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1.  Complete Genome Sequence of a Novel Mutation of Seoul Virus Isolated from Suncus murinus in the Fujian Province of China 
Genome Announcements  2015;3(2):e00075-15.
Suncus murinus has been identified as the host for Seoul virus (SEOV). Here, we report the complete genome sequence of SEOV strain Fj372/2013, which was isolated from the lung tissue of Suncus murinus in the Fujian Province of China. A mutation A38C was observed in an open reading fragment of the middle segment.
PMCID: PMC4384476  PMID: 25838472
2.  Electron-Phonon Coupling and its implication for the superconducting topological insulators 
Scientific Reports  2015;5:8964.
The recent observation of superconductivity in doped topological insulators has sparked a flurry of interest due to the prospect of realizing the long-sought topological superconductors. Yet the understanding of underlying pairing mechanism in these systems is far from complete. Here we investigate this problem by providing robust first-principles calculations of the role of electron-phonon coupling for the superconducting pairing in the prime candidate CuxBi2Se3. Our results show that electron-phonon scattering process in this system is dominated by zone center and boundary optical modes, with coexistence of phonon stiffening and softening. While the calculated electron-phonon coupling constant λ suggests that Tc from electron-phonon coupling is 2 orders smaller than the ones reported on bulk inhomogeneous samples, suggesting that superconductivity may not come from pure electron-phonon coupling. We discuss the possible enhancement of superconducting transition temperature by local inhomogeneity introduced by doping.
PMCID: PMC4354041  PMID: 25753813
3.  Statin use and risk of kidney cancer: a meta-analysis of observational studies and randomized trials 
Clinical studies have shown that statin use may modify the risk of kidney cancer. However, these studies yielded different results. To quantify the association between statin use and risk of kidney cancer, we performed a detailed meta-analysis of published studies regarding this subject.
A literature search was carried out using MEDLINE, EMBASE and the Cochrane database between January 1966 and October 2012. Prior to performing a meta-analysis, the studies were evaluated for publication bias and heterogeneity. Fixed effect and random effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analysis were also performed.
A total of 12 (two randomized controlled trials, five cohort, and five case–control) studies contributed to the analysis. There was heterogeneity among the studies but no evidence of publication bias. Pooled results indicated a non-significant decrease of total kidney cancer risk among all statin users (RR = 0.92, 95% CI 0.71, 1.19). Long term statin use did not significantly affect the risk of total kidney cancer (RR = 1.01, 95% CI 0.83, 1.22). In our subgroup analyses, the results were not substantially affected by study design, confounder adjustment and gender. Furthermore, sensitivity analysis confirmed the stability of the results.
The findings of this meta-analysis suggested that there was no association between statin use and risk of kidney cancer. More studies, especially randomized controlled trials and high quality cohort studies with larger sample size and well controlled confounding factors, are needed to confirm this association in the future.
PMCID: PMC3952720  PMID: 23879311
kidney cancer; meta-analysis; risk; statin
4.  Genetic alterations and expression of inhibitor of growth 1 in human sporadic colorectal cancer 
AIM: To explore the effect and significance of inhibitor of growth 1 (ING1) gene in carcinogenesis and progression of human sporadic colorectal cancer.
METHODS: mRNA expression, mutation, and loss of heterozygosity (LOH) of ING1 gene in 35 specimens of sporadic colorectal cancer tissues and the matched normal mucous membrane tissues were detected by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), PCR-single strain conformation polymorphism (PCR-SSCP) and PCR-simple sequence length polymorphism (PCR-SSLP) using microsatellite markers, respectively.
RESULTS: The average ratios of light intensities of p33ING1b and p47ING1a mRNA expression in the cancerous tissues were significantly lower than those in normal tissues. The difference between the two mRNA splices was not significant in the matched tissues. In addition, the ratios of light intensities of p33ING1b and p47ING1a mRNA expression in the cancerous tissues of Dukes?stages C and D were significantly lower than those in cancerous tissues of Dukes?stages A and B. However, no mutation of ING1 gene was detected in all 35 cases; only 4 cases of LOH (11.4%) were found.
CONCLUSION: p33ING1b and p47ING1a mRNA expressions are closely related with the carcinogenesis and progression of human sporadic colorectal cancer. No mutation of ING1 gene is found, and there are only few LOH in sporadic colorectal cancers. These might not be the main reasons for the down regulation of ING1 expression. Its low expression may happen in transcription or post-transcription.
PMCID: PMC4436627  PMID: 16273637
Colorectal cancer; Inhibitor of growth 1 (ING1); Expression; Mutation; Loss of heterozygosity
6.  Quantum Anomalous Hall Effect and Tunable Topological States in 3d Transition Metals Doped Silicene 
Scientific Reports  2013;3:2908.
Silicene is an intriguing 2D topological material which is closely analogous to graphene but with stronger spin orbit coupling effect and natural compatibility with current silicon-based electronics industry. Here we demonstrate that silicene decorated with certain 3d transition metals (Vanadium) can sustain a stable quantum anomalous Hall effect using both analytical model and first-principles Wannier interpolation. We also predict the quantum valley Hall effect and electrically tunable topological states could be realized in certain transition metal doped silicene where the energy band inversion occurs. Our findings provide new scheme for the realization of quantum anomalous Hall effect and platform for electrically controllable topological states which are highly desirable for future nanoelectronics and spintronics application.
