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1.  State of the Art of Mechanical Circulatory Support 
Texas Heart Institute Journal  2014;41(2):115-120.
Mechanical circulatory support of the failing heart has become an important means of treating end-stage heart disease. This rapidly growing therapeutic field has produced impressive clinical outcomes and has great potential to help thousands of otherwise terminal patients worldwide. In this review, we examine the state of the art of mechanical circulatory support: current practice, totally implantable systems of the future, evolving biventricular support mechanisms, the potential for myocardial recovery and adjunctive treatment methods, and miniaturized devices with expanded indications for therapy.
doi:10.14503/THIJ-14-4143
PMCID: PMC4004468  PMID: 24808767
Assisted circulation/instrumentation; device removal; equipment design; heart failure/therapy; heart-assist devices/trends/utilization; patient selection; recovery of function; treatment outcome; ventricular dysfunction, left/therapy; ventricular function/physiology
2.  Bileaflet versus Posterior-Leaflet-Only Preservation in Mitral Valve Replacement 
Texas Heart Institute Journal  2014;41(2):165-169.
In the present study of mitral valve replacement, we investigated whether complete preservation of both leaflets (that is, the subvalvular apparatus) is superior to preservation of the posterior leaflet alone.
Seventy patients who underwent mitral valve replacement in our clinic were divided into 2 groups: MVR-B (n=16), in whom both leaflets were preserved, and MVR-P (n=54), in whom only the posterior leaflet was preserved. The preoperative and postoperative clinical and echocardiographic findings were evaluated retrospectively.
No signs of left ventricular outflow tract obstruction were observed in either group. In the MVR-B group, no decrease was observed in left ventricular ejection fraction during the postoperative period, whereas a significant reduction was observed in the MVR-P group (P=0.003). No differences were found between the 2 groups in their need for inotropic agents or intra-aortic balloon pump support, or in cross-clamp time, duration of intensive care unit or hospital stays, postoperative development of new atrial fibrillation, or mortality rates.
Bileaflet preservation prevented the decrease in left ventricular ejection fraction that usually followed preservation of the posterior leaflet alone. However, posterior leaflet preservation alone yielded excellent results in terms of decreased left ventricular diameter. Bileaflet preservation should be the method of choice to prevent further decreases in ejection fraction and to avoid death in patients who present with substantially impaired left ventricular function.
doi:10.14503/THIJ-13-3164
PMCID: PMC4004467  PMID: 24808776
Chordae tendineae/surgery; heart valve prosthesis implantation; mitral valve/surgery; mitral valve insufficiency; mitral valve stenosis; papillary muscles/surgery; postoperative complications/prevention & control; retrospective studies; rheumatic heart disease; treatment outcome; ventricular function, left
3.  Large Lipomatous Hypertrophy of the Interventricular Septum 
Texas Heart Institute Journal  2014;41(2):231-233.
We present the case of a 58-year-old woman who had large lipomatous hypertrophy of the interventricular septum, a condition that is reported very infrequently. Preoperative cardiac magnetic resonance images revealed an inhomogeneous, infiltrating mass that was suppressed in fat-suppression mode. The extensive mass was causing right ventricular dysfunction, so we excised it through a right ventricular approach. The findings on histologic analysis of the mass were consistent with lipomatous hypertrophy. The patient died of septic shock on the 28th postoperative day. In addition to the patient's case, we discuss the characteristics and diagnosis of this rare entity.
doi:10.14503/THIJ-13-3336
PMCID: PMC4004469  PMID: 24808791
Adipose tissue/pathology; heart septum/pathology/surgery; hypertrophy/complications; lipomatosis/complications/diagnosis/surgery; ventricular septum/pathology
4.  Acute Coronary Thrombosis and Multiple Coronary Aneurysms in a 22-Year-Old Man with the Human Immunodeficiency Virus 
Texas Heart Institute Journal  2014;41(2):208-211.
