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1.  From Research to Health Policy Impact 
Health Services Research  2012;47(1 Pt 2):337-343.
PMCID: PMC3393010  PMID: 22239662
2.  Building a Bridge to Somewhere Better: Linking Health Care Research and Health Policy 
Health Services Research  2012;47(1 Pt 2):329-336.
PMCID: PMC3393014  PMID: 22239661
3.  Women’s Health During Health Care Transformation 
Journal of General Internal Medicine  2013;28(Suppl 2):500-503.
PMCID: PMC3695281  PMID: 23807056
4.  Patient Engagement in Health Care 
Health Services Research  2011;46(2):389-393.
PMCID: PMC3064908  PMID: 21371026
5.  Can Incentives to Improve Quality Reduce Disparities? 
Health Services Research  2010;45(1):1-5.
PMCID: PMC2813433  PMID: 20459588
6.  Current Guidelines Have Limited Applicability to Patients with Comorbid Conditions: A Systematic Analysis of Evidence-Based Guidelines 
PLoS ONE  2011;6(10):e25987.
Guidelines traditionally focus on the diagnosis and treatment of single diseases. As almost half of the patients with a chronic disease have more than one disease, the applicability of guidelines may be limited. The aim of this study was to assess the extent that guidelines address comorbidity and to assess the supporting evidence of recommendations related to comorbidity.
Methodology/Principal Findings
We conducted a systematic analysis of evidence-based guidelines focusing on four highly prevalent chronic conditions with a high impact on quality of life: chronic obstructive pulmonary disease, depressive disorder, diabetes mellitus type 2, and osteoarthritis. Data were abstracted from each guideline on the extent that comorbidity was addressed (general comments, specific recommendations), the type of comorbidity discussed (concordant, discordant), and the supporting evidence of the comorbidity-related recommendations (level of evidence, translation of evidence). Of the 20 guidelines, 17 (85%) addressed the issue of comorbidity and 14 (70%) provided specific recommendations on comorbidity. In general, the guidelines included few recommendations on patients with comorbidity (mean 3 recommendations per guideline, range 0 to 26). Of the 59 comorbidity-related recommendations provided, 46 (78%) addressed concordant comorbidities, 8 (14%) discordant comorbidities, and for 5 (8%) the type of comorbidity was not specified. The strength of the supporting evidence was moderate for 25% (15/59) and low for 37% (22/59) of the recommendations. In addition, for 73% (43/59) of the recommendations the evidence was not adequately translated into the guidelines.
Our study showed that the applicability of current evidence-based guidelines to patients with comorbid conditions is limited. Most guidelines do not provide explicit guidance on treatment of patients with comorbidity, particularly for discordant combinations. Guidelines should be more explicit about the applicability of their recommendations to patients with comorbidity. Future clinical trials should also include patients with the most prevalent combinations of chronic conditions.
PMCID: PMC3197602  PMID: 22028802
7.  Building the Path to High-Quality Care 
Health Services Research  2009;44(1):1-4.
PMCID: PMC2669638  PMID: 19146563
8.  The Performance of Performance Measurement 
Health Services Research  2007;42(5):1797-1801.
PMCID: PMC2254569  PMID: 17850520
9.  Commentary: A Progress Report on AHRQ's Effective Health Care Program 
Health Services Research  2007;42(5):xi-xix.
PMCID: PMC2254568  PMID: 17850519
12.  Emergency Departments in Crisis: Opportunities for Research 
Health Services Research  2007;42(1 Pt 1):xiii-xx.
PMCID: PMC1955233  PMID: 17355577
14.  AHRQs National Healthcare Quality and Disparities Reports: Resources for Health Services Researches 
Health Services Research  2006;41(2):xiii-xix.
PMCID: PMC1702521  PMID: 16584450
15.  Clinical Research Training: Scientific Literacy for the Twenty-First Century 
PMCID: PMC2231410  PMID: 18183469
16.  Clinical Research Training: Scientific Literacy for the Twenty-First Century 
PMCID: PMC2231410  PMID: 18183469
17.  Research Funding Opportunities: Fiscal Year 2006 
Health Services Research  2005;40(5 Pt 1):xi-xiv.
PMCID: PMC1361213  PMID: 16174132
18.  The Persistent Challenge of Avoidable Hospitalizations 
Health Services Research  2005;40(4):953-956.
PMCID: PMC1361197  PMID: 16033486
19.  From Information on Quality to Quality Information 
Health Services Research  2004;39(6 Pt 1):1631-1634.
PMCID: PMC1361089  PMID: 15533178
20.  Evidence-based Health Care 2004: AHRQ Moves Research to Translation and Implementation 
Health Services Research  2004;39(5):xv-xxiv.
PMCID: PMC1361066  PMID: 15333128
21.  Consumer-Driven Health Care—Beyond Rhetoric with Research and Experience 
Health Services Research  2004;39(4 Pt 2):1055-1070.
PMCID: PMC1361052
22.  AHRQ's FY 2005 Budget Request: New Mission, New Vision 
Health Services Research  2004;39(3):xi-xviii.
PMCID: PMC1361016
24.  AHRQ's Bioterrorism Research Portfolio: Real Linkages in Real Time 
Health Services Research  2004;39(1):xi-xvi.
PMCID: PMC1360989  PMID: 14965073
25.  Primary Care Experience 
Journal of General Internal Medicine  2004;19(10):1064-1065.
PMCID: PMC1492575  PMID: 15482561

Results 1-25 (40)