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1.  Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn disease susceptibility 
Nature genetics  2007;39(7):830-832.
A genome-wide association scan in Crohn disease by the Wellcome Trust Case Control Consortium1 detected strong association at 6 novel loci. We tested 37 SNPs from these and other loci for association in an independent case control sample. Replication was obtained for the IRGM gene on chromosome 5q33.1 which induces autophagy (replication P = 6.6 × 10−4, combined P = 2.1 × 10−10), and for 9 other loci including NKX2-3 and gene deserts on chromosomes 1q and 5p13.
doi:10.1038/ng2061
PMCID: PMC2628541  PMID: 17554261
2.  A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 
Nature genetics  2007;39(7):827-829.
We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 × 10−7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5' of IL21, meta-analysis P=1.3 × 10−14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.
doi:10.1038/ng2058
PMCID: PMC2274985  PMID: 17558408

Results 1-2 (2)