The human immunodeficiency virus (HIV) can cause diverse cardiovascular complications. In HIV patients on antiretroviral therapy, the prevalence of myocardial infarction has steadily increased over the years. Young patients who are naïve to antiretroviral therapy and who experience coronary events are not well represented in the medical literature. We describe the case of a 22-year-old man, infected with HIV for 4 years and never treated with antiretroviral therapy, who emergently presented with a non-ST-segment-elevation myocardial infarction. Coronary angiograms revealed thrombosis and multiple coronary artery aneurysms; however, no areas of atherosclerotic stenosis were apparent. He was successfully treated with coronary stenting, antiplatelet therapy, and anticoagulation. Nine months after the initial presentation, he exhibited excellent exercise capacity, and no ischemia was evident. We discuss the various therapeutic approaches in this case.
doi:10.14503/THIJ-13-3160
PMCID: PMC4004470  PMID: 24808786
Anticholesteremic agents/therapeutic use; anticoagulants/therapeutic use; cardiovascular diseases/diagnosis/etiology/therapy; coronary aneurysm/diagnosis/drug therapy/epidemiology/etiology; HIV infections/complications; risk factors; treatment outcome; vasculitis/physiopathology/virology
5.  Takotsubo Cardiomyopathy as a Sequela of Elective Direct-Current Cardioversion for Atrial Fibrillation 
Texas Heart Institute Journal  2014;41(2):184-187.
In takotsubo cardiomyopathy, the clinical appearance is that of an acute myocardial infarction in the absence of obstructive coronary artery disease, with apical ballooning of the left ventricle. The condition is usually precipitated by a stressful physical or psychological experience. The mechanism is unknown but is thought to be related to catecholamine excess. We present the case of a 67-year-old woman who experienced cardiogenic shock caused by takotsubo cardiomyopathy, immediately after undergoing elective direct-current cardio-version for atrial fibrillation. After a course complicated by left ventricular failure, cardiogenic shock, and ventricular tachycardia, she made a complete clinical and echocardiographic recovery. In addition to this case, we discuss the possible direct effect of cardioversion in takotsubo cardiomyopathy.
doi:10.14503/THIJ-12-3063
PMCID: PMC4004471  PMID: 24808781
Cardiomyopathies/etiology; electric countershock/adverse effects; recovery of function/physiology; shock, cardiogenic/therapy; takotsubo cardiomyopathy/complications/diagnosis/etiology/physiopathology; treatment outcome; ventricular function, left/physiology
6.  Staged Balloon Aortic Valvuloplasty before Standard Aortic Valve Replacement in Selected Patients with Severe Aortic Valve Stenosis 
Texas Heart Institute Journal  2014;41(2):152-158.
This study evaluated preoperative balloon aortic valvuloplasty (BAV) as a technique to decrease aortic valve replacement (AVR) risk in patients who have severe symptomatic aortic valve stenosis with substantial comorbidity.
We report the outcomes of 18 high-risk patients who received BAV within 180 days before AVR from November 1993 through December 2011. Their median age was 78 years (range, 51–93 yr), and there were 11 men (61%). The pre-BAV median calculated Society of Thoracic Surgeons Predicted Risk of Mortality (STS PROM) was 18.3% (range, 9.4%–50.7%). Preoperative left ventricular ejection fraction measured a median of 0.23 (range, 0.05–0.68), and the median aortic valve area index was 0.4 cm2/m2 (range, 0.2–0.7 cm2/m2). The median interval from BAV to AVR was 28 days (range, 1–155 d). There were no strokes or deaths after BAV; however, 4 patients (22%) required mechanical circulatory support, 3 (17%) required femoral artery operation, and 1 (6%) developed severe aortic valve regurgitation. After BAV, the median STS PROM fell to 9.1% (range, 2.6%–25.7%) (compared with pre-BAV, P <0.001). Echocardiography before AVR showed that the median left ventricular ejection fraction had improved to 0.35 (range, 0.15–0.66), and the aortic valve area index to 0.5 cm2/m2 (range, 0.3–0.7 cm2/m2) (compared with pre-BAV, both P <0.05). All patients received AVR. Operative death occurred in 2 patients (11%), and combined operative death and morbidity in 7 patients (39%).
Staged BAV substantially reduces the operative risk associated with AVR in selected patients.
doi:10.14503/THIJ-13-3298
PMCID: PMC4004472  PMID: 24808774
Algorithms; aortic valve stenosis/surgery/therapy; balloon valvuloplasty, aortic; calcinosis/therapy; heart valve prosthesis implantation/mortality; retrospective studies; treatment outcome
8.  Right Ventricular Sarcoidosis: Is It Time for Updated Diagnostic Criteria? 
Texas Heart Institute Journal  2014;41(2):203-207.
