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1.  Computer-aided detection of brain tumor invasion using multiparametric MRI 
To determine the potential of using a computer-aided detection method to intelligently distinguish peritumoral edema alone from peritumor edema consisting of tumor using a combination of high-resolution morphological and physiological magnetic resonance imaging (MRI) techniques available on most clinical MRI scanners.
Materials and Methods
This retrospective study consisted of patients with two types of primary brain tumors: meningiomas (n=7) and glioblastomas (n=11). Meningiomas are typically benign and have a clear delineation of tumor and edema. Glioblastomas are known to invade outside the contrast-enhancing area. Four classifiers of differing designs were trained using morphological, diffusion-weighted, and perfusion-weighted features derived from MRI to discriminate tumor and edema, tested on edematous regions surrounding tumors, and assessed for their ability to detect nonenhancing tumor invasion.
The four classifiers provided similar measures of accuracy when applied to the training and testing data. Each classifier was able to identify areas of non-enhancing tumor invasion supported with adjunct images or follow-up studies.
The combination of features derived from morphological and physiological imaging techniques contains the information necessary for computer-aided detection of tumor invasion and allows for the identification of tumor invasion not previously visualized on morphological, diffusion-weighted, and perfusion-weighted images and maps. Further validation of this approach requires obtaining spatially co-registered tissue samples in a study with a larger sample size.
PMCID: PMC4321878  PMID: 19711398
MRI; computer-aided detection (CAD); brain tumor; perfusion; diffusion
2.  Quantification of Aortic Stiffness Using MR Elastography and its Comparison to MRI-Based Pulse Wave Velocity 
To determine the correlation in abdominal aortic stiffness obtained using magnetic resonance elastography (MRE) (μMRE) and MRI-based pulse wave velocity (PWV) shear stiffness (μPWV) estimates in normal volunteers of varying age; and also to determine the correlation between μMRE and μPWV.
In-vivo aortic MRE and MRI were performed on 21 healthy volunteers with ages ranging from 18 to 65 years to obtain wave and velocity data along the long-axis of the abdominal aorta. The MRE wave images were analyzed to obtain mean stiffness, and the phase contrast images were analyzed to obtain PWV measurements and indirectly estimate stiffness values from Moens-Korteweg equation.
Both μMRE and μPWV measurements increased with age, demonstrating linear correlations with R2 values of 0.81 and 0.67, respectively. Significant difference (p≤0.001) in mean μMRE and μPWV between young and old healthy volunteers was also observed. Furthermore, a poor linear correlation of R2 value of 0.43 was determined between μMRE and μPWV in initial pool of volunteers.
The results of this study indicate linear correlations between μMRE and μPWV with normal aging of the abdominal aorta. Significant differences in mean μMRE and μPWV between young and old healthy volunteers were observed.
PMCID: PMC4318508  PMID: 24243654
Aortic Stiffness; Magnetic Resonance Elastography (MRE); PWV; aortic MRE
3.  Changes in MR Relaxation Times of the Meniscus With Acute Loading: An In Vivo Pilot Study in Knee Osteoarthritis 
To prospectively evaluate changes in T1ρ and T2 relaxation times in the meniscal body with acute loading using MRI in osteoarthritic knees and to compare these findings with those of age-matched healthy controls.
Materials and Methods
Female subjects above 40 years of age with (N1 = 20) and without osteoarthritis (OA) (N2 = 10) were imaged on a 3 Tesla MR scanner using a custom made loading device. MR images were acquired, with the knee flexed at 20°, with and without a compressive load of 50% of the subject's bodyweight. The subjects were categorized based on the radiographic evidence of OA. Three different zones (outer, middle, and inner) of meniscus body were defined (each occupying 1/3rd the width). After adjusting for age and body mass index in the general linear regression model, repeated measures analysis of variance was used to detect significant differences in T1ρ and T2 with and without loading.
In the unloaded condition, the average T1ρ and T2 times were elevated in the outer and middle zones of the medial meniscus in OA subjects compared with the controls. In the loaded condition, T1ρ and T2 times of the outer zone of the medial meniscus was significantly elevated in OA subjects compared with controls. Finally the change (from unloaded to loaded) was significantly higher in controls than OA subjects (15.1% versus 8.3%; P = 0.039 for ΔT1ρ, and 11.5% versus 6.9%, P = 0.049 for ΔT2).
