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author:("Li, jianji")
1.  Structure-Guided Design of a Methyl Donor Cofactor that Controls a Viral Histone H3 Lysine 27 Methyltransferase Activity 
Journal of Medicinal Chemistry  2011;54(21):7734-7738.
vSET (a viral SET domain protein) is an attractive Polycomb Repressive Complex 2 (PRC2) surrogate to study the effect of histone H3 lysine 27 (H3K27) methylation on gene transcription as both catalyze histone H3K27 tri-methylation. In order to control the enzymatic activity of vSET in vivo with an engineered S-adenosyl-L-methionine (SAM) analogue as methyl donor cofactor, we have carried out structure-guided design, synthesis and characterization of orthogonal vSET methyltransferase mutant/SAM analogue pairs using a “bump-and-hole” strategy.
doi:10.1021/jm201000j
PMCID: PMC3326379  PMID: 21958314

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