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1.  OR11-003 - The NLRP3 inflammasome is regulated by CaSR 
Pediatric Rheumatology Online Journal  2013;11(Suppl 1):A192.
doi:10.1186/1546-0096-11-S1-A192
PMCID: PMC3952243
2.  Preparation, characterization, and biodistribution study of technetium-99m-labeled leuprolide acetate-loaded liposomes in ehrlich ascites tumor-bearing mice 
AAPS PharmSci  2004;6(1):45-56.
The purpose of this study was to prepare conventional and sterically stabilized liposomes containing leuprolide acetate in an attempt to prolong the biological half life of the drug, to reduce the uptake by reticuloendothelial system (RES), and to reduce the injection frequency of intravenously administered peptide drugs. The conventional and sterically stabilized liposomes containing leuprolide acetate were prepared by reverse phase evaporation method and characterized for entrapment efficiency and particle size. Radiolabeling of leuprolide acetate and its liposomes was performed by direct labeling with reduced technetium-99m. Its biodistribution and imaging characteristics were studied in ehrlich ascites tumor (EAT)-bearing mice after labeling with technetium-99m. The systemic pharmacokinetic studies were performed in rabbits. A high uptake by tumor was observed by sterically stabilized liposome containing leuprolide acetate compared with free drug and conventional liposomes. The liver/tumor uptake ratio of free drug, conventional (LL), and sterically stabilized liposomes (SLL5000 and SLL2000) was found to be 20, 7.99, 1.63, and 1.23, respectively, which showed the increased accumulation of sterically stabilized liposomes in tumor compared with the free drug and conventional liposomes at 24 hours postinjection. Liver uptake of sterically stabilized liposomes was still 7-fold less than the conventional liposomes. The marked accumulation of liposomes in the tumor-bearing mice was also documented by gamma scintigraphic studies. The findings demonstrate the distribution of these liposomes within solid tumor and prove that the sterically stabilized liposomes experience increased tumor uptake and prolonged circulation half life. Hence these findings will be relevant for the optimal design of long circulating liposomes for the peptide drugs and for targeting of liposomes toward tumor.
doi:10.1208/ps060105
PMCID: PMC2750940  PMID: 15198506
sterically stabilized liposomes; leuprolide acetate; technetium-99m; biodistribution; gamma imaging
3.  SELF- ENUCLEATION OF EYES IN SCHIZOPHRENIA- AN UNUSUAL MODE OF DELIBERATE SELF HARM 
Indian Journal of Psychiatry  2001;43(4):351-353.
Self inflicted injury to the eyes including self-enucleation is a rare phenomenon. The authors describe a case of bilateral self-enucleation in a patient with paranoid schizophrenia. A review of literature shows that self-enucleation is correlated with moral, religious and psychodynamic paradigms and various unconscious mechanisms have been proposed to explain this unusual behaviour.
PMCID: PMC2956248  PMID: 21407887
Self-enucleation; deliberate self-harm; schizophrenia
4.  Treatment of typhoid. 
British Medical Journal  1973;1(5853):612.
PMCID: PMC1589883  PMID: 4571670

Results 1-4 (4)