These findings suggest that while the OA process appears to affect the relaxation times of all regions within the meniscus, it may affect some regions sooner or to a greater degree. Furthermore, the differences in the change in relaxation times between unloaded and loaded conditions may reveal evidence about load transmission failure of the outer zone of the medial meniscus in subjects with knee OA. It is possible that these metrics (ΔT1ρ and ΔT2) may be valuable as an early biomechanical biomarker, which could be used to predict load transmission to the underlying articular cartilage.
PMCID: PMC4062611  PMID: 24347310
meniscus; acute loading; MR relaxation times; T1ρ and T2; osteoarthritis
4.  Automatic Iceball Segmentation With Adapted Shape Priors for MRI-Guided Cryoablation 
To develop and evaluate an automatic segmentation method that extracts the 3D configuration of the ablation zone, the iceball, from images acquired during the freezing phase of MRI-guided cryoablation.
Materials and Methods
Intraprocedural images at 63 timepoints from 13 kidney tumor cryoablation procedures were examined retrospectively. The images were obtained using a 3 Tesla wide-bore MRI scanner and axial HASTE sequence. Initialized with semiautomatically localized cryoprobes, the iceball was segmented automatically at each timepoint using the graph cut (GC) technique with adapted shape priors.
The average Dice Similarity Coefficients (DSC), compared with manual segmentations, were 0.88, 0.92, 0.92, 0.93, and 0.93 at 3, 6, 9, 12, and 15 min time-points, respectively, and the average DSC of the total 63 segmentations was 0.92 ± 0.03. The proposed method improved the accuracy significantly compared with the approach without shape prior adaptation (P = 0.026). The number of probes involved in the procedure had no apparent influence on the segmentation results using our technique. The average computation time was 20 s, which was compatible with an intraprocedural setting.
Our automatic iceball segmentation method demonstrated high accuracy and robustness for practical use in monitoring the progress of MRI-guided cryoablation.
PMCID: PMC4128910  PMID: 24338961
automatic iceball segmentation; graph cut; adapted shape prior; MRI-guided cryoablation
5.  [No title available] 
PMCID: PMC3735681  PMID: 23633229
6.  [No title available] 
PMCID: PMC3732566  PMID: 23596052
7.  [No title available] 
PMCID: PMC3732806  PMID: 23625854
8.  [No title available] 
PMCID: PMC3735670  PMID: 23633160
9.  [No title available] 
PMCID: PMC3735677  PMID: 23596017
10.  [No title available] 
PMCID: PMC3735857  PMID: 23596090
11.  [No title available] 
PMCID: PMC3751999  PMID: 23633244
12.  [No title available] 
PMCID: PMC3758375  PMID: 23681559
13.  [No title available] 
PMCID: PMC3761000  PMID: 23720394
14.  [No title available] 
PMCID: PMC3766421  PMID: 23733582
15.  [No title available] 
PMCID: PMC3766427  PMID: 23681649
16.  [No title available] 
PMCID: PMC3775904  PMID: 23589355
17.  Quantification of Liver Iron with MRI: State of the Art and Remaining Challenges 
Liver iron overload is the histological hallmark of hereditary hemochromatosis and transfusional hemosiderosis, and can also occur in chronic hepatopathies. Iron overload can result in liver damage, with the eventual development of cirrhosis, liver failure and hepatocellular carcinoma. Assessment of liver iron levels is necessary for detection and quantitative staging of iron overload, and monitoring of iron-reducing treatments. This article discusses the need for non-invasive assessment of liver iron, and reviews qualitative and quantitative methods with a particular emphasis on MRI. Specific MRI methods for liver iron quantification include signal intensity ratio as well as R2 and R2* relaxometry techniques. Methods that are in clinical use, as well as their limitations, are described. Remaining challenges, unsolved problems, and emerging techniques to provide improved characterization of liver iron deposition are discussed.
PMCID: PMC4308740  PMID: 24585403
Liver iron; MR relaxometry; R2; R2*; susceptometry
18.  Amide Proton Transfer MR Imaging of Prostate Cancer: A Preliminary Study 
To evaluate the capability of amide proton transfer (APT) MR imaging for detection of prostate cancer that typically shows a higher tumor cell proliferation rate and cellular density leading to an MRI-detectable overall elevated mobile protein level in higher grade tumors.
