cutaneous T-cell lymphoma, is a subgroup of non-Hodgkin's lymphomas, characterized by skin infiltration and occasionally systemic involvement. MF coincidence with pregnancy is rare. The effect of pregnancy on MF and the effect of this disease on pregnancy are still unknown. There are few case reports about pregnancy and its deleterious effect on the clinical course of MF. This case report is about a 30-years-old female with MF who became pregnant and after delivery developed CD30+ large cell transformation; this is the first report of large cell transformation of MF related to pregnancy.
Mycosis fungoides; pregnancy; large cell transformation
Vitiligo and Autoantibodies of Celiac Disease
Naeini, Farahnaz Fatemi
International Journal of Preventive Medicine
Vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. The exact etiology and pathogenesis of vitiligo is not clear. Many theories have been presented regarding this subject among them aautoimmune theory is the most important one. The association of vitiligo with other autoimmune disorders has been reported, but the relationship between vitiligo and celiac disease is controversial. The aim of this study was to study the frequency of celiac autoantibodies in a group of vitiligo patients compared with control.
This was a cross sectional case control study that involved 128 individuals, 64 vitiligo patients and 64 individuals as control group. The means age of participants was 30.3 ± 14.4 years. IgA anti Endomysial antibody and IgA anti-glutaminase antibody were measured by ELISA method in the serum of all participants. Data were analyzed by SPSS software version 15.
The serum of two vitiligo patients (3.1%) was positive for antibodies. All control groups were seronegative for these antibodies (P < 0.05). There was no significant effect of sex and job on seropositivity.
There may be a relationship between celiac disease and vitiligo. This may indicate a common basic autoimmune mechanism that is an explanation for few case reports that gluten free diets were effective in the treatment of vitiligo patients. Both T test and exact fisher test showed no effect of age, sex and job on seropositivity of these patients (P = 0.56 and P = 0.74, respectively)
Autoantibodies; celiac disease; gluten free diet; vitiligo
Hirsutism and body mass index in a representative sample of Iranian people
Fatemi Naeini, Farahnaz
Hirsutism is the condition of excessive terminal hair growth in women with a typical male pattern distribution. Hirsutism is a common disorder that affects about 5% -10% of women of reproductive age. Adipose tissue contributes up to 50% of the circulating testosterone in premenopausal women Because of excessive androgen production in fat tissue. Therefore, it seems that hirsutism must be more common in people with simple obesity but controversy exist regarding this subject. The aim of this study is to evaluate the relation between Body Mass Index and hirsutism in a representative sample of Iranian woman.
This is a cross sectional case control clinical trial. The study involved 800 individuals; 400 hirsute females and 400 healthy women as control group. The mean age of the participants was 28 ± 6.2 years. Hirsutism was determined by the Ferriman-Gallwey scoring system. Height and weight were measured by a Seca scale, Body Mass Index was calculated as weight/height² (kg/m²), and collected data were analyzed by SPSS software version 18 using T-test and chi-square statistical test.
There were no significant differences between the two groups regarding age and height. However, Body Mass Index and weight were significantly higher in the case group than the control group. The chi square test revealed significant differences between the case and control groups regarding Body Mass Index (P < 0.001).
In the current study hirsutism was more common in patients with a higher Body Mass Index. The increased frequency of hirsutism in overweight women could be explained by increased insulin resistance and more androgen production by adipose tissue.
Body Mass Index; Hirsutism; Obesity
Association between sleep duration and metabolic syndrome in a population-based study: Isfahan Healthy Heart Program
Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences
Recent epidemiologic studies have found that self-reported sleep duration is associated with components of metabolic syndrome (MS) such as obesity, diabetes and hypertension. This relation may be under influence of regional factors in different regions of the world. The association of sleep duration and MS in a sample of Iranian people in the central region of Iran was investigated in this study.
This cross-sectional study was conducted as a part of the Isfahan Healthy Heart Program (IHHP). A total of 12492 individuals aged over 19 years, 6110 men and 6382 women entered the study. Definition of National Cholesterol Education Program was used to define MS. Sleep duration was reported by participants. Relation between sleep duration with MS was examined using categorical logistic regression in two models; unadjusted and adjusted for age and sex.
In our study, 23.5 % of participants had MS. Compared with sleep duration of 7-8 hours per night; sleep duration of less than 5 hours was associated with a higher odds ratio for MS. This association remained significant even after adjustment for age and sex (OR: 1.52; 95%CI: 1.33-1.74). However, sleep duration of 9 hours or more showed a protective association with MS (OR: 0.79; 95%CI: 0.68-0.94).
There was a positive relation between sleep deprivation and MS and its components. This relation was slightly affected by sex and age.
Sleep; Metabolic Syndrome; Heart; Population
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