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1.  Changes in Selenoprotein P in Substantia Nigra and Putamen in Parkinson’s Disease 
Journal of Parkinson's disease  2012;2(2):115-126.
Oxidative stress and oxidized dopamine contribute to the degeneration of the nigrostriatal pathway in Parkinson’s disease (PD). Selenoproteins are a family of proteins containing the element selenium in the form of the amino acid selenocysteine, and many of these proteins have antioxidant functions. We recently reported changes in expression of the selenoprotein, phospholipid hydroperoxide glutathione peroxidase GPX4 and its co-localization with neuromelanin in PD brain. To further understand the changes in GPX4 in PD, we examine here the expression of the selenium transport protein selenoprotein P (Sepp1) in postmortem Parkinson’s brain tissue. Sepp1 in midbrain was expressed in neurons of the substantia nigra (SN), and expression was concentrated within the centers of Lewy bodies, the pathological hallmark of PD. As with GPX4, Sepp1 expression was significantly reduced in SN from PD subjects compared with controls, but increased relative to cell density. In putamen, Sepp1 was found in cell bodies and in dopaminergic axons and terminals, although levels of Sepp1 were not altered in PD subjects compared to controls. Expression levels of Sepp1 and GPX4 correlated strongly in the putamen of control subjects but not in the putamen of PD subjects. These findings indicate a role for Sepp1 in the nigrostriatal pathway, and suggest that local release of Sepp1 in striatum may be important for signaling and/or synthesis of other selenoproteins such as GPX4.
PMCID: PMC3527083  PMID: 23268326
Selenium; selenoproteins; selenoprotein P; GPX4; glutathione peroxidase; Parkinson’s disease; Lewy bodies; dopamine; substantia nigra; striatum; putamen; presynaptic terminals
2.  Retinal image registration and comparison for clinical decision support 
The Australasian Medical Journal  2012;5(9):507-512.
For eye diseases, such as glaucoma and age-related macular degeneration (ARMD), involved in long-term degeneration procedure, longitudinal comparison of retinal images is a common step for reliable diagnosis of these kinds of diseases.
To provide a retinal image registration approach for longitudinal retinal image alignment and comparison.
Two image registration solutions were proposed for facing different image qualities of retinal images to make the registration methods more robust and feasible in a clinical application system.
Thirty pairs of longitudinal retinal images were used for the registration test. The experiments showed both solutions provided good performance for the accurate image registrations with efficiency.
We proposed a set of retinal image registration solutions for longitudinal retinal image observation and comparison targeting a clinical application environment.
PMCID: PMC3477780  PMID: 23115586
Retinal image registration; Glaucoma; ARMD; clinical decision support
3.  Characterization of Japanese-American men with a single neocortical AD lesion type 
Neurobiology of aging  2007;29(10):1448-1455.
Neocortical neuritic plaques (NP) and neurofibrillary tangles (NFT) are hallmarks of Alzheimer’s disease (AD) and usually, both are present. The Honolulu-Asia Aging Study autopsy series includes a significant number of individuals with only one neocortical AD lesion type. These could represent an early phase of the AD process. If so, such individuals would be expected to share other clinical and pathological features of AD. We compared frequency of apolipoprotein epsilon E4 (APOE4) allele, average Braak stage, and burden of cerebral amyloid angiopathy (CAA) among the two single lesion type groups, a group without AD lesions, and groups with high and low frequencies of both AD lesions. Single AD lesion groups shared only the characteristics associated with their unique lesion type with the combined AD lesion group and did not have higher prevalence of dementia than the no AD lesion group. Only the NP+NFT group showed a “dose response” relationship with greater probability of dementia with higher neocortical frequencies of either AD lesion. The single neocortical AD lesion groups do not appear to represent early AD.
PMCID: PMC2613368  PMID: 17499884
Alzheimer’s disease; Neocortical neuritic plaques; Neocortical neurofibrillary tangles; Braak stage; Apolipoprotein epsilon E4; Cerebral amyloid angiopathy

Results 1-3 (3)