Materials and Methods
Twelve patients with biopsy-proven prostate cancer were imaged on a 3 Tesla MR imaging system before prostatectomy. APT-MR images were acquired by means of a single-slice single-shot turbo spin echo sequence with a saturation prepulse preparation using 33 different frequency offsets (−8 to 8 ppm, interval 0.5 ppm). For quantification we used the APT ratio (APTR) based on the asymmetry of the magnetization transfer ratio at 3.5 ppm in respect to the water signal. Tumor and peripheral zone benign regions of interest (ROIs) were delineated based on whole mount pathology slides after prostatectomy.
APTR in prostate cancer ROIs was 5.8% 6 3.2%, significantly higher than that in the peripheral zone benign regions (0.3% ± 3.2%, P = 0.002).
APT-MR imaging is feasible in prostate cancer detection and has the potential to discriminate between cancer and noncancer tissues.
PMCID: PMC4287206  PMID: 21563248
amide proton transfer; chemical exchange saturation transfer; prostate cancer; mobile protein level; molecular imaging
19.  Regional covariance patterns of gray matter alterations in Alzheimer’s disease and its replicability evaluation 
Journal of magnetic resonance imaging : JMRI  2013;39(1):10.1002/jmri.24143.
To identify regional network covariance patterns of gray matter associated with Alzheimer’s disease (AD) and to further evaluate its replicability and stability.
Materials and Methods
This study applied a multivariate analytic approach based on scaled subprofile modeling (SSM) to structural MRI data from 19 patients with AD and 19 healthy controls (HC). We further applied the derived covariance patterns to examine the replicability and stability of AD-associated covariance patterns in an independent dataset [13 AD and 14 HC] acquired with a different scanner.
The AD-associated covariance patterns identified from SSM combined principal components mainly involved the temporal lobe and parietal lobe. The expression of covariance patterns was significantly higher in AD patients than HC (t(36) = 5.84, p= 5.75E–7) and predicted the AD/HC group membership (84% sensitivity and 90% specificity). In replicability evaluation, the expression of the forward applied covariance patterns was still statistically significant and had acceptable discriminability (69% sensitivity and 71% specificity).
AD patients showed regional gray matter alterations in a reliable covariance manner. The results suggest that SSM has utility for characterizing covariant features, therefore, can assist us with further understanding covariance patterns of gray matter in AD based on the view of the network.
PMCID: PMC3732807  PMID: 23589138
multivariate analysis; scaled subprofile model; Alzheimer’s disease; structural MRI; voxel-based morphometry
20.  Compressed Sensing Reconstruction for Undersampled Breath-Hold Radial Cine Imaging with Auxiliary Free-Breathing Data 
Journal of magnetic resonance imaging : JMRI  2013;39(1):10.1002/jmri.24098.
To improve compressed sensing reconstruction of accelerated breath-hold (BH) radial cine MRI by exploiting auxiliary data acquired between different BHs.
Materials and Methods
Cardiac function is usually assessed using segmented cine acquisitions over multiple BHs to cover the entire left ventricle (LV). Subjects are given a resting period between adjacent BHs, when conventionally no data is acquired and subjects rest in the scanner. In this study, the resting periods between BHs are utilized to acquire additional free-breathing (FB) data, which are subsequently used to generate a sparsity constraint for each cardiac phase. Images reconstructed using the proposed sparsity constraint were compared with conventional compressed sensing (CS) using a composite image generated by averaging different cardiac phases. The efficacy of the proposed reconstruction is compared using indices of LV function and blood-myocardium sharpness.
The proposed method provides accurate LV ejection fraction measurements for 33% and 20% sampled data sets compared with fully-sampled reference images, and shows 14% and 11% higher blood-myocardium border sharpness scores compared to the conventional CS.
The FB data acquired during rest periods can be efficiently used to improve the image quality of the undersampled BH data without increasing the total scan time.
PMCID: PMC3800245  PMID: 23857797
compressed sensing; accelerated acquisition; radial acquisition; cardiac MR; cine imaging; breath-hold acquisition
21.  White Matter Lesion Load Is Associated With Resting State Functional MRI Activity and Amyloid PET but not FDG in Mild Cognitive Impairment and Early Alzheimer's Disease Patients 
To quantify and investigate the interactions between multimodal MRI/positron emission tomography (PET) imaging metrics in elderly patients with early Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy controls.
Materials and Methods
Thirteen early AD, 17 MCI patients, and 14 age-matched healthy aging controls from the Alzheimer's Disease Neuroimaging Initiative database were selected based on availability of data. Default mode network (DMN) functional connectivity and fractional amplitude of low frequency fluctuation (fALFF) were obtained for resting state functional MRI (RS-fMRI). White matter lesion load (WMLL) was quantified from MRI T2-weighted FLAIR images. Amyloid deposition with PET [18F]-Florbetapir tracer and metabolism of glucose by means of [18F]-fluoro-2-deoxyglucose (FDG) images were quantified using ratio of standard uptake values (rSUV).
