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1.  The amyloid fold of Gad m 1 epitopes governs IgE binding 
Scientific Reports  2016;6:32801.
Amyloids are polymeric structural states formed from locally or totally unfolded protein chains that permit surface reorganizations, stability enhancements and interaction properties that are absent in the precursor monomers. β-Parvalbumin, the major allergen in fish allergy, forms amyloids that are recognized by IgE in the patient sera, suggesting a yet unknown pathological role for these assemblies. We used Gad m 1 as the fish β-parvalbumin model and a combination of approaches, including peptide arrays, recombinant wt and mutant chains, biophysical characterizations, protease digestions, mass spectrometry, dot-blot and ELISA assays to gain insights into the role of amyloids in the IgE interaction. We found that Gad m 1 immunoreactive regions behave as sequence-dependent conformational epitopes that provide a 1000-fold increase in affinity and the structural repetitiveness required for optimal IgE binding and cross-linking upon folding into amyloids. These findings support the amyloid state as a key entity in type I food allergy.
doi:10.1038/srep32801
PMCID: PMC5011719  PMID: 27597317
2.  7th Drug hypersensitivity meeting: part two 
Elera, Javier Dionicio | Boteanu, Cosmin | Blanco, Maria Aranzazu Jimenez | Gonzalez-Mendiola, Rosario | García, Irene Carrasco | Alvarez, Antonio | Martinez, Jose Julio Laguna | Garrido, Jaume Martí | Barona, Carla Torán | Chorda, Carolina Perales | Salgueiro, Ramón López | Palacios, Miguel Díaz | De Rojas, Dolores Hernández Fernández | Acar, Emre Ali | Aktas, Ayse | Ermertcan, Aylin Türel | Temiz, Peyker | Lin, Chien-Yio | Hui, Chung-Yee Rosaline | Chang, Ya-Ching | Yang, Chih-Hsun | Chung, Wen-Hung | Carolino, Fabrícia | Silva, Diana | De Castro, Eunice Dias | Cernadas, Josefina R. | Ensina, Luis Felipe | Aranda, Carolina | Nunes, Ines Camelo | Lacerda, Alex | Martins, Ana Maria | Goudouris, Ekaterini | Ribeiro, Marcia | Da Silva Franco, José Francisco | Queiroz, Leandra | Solé, Dirceu | Dalgiç, Ceyda Tunakan | Sin, Aytül Zerrin | Günsen, Fatma Düsünür | Bulut, Gökten | Ardeniz, Fatma Ömür | Gülbahar, Okan | Gökmen, Emine Nihal Mete | Kokuludag, Ali | De Francisco, Ana M. Montoro | De Vicente Jiménez, Talía Mª | Mendoza Parra, Adriana M. | Burgos Pimentel, Angella M. | Luque, Amelia García | Amaral, Luis | Leão, Leonor Carneiro | Pinto, Nicole | Belo, Joana | Marques, João | Carreiro-Martins, Pedro | Leiria-Pinto, Paula | Chaabane, Amel | Romdhane, Haifa Ben | Fredj, Nadia Ben | Chadly, Zohra | Boughattas, Naceur A. | Aouam, Karim | Uyttebroek, Astrid P. | Bridts, Chris H. | Romano, Antonino | Ebo, Didier G. | Sabato, Vito | Lopes, Anabela | Cosme, Joana | Aguiar, Rita | Lourenço, Tatiana | Paes, Maria-João | Spínola-Santos, Amélia | Pereira-Barbosa, Manuel | Cruz, Cíntia Rito | Dos Reis, Rute Pereira | Tomaz, Elza | Pires, Ana Paula | Inácio, Filipe | Benito-Garcia, Filipe | Mota, Inês | Correia, Magna | Gaspar, Ângela | Chambel, Marta | Piedade, Susana | Morais-Almeida, Mário | Nakonechna, Alla | Antipkin, Yurij | Umanets, Tetiana | Pineda, Fernando | Arribas, Francisca | Lapshyn, Volodymyr | Miranda, Pablo Andrés | De La Cruz Hoyos, Bautista | Blanco, Aranzazu Jimenez | Del Pozo, Marta | Vultaggio, Alessandra | Nencini, Francesca | Pratesi, Sara | Matucci, Andrea | Maggi, Enrico | Cegec, Ivana | Nahal, Danica Juricic | Turk, Viktorija Erdeljic | Aumiler, Matea Radacic | Ausperger, Ksenija Makar | Kraljickovic, Iva | Simic, Iveta | Yamaguchi, Yukie | Watanabe, Tomoya | Satoh, Megumi | Tanegashima, Tomohiko | Oda, Kayoko | Wada, Hidefumi | Aihara, Michiko | Lee, Jaechun Jason | Choi, Jay Chol | Lee, Hwa Young | Fernandes, Rosa-Anita Rodrigues | Faria, Emília | Pita, Joana | Sousa, Nuno | Ribeiro, Carmelita | Carrapatoso, Isabel | Bom, Ana Todo | Rodolfo, Ana | Dias-Castro, Eunice | Voronova, Marina | Valle, Diana Kury | Coronel, Verónica Pacheco | Chordá, Carolina Perales | Madamba, Roselle Catherine Yu | Ferrer, Marta | Goikoetxea, Maria Jose | D’Amelio, Carmen | Bernad, Amalia | Vega, Olga | Gastaminza, Gabriel | Bibián, Beatriz Pola | Salazar, Marina Lluncor | Vilà-Nadal, Gemma | Roman, Ana María Fiandor | Ortega, Javier Dominguez | Muñoz, Miguel Gonzalez | Gancedo, Santiago Quirce | Moreno, Maria Rosario Cabañas | Hofmeier, Kathrin Scherer | Barzylovych, Vladyslava | Pola, Beatriz | Lluncor, Marina | Fiandor, Ana | Bellón, Teresa | Domínguez, Javier | Quirce, Santiago | Yang, Min-Suk | Kim, Sun-Sin | Kim, Sae-Hoon | Kang, Hye-Ryun | Park, Heung-Woo | Cho, Sang-Heon | Min, Kyung-Up | Chang, Yoon-Seok | Delahaye, Clémence | Flabbee, Jenny | Waton, Julie | Bauvin, Olivia | Barbaud, Annick | Fadhel, Najah Ben | Gulin, Sandra Jerkovic | Chiriac, Anca | Cardoso, Bárbara Kong | Viseu, Regina | Moreira, Ana | Cadinha, Susana | Neves, Ana Castro | Barreira, Patrícia | Malheiro, Daniela | Da Silva, J. P. Moreira | Jurakic-Toncic, Ružica | Ljubojevic, Suzana | Turcic, Petra | Gilissen, Liesbeth | Huygens, Sara | Goossens, An | Andreu, Inmaculada | Romero, Alicia Martinez | Cabezas, Pau Gomez | Parejo, Pedro Ayuso | Del Carmen Plaza-Serón, Maria | Doña, Inmaculada | Blanca-López, Natalia | Flores, Carlos | Galindo, María Luisa | Molina, Ana | Perkins, James Richard | Cornejo-García, José Antonio | García-Agúndez, José Augusto | García-Martín, Elena | Campo, Paloma | Canto, María Gabriela | Blanca, Miguel | Guéant-Rodríguez, Rosa María | Jurado-Escobar, Raquel | Barrionuevo, Esther | Salas, María | Canto, Gabriela | Guéant, Jean-Louis | Usui, Toru | Tailor, Arun | Faulkner, Lee | Farrell, John | Alfirevic, Ana | Kevin Park, B. | Naisbitt, Dean J. | Trelles, Oswaldo | Guerrero, María Auxiliadora | Upton, Alex | Ueta, Mayumi | Sawai, Hiromi | Sotozono, Chie | Tokunaga, Katushi | Kinoshita, Shigeru | Sukasem, Chonlaphat | Satapornpong, Patompong | Tempark, Therdpong | Rerknimitr, Pawinee | Pairayayutakul, Kulprapat | Klaewsongkram, Jettanong | Koomdee, N. | Jantararoungtong, T. | Santon, S. | Puangpetch, A. | Intusoma, U. | Tassaneeyakul, W. | Theeramoke, V. | Ramirez, Elena | Borobia, Alberto Manuel | Tong, Hoi | Castañer, Jose Luis | De Abajo, Francisco José | Galvao, Violeta Régnier | Pavlos, Rebecca | Mckinnon, Elizabeth | Williams, Kristina | Beeghly-Fadiel, Alicia | Redwood, Alec | Phillips, Elizabeth | Castells, Mariana | Boni, Elisa | Russello, Marina | Mauro, Marina | Ue, Kok Loong | Rutkowski, Krzysztof | Gomis, Victor Soriano | Ferre, Jorge Frances | Rodriguez, Angel Esteban | Reig, Vicente Cantó | Sanchez, Javier Fernandez | Breynaert, Christine | Van Hoeyveld, Erna | Schrijvers, Rik | Blanco, Aranzazu Jimenez | Irigoyen, Raquel Fuentes | Collado, Daniel | Vida, Yolanda | Najera, Francisco | Perez-Inestrosa, Ezequiel | Mesa-Antunez, Pablo | Mayorga, Cristobalina | Torres, María José | Tannert, Line K. | Mortz, Charlotte G. | Skov, Per Stahl | Bindslev-Jensen, Carsten | Pfützner, Wolfgang | Dörnbach, Hannah | Visse, Johanna | Rauber, Michele | Möbs, Christian | Elzagallaai, Abdelbaset A. | Chow, Lindsey | Abuzgaia, Awatif M. | Rieder, Michael J. | Trubiano, Jason | Woolnough, Emily | Stautins, Kaija | Cheng, Christina | Kato, Kenichi | Azukizawa, Hiroaki | Hanafusa, Takaaki | Katayama, Ichiro | Fujiyama, Toshiharu | Hashizume, Hideo | Umayahara, Takatsune | Ito, Taisuke | Tokura, Yoshiki | Silar, Mira | Zidarn, Mihaela | Rupnik, Helena | Korosec, Peter | Redwood, Alec James | Strautins, Kaija | White, Katie | Chopra, Abha | Konvinse, Katherine | Leary, Shay | Mallal, Simon | Cabañas, Rosario | Fiandor, Ana María | Sullivan, Andrew | Whitaker, Paul | Peckham, Daniel | Haw, Wei Yann | Polak, Marta E. | Mcguire, Carolann | Ardern-Jones, Michael R. | Aoyama, Yumi | Shiohara, Tetsuo | Correia, Sara | Gelincik, Asli | Demir, Semra | Sen, Fatma | Bozbey, Hamza Ugur | Olgac, Muge | Unal, Derya | Coskun, Raif | Colakoglu, Bahauddin | Buyuozturk, Suna | Çatin-Aktas, Esin | Deniz, Gunnur | Laguna, Jose Julio | Dionicio, J. | Fernandez, Tahia | Olazabal, I. | Ruiz, Maria Dolores | Torres, Maria José | Lafuente, Alberto | Núñez, Jorge | Fernández, Tahia Diana | Palomares, Francisca | Fernández, Rubén | Sanchez, Maria Isabel | Fernandez, Tahía | Ruiz, Arturo | Ariza, Adriana | Alonso, Amalia Bernad | Garófalo, Carmen D’Amelio | Matute, Olga Vega | Puga, Marta Ferrer | Lapresa, María José Goikoetxea | Lasarte, Gabriel Gastaminza | Thinnes, Antonia | Merk, Hans F. | Baron, Jens Malte | Leverkus, Martin | Balakirski, Galina | Gibson, Andrew | Ogese, Monday | Al-Attar, Zaid | Yaseen, Fiazia | Meng, Xiaoli | Jenkins, Rozalind | Farrel, John | Alhilali, Khetam | Xue, Yanni | Illing, Patricia | Mifsud, Nicole | Fettke, Heidi | Lai, Jeffrey | Ho, Rebecca | Kwan, Patrick | Purcell, Anthony | Ogese, Monday O. | Betts, Catherine | Thomson, Paul | Alhaidari, Mohammad | Berry, Neill | O’Neill, Paul M. | Alzahrani, Abdulaziz | Azoury, Marie Eliane | Fili, Lucia | Bechara, Rami | Scornet, Noémie | Nhim, Cathy | Weaver, Richard | Claude, Nancy | Joseph, Delphine | Maillere, Bernard | Parronchi, Paola | Pallardy, Marc | Villani, Axel Patrice | Rozières, Aurore | Bensaïd, Benoît | Tardieu, Mathilde | Albert, Floriane | Mutez, Virginie | Baysal, Tugba | Maryanski, Janet | Nicolas, Jean-François | Kanagawa, Osami | Vocanson, Marc | Hung, Shuen-Iu | Harrison, Caroline J. | Jenkins, Rosalind E. | French, Neil S. | Montañez, Maria Isabel | Fernandez, Tahia D. | Martin-Serrano, Angela | Torres, Maria Jose | Molina, Noemi | Wood, Sally | Pirmohamed, Munir | Montañez, María Isabel | Martín-Serrano, Ángela | Pérez-Inestrosa, Ezequiel | Pérez-Sala, Dolores | Guzmán, Antonio E. | Ko, Tai-Ming | Chen, Yuan-Tsong | Wu, Jer-Yuarn | Sánchez-Gómez, Francisco J. | González-Morena, Juan M. | Torres, María J. | Arreola, Alejandra Monroy | Corona, Jesus Agustin Badillo | Flores, Silvia Mendez | Cherit, Judith Dominguez | Figueroa, Noe Valentin Duran | Flores, Jose Luis Castrejon | Perkins, James | Pérez-Alzate, Diana | Bogas, Gador | Torres, María J | Marti, Luis Mario Tubella | De La Losa, Fernando Pineda | Poves, Francisca Arribas | Lopez, Jaime Tubella | Santiago, Teodora Lopez
Table of contents
Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)
P92 16 years of experience with proton pump inhibitors (PPIs)
Javier Dionicio Elera, Cosmin Boteanu, Maria Aranzazu Jimenez Blanco, Rosario Gonzalez-Mendiola, Irene Carrasco García, Antonio Alvarez, Jose Julio Laguna Martinez
P93 Allergy evaluation of quinolone induced adverse reactions
Jaume Martí Garrido, Carla Torán Barona, Carolina Perales Chorda, Ramón López Salgueiro, Miguel Díaz Palacios, Dolores Hernández Fernández De Rojas
P94 Bupropion-induced acute urticaria and angioedema, a case report
Emre Ali Acar, Ayse Aktas, Aylin Türel Ermertcan, Peyker Temiz
P96 Delayed type hypersensitivity and study of cross-reactivity between proton-pump inhibitors
Chien-Yio Lin, Chung-Yee Rosaline Hui, Ya-Ching Chang, Chih-Hsun Yang, Wen-Hung Chung
P97 Diagnostic work-up in suspected hypersensitivity to proton-pump inhibitors: looking at cross-reactivity
Fabrícia Carolino, Diana Silva, Eunice Dias De Castro, Josefina R. Cernadas
P98 Management of infusion-related hypersensitivity reactions to enzyme replacement therapy for lysosomal diseases
Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Alex Lacerda, Ana Maria Martins, Ekaterini Goudouris, Marcia Ribeiro, José Francisco Da Silva Franco, Leandra Queiroz, Dirceu Solé
P99 Management of insulin allergy with continuous subcutaneous insulin infusion
Ceyda Tunakan Dalgiç, Aytül Zerrin Sin, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Ali Kokuludag
P100 Off-label use of icatibant for management of serious angioedema associated with angiotensin inhibitors
Ana M. Montoro De Francisco, Talía Mª De Vicente Jiménez, Adriana M. Mendoza Parra, Angella M. Burgos Pimentel, Amelia García Luque
P101 Thiocolchicoside anaphylaxis: an unusual suspect?