A 55-year-old woman with a history of complete heart block, atrial flutter, and progressive right ventricular failure was referred to our tertiary care center to be evaluated for cardiac transplantation. The patient's clinical course included worsening right ventricular dysfunction for 3 years before the current evaluation. Our clinical findings raised concerns about arrhythmogenic right ventricular cardiomyopathy. Noninvasive imaging, including a positron emission tomographic scan, did not reveal obvious myocardial pathologic conditions. Given the end-stage nature of the patient's right ventricular failure and her dependence on inotropic agents, she underwent urgent listing and subsequent heart transplantation. Pathologic examination of the explanted heart revealed isolated right ventricular sarcoidosis with replacement fibrosis. Biopsy samples of the cardiac allograft 6 months after transplantation showed no recurrence of sarcoidosis. This atypical presentation of isolated cardiac sarcoidosis posed a considerable diagnostic challenge. In addition to discussing the patient's case, we review the relevant medical literature and discuss the need for updated differential diagnostic criteria for end-stage right ventricular failure that mimics arrhythmogenic right ventricular cardiomyopathy.
doi:10.14503/THIJ-12-3086
PMCID: PMC4004474  PMID: 24808785
Arrhythmogenic right ventricular dysplasia/diagnosis; cardiomyopathies/complications; diagnosis, differential; diagnostic techniques, cardiovascular; sarcoidosis/diagnosis/physiopathology; ventricular dysfunction, right/diagnosis/etiology/physiopathology
9.  Sacrifice of a Human Heart 
Texas Heart Institute Journal  2014;41(2):133-134.
doi:10.14503/THIJ-13-3755
PMCID: PMC4004475  PMID: 24808771
10.  ST-Elevation Myocardial Infarction and Myelodysplastic Syndrome with Acute Myeloid Leukemia Transformation 
Texas Heart Institute Journal  2014;41(2):234-237.
Acute myocardial infarction and acute myeloid leukemia are rarely reported as concomitant conditions. The management of ST-elevation myocardial infarction (STEMI) in patients who have acute myeloid leukemia is challenging: the leukemia-related thrombocytopenia, platelet dysfunction, and systemic coagulopathy increase the risk of bleeding, and the administration of thrombolytic agents can be fatal. We report the case of a 76-year-old man who presented emergently with STEMI, myelodysplastic syndrome, and newly recognized acute myeloid leukemia transformation. Standard antiplatelet and anticoagulation therapy were contraindicated by the patient's thrombocytopenia and by his reported ecchymosis and gingival bleeding upon admission. He declined cardiac catheterization, was provided palliative care, and died 2 hours after hospital admission.
We searched the English-language medical literature, found 8 relevant reports, and determined that the prognosis for patients with concomitant STEMI and acute myeloid leukemia is clearly worse than that for either individual condition. No guidelines exist to direct the management of STEMI and concomitant acute myeloid leukemia. In 2 reports, dual antiplatelet therapy, anticoagulation, and drug-eluting stent implantation were used without an increased risk of bleeding in the short term, even in the presence of thrombocytopenia. However, we think that a more conservative approach—balloon angioplasty with the provisional use of bare-metal stents—might be safer. Simultaneous chemotherapy for the acute myeloid leukemia is crucial. Older age seems to be a major risk factor: patients too frail for emergent treatment can die within hours or days.
doi:10.14503/THIJ-12-2905
PMCID: PMC4004476  PMID: 24808792
Angina, unstable/diagnosis/pathology; chest pain/etiology; combined modality therapy; coronary disease/blood; fatal outcome; leukemia, myeloid, acute/complications/therapy; myocardial infarction/complications/etiology; risk factors
11.  Sudden Cardiac Arrest at the Finish Line: In Coronary Ectopia, the Cause of Ischemia Is from Intramural Course, Not Ostial Location 
Texas Heart Institute Journal  2014;41(2):212-216.
