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1.  Interaction of serotonin with Candida albicans selectively attenuates fungal virulence in vitro 
In this study we investigated whether the direct interaction between Candida albicans CBS 5982 and 5-hydroxytryptamine (5-HT) alters candidial virulence. Hyphae elongation, phospholipase activity and the production of secreted aspartyl proteinases (Saps) following 5-HT treatment were investigated. 5-HT treatment of C. albicans significantly (P < 0.05) affected hyphal extension, phospholipase activity and the production of Saps at concentrations of 118–0.46 mM. In conclusion, our findings suggest that the interaction between 5-HT and C. albicans may diminish the virulence properties of this fungal pathogen.
doi:10.1016/j.ijantimicag.2005.07.006
PMCID: PMC2980867  PMID: 16157477
Candida albicans; 5-Hydroxytryptamine (5-HT); Virulence factor; Antifungal activity

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