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1.  The relation between body iron store and ferritin, and coronary artery disease 
ARYA Atherosclerosis  2014;10(1):32-36.
Iron is essential for many physiological processes; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the importance of serum ferritin levels, which are known as an indicator of body iron stored in the incidence of coronary artery disease (CAD).
In a case-control study, we evaluated 432 eligible men who underwent coronary angiography at Chamran Cardiology Hospital, Isfahan, Iran. They were separated into two groups of case (with CAD) and control (without CAD). All subjects had given written informed consents. Then, the blood samples were taken after 12-14 hours of fast by a biologist for measuring cardiovascular risk factors and body iron stores, including serum ferritin, serum iron, and total iron binding capacity (TIBC). For statistical analyses, chi-square test, Student’s t-test, one-way ANOVA, and the logistic regression were used.
In the present study, 212 participants with CAD in the case group and 220 participants free of CAD in the control group were included in the analysis. At baseline, there were significant differences in serum ferritin (P < 0.001) and other cardiovascular risk factors between the two groups. Moreover, when other risk factors of CVD were included in the model, serum ferritin [Odd Ratio (OR) = 1.006, 95% confidence interval of 95% (95% CI) 1.00-1.01, P = 0.045] and serum ferritin ≥ 200 (OR = 4.49, 95% CI 1.72-11.70, P < 0.001) were associated with CAD.
High iron store, as assessed by serum ferritin, was associated with the increased risk of CAD. Furthermore, it was a strong and independent risk factor in the incident of atherosclerosis in the Iranian male population.
PMCID: PMC4063519  PMID: 24963311
Iron; Ferritin; Coronary Artery Disease; Coronary Angiography
2.  Comparing the effects of a cardiac rehabilitation program on functional capacity of obese and non-obese women with coronary artery disease 
ARYA Atherosclerosis  2012;8(2):55-58.
Obesity and sedentary lifestyle are known as important risk factors of coronary artery disease. The prevalence of obesity has increased among both men and women in the world. Therefore, the present study tried to evaluate the effectiveness of a cardiac rehabilitation program on functional capacity and body mass index (BMI) in obese and non-obese women with coronary artery disease.
In an observational study during 2000-11, we evaluated a total of 205 women with coronary artery disease who referred to the cardiac rehabilitation unit of Isfahan Cardiovascular Research Institute, Isfahan, Iran. BMI and functional capacity of each patient were assessed before and after the program. The patients were categorized as obese or non-obese based on their BMI. All participants completed the full course of the program. Data was analyzed by independent t-test and paired t-test in SPSS15.
Our finding showed that an 8-week cardiac rehabilitation program had significant effects on functional capacity in obese and non-obese female patients (P < 0.01 for both). The program also resulted in BMI improvements in both groups (P < 0.01 for both). Comparing the changes in the two groups did not reveal any significant differences in functional capacity. However, the two groups were significantly different in terms of BMI changes.
Cardiac rehabilitation programs are a major step in restoration of functional capacity and improvement of BMI in obese and non-obese women with coronary artery disease.
PMCID: PMC3463993  PMID: 23056103
Cardiac Rehabilitation Program; Coronary Artery Disease; Obesity; Functional Capacity; Body Mass Index
3.  Comparison the Effect of One Session Submaximal Exercise on Plasma Levels of IL6 and TNF- a in Obese and Non-Obese Women 
ARYA Atherosclerosis  2011;6(4):153-156.
Cytokines are a group of low-molecular-weight regulatory proteins that produced by cells in response to stimulation. In fact, they increase in response to immune system during exercise. Also, many cytokines such as IL-6 and TNFα are secreted from adipose tissue in obese people. So the aim of this study was to investigate the effect of one session submaximal exercise on plasma levels of IL6 and TNFα in obese and non-obese women.
Sixteen healthy women aged 20-30 years old participated in the study. Subjects were classified into obese (n=8) and nonobese (n=8) groups who performed submaximal exercise program (50-65% HRM) for 30minutes. Blood samples were taken for cytokines measurement, before and after exercise. Data were analyzed with SPSS15. The effect of exercise on mentiones variables was evaluated using t-test and covariance test.
Level of IL-6 increased significantly in two studied groups after 30 minutes submaximal exercise (P<0.05). Levels of TNFα increased significantly in obese subjects but not in non-obese subjects. There were no significant changes in the levels of IL-6 and TNFα after 30 minutes submaximal exercise between two studied groups (P>0.05).
After submaximal exercise, plasma level of IL6 and TNFα may increase and adipose tissue is the main source of circulating IL6 and TNFα.
PMCID: PMC3347828  PMID: 22577435
Submaximal Exercise; IL6; TNFα; Obese; Women

Results 1-3 (3)