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1.  Prevalence of diabetic nephropathy in an underserved rural community 
Indian Journal of Nephrology  2012;22(6):484-485.
doi:10.4103/0971-4065.106049
PMCID: PMC3573497  PMID: 23436962
2.  A retroperitoneal bronchogenic cyst: a rare cause of a mass in the adrenal region 
Journal of Clinical Pathology  2001;54(10):801-802.
This report documents a bronchogenic cyst presenting as an adrenal tumour in a 51 year old man with persistent epigastric pain. The cyst is regarded as a developmental abnormality of the primitive foregut, which typically occurs in the chest. Subdiaphragmatic, and retroperitoneal locations in particular, are unusual. The differential diagnosis of a bronchogenic cyst in the retroperitoneum includes cystic teratoma, bronchopulmonary sequestration, cysts of urothelial and mullerian origin, and other foregut cysts.
Key Words: bronchogenic cyst • retroperitoneum • adrenal • differential diagnosis
PMCID: PMC1731290  PMID: 11577133
3.  Current status of transjugular intrahepatic portosystemic shunts. 
Postgraduate Medical Journal  1998;74(878):716-720.
The use of the transjugular intrahepatic portosystemic shunt (TIPS) has emerged as an important nonoperative modality for variceal bleeding, intractable ascites, and for selected cases of hepatic venous obstruction. We believe that TIPS should be viewed as a 'bridge' to liver transplantation and should be carried out only in experienced centres. The adverse haemodynamic changes on the cardiopulmonary system after TIPS should be borne in mind. Prospective trials to evaluate the role of TIPS versus sclerotherapy in variceal bleeding will be watched with interest. There is, however, an urgent need to improve long-term results of TIPS as stent thrombosis and stenosis occur frequently. We advocate routine surveillance to detect these problems at an early stage.
PMCID: PMC2431632  PMID: 10320885
4.  Post-transplant hyperlipidaemia. 
Postgraduate Medical Journal  1997;73(866):785-793.
The correction of post-transplant hyperlipidaemia warrants the judicious and timely use of pharmacological agents with dietary modification and exercise. Reduction in hyperlipidaemia may have some role in decreasing the incidence of chronic rejection of allografts. The awareness that the morbidity and mortality of atherosclerotic disease may be lowered by active intervention will result in a better quality of life for transplant recipients.
PMCID: PMC2431514  PMID: 9497947
5.  Preliminary randomized double-blind placebo-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects. 
OBJECTIVE: Because the initial phase of treatment of depression with a selective serotonin reuptake inhibitor is often complicated by a delayed onset of action of the antidepressant or severe insomnia or both, we investigated whether tryptophan, an amino acid with both antidepressant-augmenting and hypnotic effects, would benefit patients with depression at the beginning of treatment with fluoxetine. DESIGN: Randomized, double-blind, placebo-controlled trial. PATIENTS: Thirty individuals with major depressive disorder. INTERVENTIONS: Treatment over 8 weeks with 20 mg of fluoxetine per day and either tryptophan (2 to 4 g per day) or placebo. OUTCOME MEASURES: Mood was assessed using the 29-item Hamilton Depression Rating Scale (HDRS-29) and the Beck Depression Inventory (BDI). Laboratory sleep studies were done at baseline and after 4 and 8 weeks of treatment using standard procedures. RESULTS: During the first week of treatment, there was a significantly greater decrease in HDRS-29 depression scores, and a similar trend in BDI scores, in the tryptophan/fluoxetine group than in the placebo/fluoxetine group. No significant differences were noted at later time points. With respect to sleep measures, there was a significant group-by-time interaction for slow-wave sleep at week 4. Further analysis revealed a significant decrease in slow-wave sleep after 4 weeks of treatment in the placebo/fluoxetine group, but not in the tryptophan/fluoxetine group. No cases of serotonin syndrome occurred, and the combination was well tolerated, although the 4 g per day dosage of tryptophan produced daytime drowsiness. CONCLUSIONS: Combining 20 mg of fluoxetine with 2 g of tryptophan daily at the outset of treatment for major depressive disorder appears to be a safe protocol that may have both a rapid antidepressant effect and a protective effect on slow-wave sleep. Further large-scale studies are needed to confirm these initial findings.
PMCID: PMC1407729  PMID: 11022398
6.  The role of cell migration and microchimerism in the induction of tolerance after solid organ transplantation. 
Postgraduate Medical Journal  1997;73(857):146-150.
A new hypothesis has been proposed which states that microchimerism is the basis for the clinical tolerance seen in long-term survivors of solid organ transplants. Efforts to enhance microchimerism include simultaneous infusion of bone marrow of donor origin and transplantation of a solid organ. Studies are in progress to verify the phenomenon of microchimerism and its role in clinical tolerance.
PMCID: PMC2431236  PMID: 9135829
7.  Renal dysfunction associated with liver transplantation. 
Postgraduate Medical Journal  1995;71(839):513-524.
It has been known for some time that a variety of liver diseases affect kidney function, but renal dysfunction associated with orthotopic liver transplantation has received scant attention. Although the mechanisms mediating these abnormalities are incompletely defined, advances in the understanding of renal pathophysiology after liver transplantation have made it possible to develop new treatment strategies. Aggressive and early intervention to diagnose and treat renal complications associated with liver transplantation should be the goal for transplant centres.
PMCID: PMC2398230  PMID: 7479462
8.  Central pontine myelinolysis following orthotopic liver transplant: association with cyclosporine toxicity. 
Postgraduate Medical Journal  1995;71(834):239-241.
Central pontine myelinolysis can occur after orthotopic liver transplantation leading to high mortality and serious morbidity. In our case, central pontine myelinolysis was associated with wide fluctuations in cyclosporine levels during an episode of hypocholesterolaemia, which may have precipitated central pontine myelinolysis.
Images
PMCID: PMC2398070  PMID: 7784287
9.  Pancreatic islet transplantation for diabetes. 
Postgraduate Medical Journal  1994;70(827):665-666.
PMCID: PMC2397756  PMID: 7971637
10.  Osteomyelitis of symphysis pubis following renal transplantation. 
Postgraduate Medical Journal  1993;69(815):742-744.
We describe what we believe is the first reported case of osteomyelitis of the symphysis pubis following renal transplantation. Computed tomographic and magnetic resonance imaging scans were useful in establishing the diagnosis.
Images
PMCID: PMC2399792  PMID: 8255848
12.  Buerger's disease in western India. 
Postgraduate Medical Journal  1993;69(810):326-327.
PMCID: PMC2399643  PMID: 7686671
14.  A STUDY OF PSYCHIATRIC REFERRALS IN A GENERAL HOSPITAL 
Indian Journal of Psychiatry  1980;22(1):108-110.
SUMMARY
In-patient as well as out-patient psychiatric referrals at Safdarjang Hospital, New Delhi were studied during a short period of 2½ months. The data were analysed with respect to referral rate, sources of referral and psychiatric diagnosis as made by the referring unit, compared with the diagnosis arrived at the department of Psychiatry. The results have been discussed in the study.
PMCID: PMC3013324  PMID: 22058450

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