PMCID: PMC3793221  PMID: 24105063
7.  Correction: Aspirin Use and Risk of Age-Related Macular Degeneration: A Meta-Analysis 
PLoS ONE  2013;8(6):10.1371/annotation/bc36f952-ec0c-45d0-bedd-15429017791e.
PMCID: PMC3692953
8.  Complete Genome Sequence of an Amur Virus Isolated from Apodemus peninsulae in Northeastern China 
Journal of Virology  2012;86(24):13816-13817.
Amur virus was recently identified as the causative agent of hemorrhagic fever with renal syndrome. Here we report the complete genome sequence of an Amur virus isolated from Apodemus peninsulae in Northeastern China. The sequence information provided here is critical for the molecular epidemiology and evolution of Amur virus in China.
PMCID: PMC3503078  PMID: 23166234
9.  Complete Genome Sequence of Seoul Virus Isolated from Rattus norvegicus in the Democratic People's Republic of Korea 
Journal of Virology  2012;86(24):13853.
Seoul virus (SEOV) is responsible for 25% of cases of hemorrhagic fever with renal syndrome in Asia. Here we report the complete genome of strain DPRK08. The sequence information provided here is useful for understanding the molecular character of SEOV in the Democratic People's Republic of Korea (DPRK) and the circulation of SEOV in East Asia.
PMCID: PMC3503101  PMID: 23166256
10.  Complete Genome Sequence of Wohlfahrtiimonas chitiniclastica Strain SH04, Isolated from Chrysomya megacephala Collected from Pudong International Airport in China 
Genome Announcements  2013;1(2):e00119-13.
Wohlfahrtiimonas chitiniclastica bacilli that live in the larvae of a parasitic fly were recently isolated and are speculated to be the cause of fulminant sepsis. Here we report and analyze the complete genome sequence of Wohlfahrtiimonas chitiniclastica strain SH04. No complete genome sequence of a Wohlfahrtiimonas chitiniclastica isolate has been documented previously.
PMCID: PMC3622979  PMID: 23558531
11.  Aspirin Use and Risk of Age-Related Macular Degeneration: A Meta-Analysis 
PLoS ONE  2013;8(3):e58821.
Age-related macular degeneration (AMD) is the main cause of blindness and the curative options are limited. The objective of this meta-analysis was to determine the association between aspirin use and risk of AMD.
A comprehensive literature search was performed in PubMed, Embase, Web of Science, and reference lists. A meta-analysis was performed by STATA software.
Ten studies involving 171729 individuals examining the association between aspirin use and risk of AMD were included. Among the included studies, 2 were randomized-controlled trials (RCTs), 4 were case-control studies and 4 were cohort studies. The relative risks (RRs) were pooled using a random-effects model. Relative risks with 95% confidence intervals (CIs) of aspirin use as a risk for AMD. The pooled RR of 10 included studies between the use of aspirin and risk of AMD was 1.09 (95% CI, 0.96–1.24). The same result was detected in early and late stage AMD subgroup analysis. In the subgroup analyses, the pooled RR of RCTs, case-control studies and cohort studies were 0.81 (95% CI, 0.64–1.02), 1.02 (95% CI, 0.92–1.14) and 1.08 (95% CI, 0.91–1.28), respectively.
The use of aspirin was not associated with the risk of AMD.
PMCID: PMC3597550  PMID: 23516561
12.  Indocyanine Green-Assisted Internal Limiting Membrane Peeling in Macular Hole Surgery: A Meta-Analysis 
PLoS ONE  2012;7(11):e48405.
The opinion of application of indocyanine green (ICG) in the macular hole surgery was contradictory. Here we conducted a meta-analysis to evaluate the effect of in internal limiting membrane (ILM) peeling for macular hole surgery.
Methods and Findings
We searched electronic databases for comparative studies published before July 2012 of ILM peeling with and without ICG. Twenty-two studies including 1585 eyes were included. Visual acuity (VA) improvement, including the postoperative rate of ≥20/40 VA gained (OR, 0.65; 95% CI, 0.43 to 0.97; P = 0.033) and increased LogMAR (WMD, −0.09; 95% CI, −0.16 to −0.02; P = 0.011), was less in the ICG group. The risk of visual field defects was greater in the ICG group than in the non-ICG group. There was no significant difference in the rate of anatomical outcomes between ILM peeling procedures performed with and without ICG. RPE changes and other postoperative complications were not significantly different between the ICG and non-ICG groups. An additional analysis showed that the VA improvement of the ICG group was less than the non-ICG group only within the first year of follow up. A subgroup analysis showed that the rate of VA improvement was lower in the ICG group than in other adjuncts group. A higher rate of secondary closure and less VA improvement were observed in a high proportion (>0.1%) of the ICG group. A sensitivity analysis after the randomized-controlled trials were excluded from the meta-analysis demonstrated no differences compared with the overall results.
This meta-analysis demonstrated that there is no evidence of clinical superiority in outcomes for ICG-assisted ILM peeling procedure over the non-ICG one. The toxicity of ICG should be considered when choosing the various staining methods.
PMCID: PMC3492355  PMID: 23144875

Results 1-12 (12)