Whole-brain WMLL and amyloid deposition were significantly higher (P < 0.005) in MCI and AD patients compared with controls. RS-fMRI results showed significantly reduced (corrected P < 0.05) DMN connectiv ity and altered fALFF activity in both MCI and AD groups. FDG uptake results showed hypometabolism in AD and MCI patients compared with controls. Correlations (P < 0.05) were found between WMLL and amyloid load, FDG uptake and amyloid load, as well as between amyloid load (rSUV) and fALFF.
Our quantitative results of four MRI and PET imaging metrics (fALFF/DMN, WMLL, amyloid, and FDG rSUV values) agree with published values. Signifi-cant correlations between MRI metrics, including WMLL/ functional activity and PET amyloid load suggest the potential of MRI and PET-based biomarkers for early detection of AD.
PMCID: PMC4097981  PMID: 24382798
white matter lesion; amyloid; resting state-fMRI; Alzheimer disease; fractional amplitude at low frequency fluctuation; default mode network
22.  Impact of Reduced k-Space Acquisition on Pathologic Detectability for Volumetric MR Spectroscopic Imaging 
Journal of magnetic resonance imaging : JMRI  2013;39(1):10.1002/jmri.24130.
To assess the impact of accelerated acquisitions on the spectral quality of volumetric MR spectroscopic imaging (MRSI) and to evaluate their ability in detecting metabolic changes with mild injury.
Materials and Methods
The implementation of a generalized autocalibrating partially parallel acquisition (GRAPPA) method for a high-resolution whole-brain echo planar SI (EPSI) sequence is first described and the spectral accuracy of the GRAPPA-EPSI method is investigated using lobar and voxel-based analyses for normal subjects and patients with mild traumatic brain injuries (mTBI). The performance of GRAPPA was compared with that of fully-encoded EPSI for 5 datasets collected from normal subjects at the same scanning session, as well as on 45 scans (20 normal subjects and 25 mTBI patients) for which the reduced k-space sampling was simulated. For comparison, a central k-space lower-resolution 3D-EPSI acquisition was also simulated. Differences in individual metabolites and metabolite ratio distributions of the mTBI group relative to those of age-matched control subjects were statistically evaluated using analyses divided into hemispheric brain lobes and tissue types.
GRAPPA-EPSI with 16-min scan time yielded robust and similar results in terms of MRSI quantitation, spectral fitting, and accuracy with that of fully sampled 3D-EPSI acquisitions and was more accurate than central k-space acquisition. Primary findings included high correlations (accuracy of 92.6%) between the GRAPPA and fully sampled results.
Although the reduced encoding method is associated with lower SNR that impact the quality of spectral analysis the use of parallel imaging method can lead to same diagnostic outcomes as of the fully sampled data when using the sensitivity-limited volumetric MRSI.
PMCID: PMC3706563  PMID: 23559504
MR spectroscopic imaging; parallel Imaging; traumatic brain injury; undersampled acquisition; clinical equivalency
23.  Clinical Evaluation of CAIPIRINHA: Comparison Against a GRAPPA Standard 
Journal of magnetic resonance imaging : JMRI  2013;39(1):10.1002/jmri.24105.
To evaluate image quality when using a CAIPIRINHA sampling pattern in comparison to a standard GRAPPA sampling pattern in patients undergoing a routine 3D breath-held liver exam. CAIPIRINHA uses an optimized phase encoding sampling strategy to alter aliasing artifacts in 3D acquisitions to improve parallel imaging reconstruction.
Twenty patient volunteers were scanned using a 3D VIBE acquisition with an acceleration factor of four using a CAIPIRINHA and standard GRAPPA sampling pattern. CAIPIRINHA and GRAPPA images were evaluated by three radiologists in a two alternative forced choice test, and the Wilcoxon signed rank test was performed.
The CAIPIRINHA sampling pattern was preferred in an average of 68% of the comparisons, and the Wilcoxon signed rank test showed a significant improvement in CAIPIRINHA images (p=0.014). This analysis indicates that in the given sample set, CAIPIRINHA preference over the GRAPPA standard was statistically significant.
