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Allergy & Rhinology (1)
Journal of orthopaedic research : official publication of the Orthopaedic Research Society (1)
Wudel, Justin M. (2)
Anseth, Kristi S. (1)
Barham, Henry P. (1)
Chan, Kenny H. (1)
Enzenauer, Robert W. (1)
Genova, E. Erin (1)
Mariner, Peter D. (1)
Miller, David E. (1)
Streubel, Sven-Olrik (1)
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Synthetic hydrogel scaffold is an effective vehicle for delivery of INFUSE (rhBMP2) to critical-sized calvaria bone defects in rats
Mariner, Peter D.
Miller, David E.
Genova, E. Erin
Anseth, Kristi S.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Medtronic’s INFUSE Bone Graft provides surgeons with a potent tool for stimulating bone formation. Current delivery vehicles that rely on Absorbable Collagen Sponges (ACS) require excessive quantities of the active ingredient in INFUSE, recombinant human Bone Morphogenic Protein-2 (rhBMP2), to achieve physiologically relevant concentrations of the growth factor, driving up the cost of the product and increasing the likelihood of undesirable side effects in neighboring tissues. We demonstrate that a simple light-mediated, thiol-ene chemistry can be used to create an effective polymer delivery vehicle for rhBMP2, eliminating the use of xenografic materials and reducing the dose of rhBMP2 required to achieve therapeutic effects. Comprised entirely of synthetic components, this system entraps rhBMP2 within a biocompatible hydrogel scaffold that is degraded by naturally occurring remodeling enzymes, clearing the way for new tissue formation. When tested side-by-side with ACS in a critical-sized bone defect model in rats, this polymeric delivery system significantly increased bone formation over ACS controls.
INFUSE Bone Graft; recombinant human Bone Morphogenic Protein-2 (rhBMP2); Absorbable Collagen Sponge (ACS); delivery vehicle; hydrogel
Congenital nasolacrimal duct cyst/dacryocystocele: An argument for a genetic basis
Barham, Henry P.
Enzenauer, Robert W.
Chan, Kenny H.
Allergy & Rhinology
Embryogenesis of a congenital nasolacrimal duct (NLD) cyst is attributed to the failure of the Hasner membrane of the NLD system to cannulate. Prenatal diagnosis of congenital NLD cysts supports the argument for a developmental error, with a postnatal prevalence of 6%. The role of a genetic basis for this malformation has never been ascribed. We present a set of monozygotic twins with bilateral congenital NLD cysts as an argument for a genetic basis of this entity. A case report and literature review were performed. We present two cases of bilateral congenital NLD cysts occurring in a set of monozygotic twins. Patients were delivered at 37 weeks via cesarean section. The pregnancy was complicated by preterm labor at 33 weeks requiring administration of terbutaline and betamethasone. At presentation, twin A had bilateral eye discharge, erythema, and swelling medial to the medial canthi as well as nasal obstruction. Computed tomography (CT) showed classic bilateral cystic masses in the inferior meatus. The diagnosis of bilateral infected congenital dacryocystoceles was made. Twin B initially presented with only bilateral eye discharge and CT showed a dilated NLD system. Twin B subsequently developed early signs of bilateral dacryocystoceles the following day. Both patients underwent lacrimal probing and endoscopic marsupialization of the dacryocystoceles. Biopsies were consistent with dacryocystocele. Dacryocystocele is a common presentation of unresolved neonatal NLD obstruction. This case report in a set of identical twins is an argument for a genetic basis for the formation of this lesion.
Congenital; cyst; dacryocystocele; dacryocystorhinostomy; genetic; Hasner; nasolacrimal
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