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author:("audubon, Ozan")
1.  The Reason of Dissatisfaction of Patient after Septoplasty 
The Eurasian Journal of Medicine  2015;47(3):190-193.
The objective of this study was to evaluate the causes of persistent nasal obstruction of patients after septoplasty.
Materials and Methods:
After exclusion of allergic rhinitis, non-allergic rhinitis and nasal polyposis, this study included 90 patients with nasal breathing problem who underwent septoplasty at least 4 months ago. After taking full history and completing otorhinological and endoscopic examination, all patients graded their extent of obstruction using the Nasal Obstruction Symptoms Evaluation scale.
Our results showed only 45% of patients’ persist septal deviation; besides other obstructive pathologies, 55% were detected after detailed otolaryngologic evaluation.
Therefore, septal surgeons need to observe all obstructive causes of the nose carefully before planning the procedure.
PMCID: PMC4659521  PMID: 26644768
Nasal obstruction; septoplasty; endoscopic; rhinitis
2.  Early Skin Reaction of Polydioxanone Suture Material Following Septorhinoplasty 
Patient: Male, 27
Final Diagnosis: Postoperatif healing
Symptoms: Feeling of foreign body on the nasal tip
Medication: —
Clinical Procedure: Minor intervention and follow-ups
Specialty: Otolaryngology
Unusual clinical course
Septorhinoplasty is a frequent surgical procedure used for both cosmetic and functional purposes. The technique varies from surgeon to surgeon and according to which suture material is used. While some surgeons prefer non-absorbable sutures, others prefer sutures with delayed absorption. These materials sometimes protrude from the skin and they may cause skin reactions. While these reactions are common in the late period, a skin reaction in the early period because of polydioxanone suture is extremely rare and to the best of our knowledge, this is the first such reported case in the literature.
Case Report:
A 25-year-old male patient underwent endonasal septorhinoplasty procedure with endo-tracheal general anesthesia. We hereby present the skin reaction because of frequently used polydioxanone suture on the 24th postoperative day and the management of this patient. We cut the suture at skin level and prescribed antibiotherapy, and we scheduled a follow-up for 10 days afterwards. The patient had no complaint and the control examination result was normal.
When performing septorhinoplasty operations, very rare complications of the procedure shouldn’t be ignored and an informed consent must be obtained after explaining possible complications before the operation. This approach is important for increasing the patient compliance and proper follow-up for the patient. This way, especially post-operative early complications as our case will be able to be solved with close follow-up and intervention, before causing permanent damage. The relationship between patient who underwent rhinoplasty and the physician also has an important role on these follow-up visits.
PMCID: PMC4436945  PMID: 25951921
Polydioxanone; Postoperative Complications; Rhinoplasty
3.  Epidermal Inclusion Cyst of Thyroid Gland 
PMCID: PMC4341936  PMID: 25745353
4.  The Role of Thiamine Pyrophosphate in Prevention of Cisplatin Ototoxicity in an Animal Model 
The Scientific World Journal  2013;2013:182694.
Objective. The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods. Healthy guinea pigs (n = 18) were randomly divided into three groups. Group 1 (n = 6) received an intraperitoneal injection of saline solution and cisplatin for 7 days, group 2 (n = 6) received an intraperitoneal injection of thiamine pyrophosphate and cisplatin for 7 days, and group 3 (n = 6) received only intraperitoneal injection of saline for 7 days. The animals in all groups were sacrificed under anesthesia, and their cochleas were harvested for morphological and biochemical observations. Results. In group 1, receiving only cisplatin, cochlear glutathione concentrations, superoxide dismutase, and glutathione peroxidase activities significantly decreased (P < 0.05) and malondialdehyde concentrations significantly increased (P < 0.05) compared to the control group. In group 2, receiving thiamine pyrophosphate and cisplatin, the concentrations of enzymes were near those of the control group. Microscopic examination showed that outer hair cells, spiral ganglion cells, and stria vascularis were preserved in group 2. Conclusion. Systemic administration of thiamine pyrophosphate yielded statistically significant protection to the cochlea of guinea pigs from cisplatin toxicity. Further experimental animal studies are essential to determine the appropriate indications of thiamine pyrophosphate before clinical use.
PMCID: PMC3791633  PMID: 24163613
5.  Postoperative cephazolin usage is sufficient for preventing infection after septoplasty procedure 
Allergy & Rhinology  2011;2(2):e54-e57.
The use of antibiotics in septoplasty is a common practice among most ear, nose, and throat doctors; however, there are few studies proving the efficacy, which is considered as unnecessary by some authors. The aim of this pilot study was to evaluate the effect of two different kinds of antimicrobial agent on efficacy and safety after septoplasty surgery and to show that use of cephazolin, 1.0 g, postoperatively, might be sufficient for preventing infection after septoplasty procedure. Patients were randomly divided into two groups with a simple randomization method. The first group of 80 patients received cephazolin, 1.0 g i.v., once postoperatively and the second group of 80 patients received amoxicillin–clavulanate orally for 7 days postoperatively (1000 mg). An early and late postoperative questionnaire and nasal endoscopy evaluation was performed and patients were followed up in the outpatient service to investigate the presence of complications. There was no significant difference in postoperative pain between groups A and B, using visual analog scale scores at the 1st postoperative day. There were no differences related to the amount of purulent discharge found at the lower margin of the inferior turbinate through nasal endoscopy performed on the 14th day postoperatively. There were no statistical significances among groups for complications rates and postoperative endoscopic evaluation. Septoplasties are considered potentially contaminated surgeries, and cephazolin, 1.0 g i.v., given once postoperatively is enough to prevent potential complications with its easy and effective use.
PMCID: PMC3390117  PMID: 22852118
Amoxicillin; antibiotics; cephazolin; complication; postoperative; septoplasty

Results 1-5 (5)