A 26-year-old woman, a well-trained runner, had a sudden cardiac arrest just before crossing the finish line of a marathon. She was rapidly resuscitated and was later found to have an ectopic origin of the left coronary artery. This anomaly was surgically repaired by translocating the ostium from the right to the left sinus of Valsalva. Her difficult postoperative course prompted further coronary evaluation, which revealed severe stenosis of the neoostium. The patient underwent a second operation: this time, the stenosis was bypassed via a left internal mammary artery-to-left anterior descending coronary artery (LAD) graft. Hypoplasia of the LAD and spasm during manipulation caused the graft to fail, necessitating double-stent angioplasty of the left main ostium and the LAD 2 months later. At the patient's 6-month follow-up examination, she had no further evidence of functional ischemia, and she resumed jogging.
Because the mode and mechanism of the patient's condition and events were documented in unusual detail, this case furthers our understanding of sudden cardiac arrest in athletes who have rare coronary anomalies. We conclude that ectopia of a coronary artery does not itself cause potentially fatal ischemia. Rather, these events are due to the ectopic artery's intramural proximal course within the aortic media, which might result in critical stenosis by means of hypoplasia or lateral compression of the artery.
doi:10.14503/THIJ-12-2867
PMCID: PMC4004477  PMID: 24808787
Cardiac surgical procedures; coronary stenosis/etiology; coronary vessel anomalies/classification/complications/diagnosis/surgery; coronary vessels/ultrasonography; death, sudden, cardiac/etiology/pathology/prevention & control; sinus of Valsalva/abnormalities; treatment outcome; ultrasonography, interventional
13.  Telephonic Terrorism 
Texas Heart Institute Journal  2014;41(2):131-132.
doi:10.14503/THIJ-12-3024
PMCID: PMC4004479  PMID: 24808770
14.  Percutaneous Retrograde Transfemoral Closure of Mitral Paravalvular Leak in 3 Patients without Construction of an Arteriovenous Wire Loop 
Texas Heart Institute Journal  2014;41(2):170-173.
Percutaneous closure of paravalvular leaks has emerged as an alternative to repeated surgeries. Different percutaneous techniques and various devices have been used, off-label, for paravalvular leak closure. For mitral leaks, antegrade transseptal, retrograde transfemoral, and retrograde transapical techniques have been developed. In the antegrade transseptal approach, an arteriovenous guidewire loop is often created to advance the delivery sheath. In retrograde transfemoral closure, the wire in the left atrium is usually snared after transseptal puncture, to pull it from the femoral vein. The delivery sheath and closure device will subsequently be deployed from the left atrium. Each of these procedures takes time, is costly, and increases the risk of complications.
We present the cases of 3 patients in whom we closed mitral paravalvular leaks by means of a retrograde transfemoral approach, with use of an Amplatzer™ Duct Occluder II device and without the construction of an arteriovenous wire loop. We think that this approach can be very useful in a specific group of patients—reducing costs, fluoroscopy times, and complications related to transseptal puncture and construction of an arteriovenous wire loop. In our institution, this reported technique is routinely used for mitral paravalvular leak closure.
doi:10.14503/THIJ-12-3017
PMCID: PMC4004480  PMID: 24808777
Cardiac catheterization/instrumentation; heart valve prosthesis implantation/instrumentation/methods; mitral valve/pathology; mitral valve insufficiency/etiology/therapy; prosthesis implantation/adverse effects/methods; septal occluder device; treatment outcome
16.  In Memoriam: Mavis P. Kelsey, Sr. (1912–2013) 
Texas Heart Institute Journal  2014;41(2):121-122.
doi:10.14503/THIJ-14-4232
PMCID: PMC4004482  PMID: 24919213
17.  Use of a Sandwich Technique to Repair a Left Ventricular Rupture after Mitral Valve Replacement 
Texas Heart Institute Journal  2014;41(2):195-197.
One difficulty with external repair of left ventricular rupture after mitral valve replacement is collateral bleeding in friable myocardium adjacent to the rupture. The bleeding is caused by tension on the closing sutures, whether or not pledgets have been used.
