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1.  Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. in vitro 
This study examined the direct interaction of serotonin (5-hydroxytryptamine (5-HT)) with Aspergillus species. Accumulation of 5-HT in aspergilli was investigated by immunofluorescence staining and laser confocal scanning microscopy. The influence of 5-HT on fungal ergosterol content, cell membrane integrity, fungal growth and hyphal elongation was determined. 5-HT was localised in the cytoplasm of Aspergillus spp., as 5-HT fluorescent signals appeared after 30 min at 4°C and in the presence of inhibitors of oxidative phosphorylation. 5-HT treatment of Aspergillus spp. significantly affected ergosterol synthesis, fungal cell membrane integrity and hyphal elongation (P < 0.05). 5-HT treatment for 4 h resulted in a lag of re-growth (post-antifungal effect). In conclusion, our findings suggest that 5-HT affects hyphal growth and diminishes fungal cell membrane integrity.
PMCID: PMC3010239  PMID: 17276041
Serotonin; Aspergillus spp.; Ergosterol; Platelets
2.  Altitude sickness 
BMJ : British Medical Journal  2003;327(7406):106.
PMCID: PMC1126467  PMID: 12855541

Results 1-2 (2)