This work shows that for an acceleration factor of four, a CAIPIRINHA accelerated VIBE acquisition provides significantly improved image quality in comparison to the current GRAPPA standard. This allows a further reduction in imaging time for similar spatial resolutions, which can reduce long breath-hold requirements in abdominal imaging, and may be particularly helpful in patients who cannot provide requisite breath-holds with current protocols.
PMCID: PMC3865024  PMID: 24123420
CAIPIRINHA; Body Imaging; Parallel Imaging; GRAPPA; Sampling Strategy
24.  3D Hemodynamics in Intracranial Aneurysms: Influence of Size and Morphology 
Journal of magnetic resonance imaging : JMRI  2013;39(1):10.1002/jmri.24110.
To employ 4D-flow MRI for the comprehensive in-vivo analysis of hemodynamics and its relationship to size and morphology of different intracranial aneurysms (IA). We hypothesize that different IA groups, defined by size and morphology, exhibit different velocity fields, wall shear stress and vorticity.
Materials and Methods
4D-flow MRI (spatial resolution=0.99–1.8×0.78–1.46×1.2–1.4mm3, temporal resolution=44–48ms) was performed in 19 IAs (18 patients, age=55.4 ± 13.8 years) with saccular (n=16) and fusiform (n=3) morphology and different sizes ranging from small (n=8, largest dimension=6.2 ± 0.4mm) to large and giant (n=11, 25 ± 7mm). Analysis included quantification of volumetric spatial-temporal velocity distribution, vorticity, and wall shear stress (WSS) along the aneurysms 3D surface.
4D-flow MRI revealed distinct hemodynamic patterns for large/giant saccular aneurysms (Group 1), small saccular aneurysms (Group 2) and large/giant fusiform aneurysms (Group 3). Saccular IA (Groups 1, 2) demonstrated significantly higher peak velocities (p<0.002) and WSS (p<0.001) compared to fusiform aneurysms. Although intra-aneurysmal 3D velocity distributions were similar for Group 1 and 2, vorticity and WSS was significantly (p<0.001) different (increased in Group 1 by 54%) indicating a relationship between IA size and hemodynamics. Group 3 showed reduced velocities (p<0.001) and WSS (p<0.001).
4D flow MRI demonstrated the influence of lesion size and morphology on aneurysm hemodynamics suggesting the potential of 4D-flow MRI to assist in the classification of individual aneurysms.
PMCID: PMC3865211  PMID: 24151067
intracranial aneurysms; 4D flow MRI; hemodynamics; WSS; vorticity; velocity
25.  Potential of Computer-aided Diagnosis of High Spectral and Spatial (HiSS) MRI in the Classification of Breast Lesions 
To compare the performance of CADx analysis of pre-contrast HiSS MRI to that of clinical DCE-MRI in the diagnostic classification of breast lesions.
Materials and Methods:
Thirty-four malignant and seven benign lesions were scanned using 2D HiSS and clinical 4D DCE-MRI protocols. Lesions were automatically segmented. Morphological features were calculated for HiSS whereas both morphological and kinetic features were calculated for DCE-MRI. After stepwise feature selection, Bayesian artificial neural networks merged selected features, and ROC analysis evaluated the performance with leave-one-lesion-out validation.
AUC values of 0.92 ± 0.06 and 0.90 ± 0.05 were obtained using CADx on HiSS and DCE-MRI, respectively, in the task of classifying benign and malignant lesions. While we failed to show that the higher HiSS performance was significantly better than DCE-MRI, non-inferiority testing confirmed that HiSS was not worse than DCE-MRI.
CADx of HiSS (without contrast) performed similarly to CADx on clinical DCE-MRI; thus, computerized analysis of HiSS may provide sufficient information for diagnostic classification. The results are clinically important for patients in whom contrast agent is contra-indicated. Even in the limited acquisition mode of 2D single slice HiSS, by using quantitative image analysis to extract characteristics from the HiSS images, similar performance levels were obtained as compared to those from current clinical 4D DCE-MRI. As HiSS acquisitions become possible in 3D, CADx methods can also be applied. Since HiSS and DCE-MRI are based on different contrast mechanisms, the use of the two protocols in combination may increase diagnostic accuracy.
PMCID: PMC4143529  PMID: 24023011
High spectral and spatial resolution (HiSS) MRI; computer-aided diagnosis (CADx); breast cancer; dynamic contrast enhanced MRI (DCE-MRI); contrast-agent induced nephrotoxicity

Results 1-25 (609)