We report the case of a 69-year-old woman who underwent an uneventful mitral valve replacement. After cardiopulmonary bypass was terminated, brisk bleeding started from high in the posterior left ventricular wall, typical of a type III defect. We undertook external repair, placing a plug of Teflon felt into the cavity of the rupture and sandwiching it into place with pledgeted mattress and figure-of-8 sutures. The space occupied by the plug decreased the distance needed to obliterate the defect and thereby reduced the tension on the sutures necessary to achieve hemostasis. This simple technique enabled closure of the defect and avoided collateral tears that would have compromised an otherwise successful repair. Two years postoperatively, the patient had normal mitral valve function and no left ventricular aneurysm. In addition to reporting the patient's case, we review the types of left ventricular rupture that can occur during mitral valve replacement and discuss the various repair options.
doi:10.14503/THIJ-12-2931
PMCID: PMC4004483  PMID: 24808783
Cardiac surgical procedures/adverse effects; heart rupture/etiology; heart valve prosthesis implantation/adverse effects; heart ventricles/injuries/surgery; mitral valve insufficiency/surgery; surgical techniques; treatment outcome
18.  Is It Ever Wise to Disregard Absolute Practice Guidelines? Absolutely 
Texas Heart Institute Journal  2014;41(2):177-178.
doi:10.14503/THIJ-13-3971
PMCID: PMC4004484  PMID: 24808779
20.  Novel Treatment of an Infiltrating Cardiac Fibrosarcoma 
Texas Heart Institute Journal  2014;41(2):248-249.
doi:10.14503/THIJ-13-3402
PMCID: PMC4004486  PMID: 24808797
21.  Infective Endocarditis Caused by Neisseria elongata on a Native Tricuspid Valve and Confirmed by DNA Sequencing 
Texas Heart Institute Journal  2014;41(2):227-230.
Neisseria elongata, a common oral bacterium, has been recognized as a cause of infections such as infective endocarditis, septicemia, and osteomyelitis. Neisseria-induced infective endocarditis, although infrequently reported, typically arises after dental procedures. Without antibiotic therapy, its complications can be severe.
We report the case of a 27-year-old man who presented with fever, severe dyspnea, and a leg abscess from cellulitis. An echocardiogram showed a vegetation-like echogenic structure on the septal leaflet of the patient's native tricuspid valve, and an insignificant Gerbode defect. Three blood cultures grew gram-negative, antibiotic-susceptible coccobacilli that were confirmed to be N. elongata. Subsequent DNA sequencing conclusively isolated N. elongata subsp nitroreducens as the organism responsible for the infective endocarditis. The patient recovered after 21 days of antibiotic therapy. In addition to the patient's unusual case, we discuss the nature and isolation of N. elongata and its subspecies.
doi:10.14503/THIJ-13-3153
PMCID: PMC4004487  PMID: 24808790
Bacterial typing techniques; DNA, bacterial/analysis; endocarditis, bacterial/complications/drug therapy/microbiology; gram-negative bacterial infections/diagnosis/drug therapy; heart valve diseases/diagnosis/drug therapy; heart ventricles/abnormalities; Neisseria elongata/analysis/classification/isolation & purification/microbiology/pathogenicity; species specificity; treatment outcome
22.  Microvascular Permeability Changes Might Explain Cardiac Tamponade after Alcohol Septal Ablation for Hypertrophic Cardiomyopathy 
Texas Heart Institute Journal  2014;41(2):217-221.
Various sequelae of alcohol septal ablation for hypertrophic obstructive cardiomyopathy have been reported. Of note, some cases of cardiac tamponade after alcohol septal ablation cannot be well explained. We describe the case of a 78-year-old woman with hypertrophic obstructive cardiomyopathy in whom cardiac tamponade developed one hour after alcohol septal ablation, probably unrelated to mechanical trauma. At that time, we noted a substantial difference in the red blood cell-to-white blood cell ratio between the pericardial effusion (1,957.4) and the peripheral blood (728.3). In addition to presenting the patient's case, we speculate that a possible mechanism for acute tamponade—alcohol-induced changes in microvascular permeability—is a reasonable explanation for cases of alcohol septal ablation that are complicated by otherwise-unexplainable massive pericardial effusions.
doi:10.14503/THIJ-12-3118
PMCID: PMC4004488  PMID: 24808788
Cardiac tamponade/etiology; cardiomyopathy, hypertrophic/complications/physiopathology/therapy; catheter ablation/adverse effects; ethanol/administration & dosage/adverse effects/therapeutic use; ventricular outflow obstruction/etiology
23.  Serum Levels of Soluble ICAM-1 in Children with Pulmonary Artery Hypertension 
Texas Heart Institute Journal  2014;41(2):159-164.
