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AAPS PharmSciTech (2)
AAPS PharmSci (1)
Tayade, Pralhad T. (2)
Bhimte, Nitin A. (1)
Kale, Rajendrakumar D. (1)
Modi, Aftab (1)
Tayade, Pralhad (1)
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author:("tayside, ralhan T.")
Evaluation of microcrystalline cellulose prepared from sisal fibers as a tablet excipient: A technical note
Bhimte, Nitin A.
The above data demonstrated that MCC derived from sisal fibers could be an industrially feasible alternative for currently used MCCs as diluent and disintegrant for both immediate-release as well as sustained-release oral solid dosage forms.
Microcrystalline cellulose; sisal fibers; disintegrant; diluent; scanning electron microscopy; x-ray diffractometry; dissolution
Enhancement of dissolution profile by solid dispersion (kneading) technique
This article investigates enhancement of the dissolution profile of valdecoxib using solid dispersion with PVP. The article also describes the preparation of fast-dissolving tablets of valdecoxib by using a high amount of superdisintegrants. A phase solubility method was used to evaluate the effect of various water-soluble polymers on aqueous solubility of valdecoxib. Polyvinyl pyrrolidone (PVP K-30) was selected and solid dispersions were prepared by the method of kneading. Dissolution studies, using the USP paddle method were performed for solid dispersions of valdecoxib. Infrared (IR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with commercial products. IR spectroscopy, XRD, and DSC showed no change in the crystal structure of valdecoxib. Dissolution of valdecoxib improved significantly in solid dispersion products (<85% in 5 minutes). Tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of valdecoxib.
Solid dispersion; valdecoxib; dissolution enhancement; fast-dissolving tablets
Encapsulation of water-insoluble drug by a cross-linking technique: Effect of process and formulation variables on encapsulation efficiency, particle size, and in vitro dissolution rate
Kale, Rajendrakumar D.
Ibuprofen-gelatin micropellets were prepared by the cross-linking technique using formaldehyde. Spherical micropellets having an entrapment efficiency of 65% to 85% were obtained. The effect of core to coat ratio, speed of agitation, temperature, and volume of oil phase was studied with respect to entrapment efficiency, micropellet size, and surface characteristics. Fourier transform infrared spectroscopy and differential scanning calorimetric analysis confirmed the absence of any drug-polymer interaction. X-ray diffraction patterns showed that there is a decrease in crystallinity of the drug. The micromeritic properties of micropellets were found to be slightly changed by changing various processing parameters to give micropellets of good flow property. The in vitro release profile could be altered significantly by changing various processing parameters to give a controlled release of drug from the micropellets. The stability studies of the drug-loaded micropellets showed that the drug was stable at storage conditions of room temperature, 37°C, 25°/60% relative humidity (RH) and 45°/60% RH, for 12 weeks.
ibuprofen; micropellets; gelatin micropellets
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