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1.  Erratum 
PMCID: PMC3308646
2.  The NHS White Paper: licence for radical cultural reform of the NHS? 
PMCID: PMC3078606  PMID: 21502212
5.  Exposing the evidence gap for complementary and alternative medicine to be integrated into science-based medicine 
When people who advocate integrating conventional science-based medicine with complementary and alternative medicine (CAM) are confronted with the lack of evidence to support CAM they counter by calling for more research, diverting attention to the ‘package of care’ and its non-specific effects, and recommending unblinded ‘pragmatic trials’. We explain why these responses cannot close the evidence gap, and focus on the risk of biased results from open (unblinded) pragmatic trials. These are clinical trials which compare a treatment with ‘usual care’ or no additional care. Their risk of bias has been overlooked because the components of outcome measurements have not been taken into account. The components of an outcome measure are the specific effect of the intervention and non-specific effects such as true placebo effects, cognitive measurement biases, and other effects (which tend to cancel out when similar groups are compared). Negative true placebo effects (‘frustrebo effects’) in the comparison group, and cognitive measurement biases in the comparison group and the experimental group make the non-specific effect look like a benefit for the intervention group. However, the clinical importance of these effects is often dismissed or ignored without justification. The bottom line is that, for results from open pragmatic trials to be trusted, research is required to measure the clinical importance of true placebo effects, cognitive bias effects, and specific effects of treatments.
PMCID: PMC3078611  PMID: 21502214
6.  Mass extinction and the medical profession 
PMCID: PMC3078612  PMID: 21502210
7.  From JRSM Short Reports 
PMCID: PMC3078613
8.  An evolution of professionalism 
PMCID: PMC3078614  PMID: 21502209
9.  Extending medical professionalism 
PMCID: PMC3078615  PMID: 21502211
10.  Epilepsy is different 
PMCID: PMC3078616  PMID: 21502208
12.  Coronial autopsies 
PMCID: PMC3046189  PMID: 21357973
13.  Attracting, retaining and nurturing young academic clinicians 
PMCID: PMC3046190  PMID: 21357972
14.  The history and evolution of sutures in pelvic surgery 
The purpose of the study is to review the history and innovations of sutures used in pelvic surgery. Based on a review of the literature using electronic- and hand-searched databases we identified appropriate articles and gynaecology surgical textbooks regarding suture for wound closure. The first documented uses of suture are explored and then the article focuses on the use of knotted materials in pelvic surgery. The development of suture of natural materials is followed chronologically until the present time where synthetic suture is implanted during countless surgeries every day. This millennial history of suture contains an appreciation of the early work of Susruta, Celsus, Paré and Lister, including a survey of some significant developments of suture methods over the last 100 years. Most surgeons know little about the history and science of sutures. A retrospective view of suture is critical to the appreciation of the current work and development of this common tool.
PMCID: PMC3046193  PMID: 21357979
18.  Alcohol and cholera 
PMCID: PMC3046197  PMID: 21357976
20.  The discovery of thyroid replacement therapy. Part 3: A complete transformation 
PMCID: PMC3046199  PMID: 21357978
22.  From JRSM Short Reports 
PMCID: PMC3046201
23.  Michelin-starred theatres 
PMCID: PMC3046202  PMID: 21357974
24.  Information revolution – from healthcare to i-care 
PMCID: PMC3046203  PMID: 21357984
25.  The head chef 
PMCID: PMC3046204  PMID: 21357975

Results 1-25 (603)