This prospective cross-sectional study attempted to determine both the usefulness of the serum intercellular adhesion molecule-1 (ICAM-1) as a biomarker for pulmonary artery hypertension secondary to congenital heart disease and the nature of this marker's association with catheter angiographic findings.
Our study included a total of 70 male and female children, comprising 30 patients with both pulmonary artery hypertension and congenital heart disease, 20 patients with congenital heart disease alone, and 20 healthy control subjects. Levels of ICAM-1 in plasma samples from all groups were measured by the enzyme-linked immunosorbent assay method. Cardiac catheterization was also performed in all patients.
The mean serum ICAM-1 levels in pediatric patients who had congenital heart disease with and without pulmonary artery hypertension were 349.6 ± 72.9 ng/mL and 312.3 ± 69.5 ng/mL, respectively (P=0.002). In healthy control subjects, the mean serum ICAM-1 level was 231.4 ± 60.4 ng/mL.
According to the results of this study, the ICAM-1 level of the pulmonary artery hypertension group was significantly higher than those of the congenital heart disease group and the healthy control group. Correlation analysis showed that ICAM-1 level was correlated with systolic and mean pulmonary artery pressures (r=0.62, P=0.001; r=0.57, P=0.001)—which are 2 important values used in diagnosis of pulmonary artery hypertension. Moreover, receiver operating characteristic analysis yielded consistent results for the prediction of pulmonary artery hypertension. Therefore, we conclude that ICAM-1 has potential use as a biomarker for the diagnosis and follow-up of pulmonary artery hypertension.
doi:10.14503/THIJ-12-3012
PMCID: PMC4004489  PMID: 24808775
Biological markers, blood; hypertension, pulmonary/blood/diagnosis/etiology; intercellular adhesion molecule-1/blood; prospective studies, cross-sectional
24.  Perioperative Outcomes after On- and Off-Pump Coronary Artery Bypass Grafting 
Texas Heart Institute Journal  2014;41(2):144-151.
Although numerous reports describe the results of off-pump coronary artery bypass grafting (CABG) at specialized centers and in select patient populations, it remains unclear how off-pump CABG affects real-world patient outcomes. We conducted a large, multicenter observational cohort study of perioperative death and morbidity in on-pump (ON) versus off-pump (OFF) CABG.
We reviewed Veterans Affairs Surgical Quality Improvement Program data for all patients (N=65,097) who underwent isolated CABG from October 1997 through April 2011 (intention-to-treat data were available from 2005 onward). The primary outcome was perioperative (30-day or in-hospital) death; the secondary outcomes were perioperative stroke, dialysis dependence, reoperation for bleeding, mechanical circulatory support, myocardial infarction, ventilator support ≥48 hr, and mediastinitis. Propensity scores calculated from age, 17 preoperative risk factors, and year of surgery were used to match 8,911 OFF with 26,733 ON patients.
In the complete cohort, compared with the ON patients (n=53,468), the OFF patients (n=11,629) had less perioperative death (2.02% vs 2.53%, P=0.0012) and lower incidences of all morbidities except perioperative myocardial infarction. In the matched cohort, perioperative death did not differ significantly between OFF and ON patients (1.94% vs 2.28%, P=0.06), but the OFF group had lower incidences of all morbidities except for perioperative myocardial infarction and mediastinitis. A subgroup intention-to-treat analysis yielded similar but smaller outcome differences between the ON and OFF groups.
Off-pump CABG might be associated with decreased operative morbidity but did not affect operative death, compared with on-pump CABG. Future studies should examine the effect of off-pump CABG on long-term outcomes.
doi:10.14503/THIJ-13-3372
PMCID: PMC4004490  PMID: 24808773
Cardiac surgical procedures/adverse effects/methods/mortality; coronary artery bypass/adverse effects/methods/mortality; morbidity; mortality; outcome assessment
25.  The Odyssey of TAVR from Concept to Clinical Reality 
Texas Heart Institute Journal  2014;41(2):125-130.
doi:10.14503/THIJ-14-4137
PMCID: PMC4004491  PMID: 24808769
Aortic stenosis; transcatheter valve implantation; valve prosthesis

Results 1-25 (883)