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1.  Erratum 
Abbasi K. Science, a weapon of peace. J R Soc Med 2013; 106: 207. The name of the third author in the first reference was published incorrectly in the above Editorial. The correct author name should appear as Dubois E.
DOI: 10.1177/0141076814565070
doi:10.1177/0141076814565070
PMCID: PMC4291333
2.  Correction: Incorrect Spelling of Author's Name 
doi:10.1177/0141076814542900
PMCID: PMC4093765  PMID: 25013100
3.  Erratum 
Pei Chia Eng and Dworakowska Dorota. Persistent fever in a young woman. J R Soc Med February 2014 107: 75–78, first published on December 13, 2013 doi: 10.1177/0141076813512819
doi:10.1177/0141076814530612
PMCID: PMC4109343
5.  Sarcoidosis presenting as complete heart block in a 45-year-old farmer: an aetiology not to miss 
Sarcoidosis should always be part of the differential diagnosis when faced with a young patient with significant cardiac conduction disease.
doi:10.1177/0141076813503592
PMCID: PMC3883146  PMID: 24108537
6.  A case of ‘cardiology envy’? 
doi:10.1177/0141076813504396
PMCID: PMC3883147  PMID: 24108535
7.  Advances in motor neurone disease 
Summary
Motor neurone disease (MND), the commonest clinical presentation of which is amyotrophic lateral sclerosis (ALS), is regarded as the most devastating of adult-onset neurodegenerative disorders. The last decade has seen major improvements in patient care, but also rapid scientific advances, so that rational therapies based on key pathogenic mechanisms now seem plausible. ALS is strikingly heterogeneous in both its presentation, with an average one-year delay from first symptoms to diagnosis, and subsequent rate of clinical progression. Although half of patients succumb within 3–4 years of symptom onset, typically through respiratory failure, a significant minority survives into a second decade. Although an apparently sporadic disorder for most patients, without clear environmental triggers, recent genetic studies have identified disease-causing mutations in genes in several seemingly disparate functional pathways, so that motor neuron degeneration may need to be understood as a common final pathway with a number of upstream causes. This apparent aetiological and clinical heterogeneity suggests that therapeutic studies should include detailed biomarker profiling, and consider genetic as well as clinical stratification. The most common mutation, accounting for 10% of all Western hemisphere ALS, is a hexanucleotide repeat expansion in C9orf72. This and several other genes implicate altered RNA processing and protein degradation pathways in the core of ALS pathogenesis. A major gap remains in understanding how such fundamental processes appear to function without obvious deficit in the decades prior to symptom emergence, and the study of pre-symptomatic gene carriers is an important new initiative.
doi:10.1177/0141076813511451
PMCID: PMC3883149  PMID: 24399773
amyotrophic lateral sclerosis; frontotemporal dementia; neurodegeneration; anterior horn cell; RNA; TDP-43; autophagy; protein aggregation
9.  ‘Tesco’ NHS 
doi:10.1177/0141076813512247
PMCID: PMC3883151  PMID: 24399771
10.  The origins of vaccination: history is what you remember 
doi:10.1177/0141076813513998
PMCID: PMC3883152  PMID: 24399772
11.  The evolution of ways of deciding when clinical trials should stop recruiting 
doi:10.1177/0141076813514681
PMCID: PMC3883153  PMID: 24399774
12.  From JRSM Open 
doi:10.1177/0141076813516060
PMCID: PMC3883154
14.  Death Notices 
doi:10.1177/0141076813517453
PMCID: PMC3883156
15.  From populism to population healthcare 
doi:10.1177/0141076816682400
PMCID: PMC5154415  PMID: 27923891
16.  Depression and anxiety in Babylon 
doi:10.1177/0141076813486262
PMCID: PMC3842853  PMID: 23759889
17.  Return of the memento mori: Imaging death in public health 
doi:10.1177/0141076813495828
PMCID: PMC3842855  PMID: 24025227
18.  Kola nut: so much more than just a nut 
doi:10.1177/0141076813507708
PMCID: PMC3842857  PMID: 24158941
19.  Idealism includes compassion and commitment to patients 
doi:10.1177/0141076813509148
PMCID: PMC3842858  PMID: 24284995
21.  Junk food and heart disease: the missing tooth 
doi:10.1177/0141076813512297
PMCID: PMC3842860  PMID: 24284994
22.  Death Notices 
doi:10.1177/0141076813512582
PMCID: PMC3842861
23.  For more events and to book online, please visit www.rsm.ac.uk/diary 
doi:10.1177/0141076813512583
PMCID: PMC3842862
24.  From JRSM Short Reports 
doi:10.1177/0141076813512585
PMCID: PMC3842863
25.  Time for politicians to learn from clinicians 
doi:10.1177/0141076816677163
PMCID: PMC5117182

Results 1-25 (1032)