Luis Amaral, Fabricia Carolino, Leonor Carneiro Leão, Eunice Castro, Josefina Cernadas
Poster walk 12: betalactam hypersensitivity (P102–P111)
P102 A curious delayed reading: a case report of a β-lactam allergy in a child
Nicole Pinto, Joana Belo, João Marques, Pedro Carreiro-Martins, Paula Leiria-Pinto
P103 Betalactam-induced hypersensitivity: a 10-years’ experience
Amel Chaabane, Haifa Ben Romdhane, Nadia Ben Fredj, Zohra Chadly, Naceur A. Boughattas, Karim Aouam
P104 Cefazolin hypersensitivity: towards optimized diagnosis
Astrid P. Uyttebroek, Chris H. Bridts, Antonino Romano, Didier G. Ebo, Vito Sabato
P105 Clavulanic acid allergy: two cases report
Anabela Lopes, Joana Cosme, Rita Aguiar, Tatiana Lourenço, Maria-João Paes, Amélia Spínola-Santos, Manuel Pereira-Barbosa
P106 Diagnosis of betalactam allergy in an allergy department
Cíntia Rito Cruz, Rute Pereira Dos Reis, Elza Tomaz, Ana Paula Pires, Filipe Inácio
P107 Diagnostic work-up of 410 patients with suspicion of betalactam antibiotic hypersensitivity
Filipe Benito-Garcia, Inês Mota, Magna Correia, Ângela Gaspar, Marta Chambel, Susana Piedade, Mário Morais-Almeida
P108 Immediate selective hypersensitivity reactions to clavulanic acid
Alla Nakonechna, Yurij Antipkin, Tetiana Umanets, Fernando Pineda, Francisca Arribas, Volodymyr Lapshyn
P109 Prevalence and incidence of penicillin hypersensitivity reactions in Colombia
Pablo Andrés Miranda, Bautista De La Cruz Hoyos
P110 Selective sensitization to amoxicilin and clavulanic acid
Jose Julio Laguna Martinez, Aranzazu Jimenez Blanco, Javier Dionicio Elera, Cosmin Boteanu, Rosario Gonzalez-Mendiola, Marta Del Pozo
P111 Infliximab-specific T cells are detectable also in treated patients who have not developed anti-drug antibodies
Alessandra Vultaggio, Francesca Nencini, Sara Pratesi, Andrea Matucci, Enrico Maggi
Poster walk 13: biologicals, local anesthetics, others (P112–P118)
P112 A case report of allergic immediate systemic reaction to adalimumab and certolizumab
Ceyda Tunakan Dalgiç, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Emine Nihal Mete Gökmen, Aytül Zerrin Sin, Ali Kokuludag
P113 Allergy to local anesthetics: negative predictive value of skin tests
Ivana Cegec, Danica Juricic Nahal, Viktorija Erdeljic Turk, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iva Kraljickovic, Iveta Simic
P114 Cutaneous adverse reactions of molecular targeted agents: a retrospective analysis in 150 patients in our department
Yukie Yamaguchi, Tomoya Watanabe, Megumi Satoh, Tomohiko Tanegashima, Kayoko Oda, Hidefumi Wada, Michiko Aihara
P115 Generalized paralysis induced by local lidocaine injection
Jaechun Jason Lee, Jay Chol Choi, Hwa Young Lee
P116 Hypersensitivity to local anaesthetics: a 10 year review
Rosa-Anita Rodrigues Fernandes, Emília Faria, Joana Pita, Nuno Sousa, Carmelita Ribeiro, Isabel Carrapatoso, Ana Todo Bom
P117 Local anaesthetics: a rare culprit in hypersensitivity reactions
Ana Rodolfo, Eunice Dias-Castro, Josefina Cernadas
P118 Stevens–Johnson syndrome in clinical practice: a variant of clinical course
Marina Voronova
Poster walk 14: RCM (P119–P128)
P119 13 cases of severe anaphylactic reactions due to radiocontrast media
Jaume Martí Garrido, Ramon Lopez Salgueiro, Diana Kury Valle, Verónica Pacheco Coronel, Carolina Perales Chordá, Dolores Hernandez Fernandez De Rojas
P120 Anaphylactic shock after administration of iodinated contrast medium during cardiac catheterization
Roselle Catherine Yu Madamba, Marta Ferrer, Maria Jose Goikoetxea, Carmen D’Amelio, Amalia Bernad, Olga Vega, Gabriel Gastaminza
P121 Anaphylactic shock and cardiac arrest induced by gadolinium-based contrast agents
Beatriz Pola Bibián, Marina Lluncor Salazar, Gemma Vilà Nadal, Ana María Fiandor Roman, Javier Dominguez Ortega, Miguel Gonzalez Muñoz, Santiago Quirce Gancedo, Maria Rosario Cabañas Moreno
P122 Anaphylaxis to gadobenate and cross-reactivity to other gadolinium-based contrast agents in two patients
Kathrin Scherer Hofmeier
P123 Anaphylaxis to glatiramer acetate in a patient with multiple sclerosis
Fabrícia Carolino, Vladyslava Barzylovych, Josefina R. Cernadas
P124 Delayed hypersensitivity reaction to radiocontrast media
Fabrícia Carolino, Diana Silva, Leonor Leão, Josefina R. Cernadas
P125 Drug reaction with eosinophilia and systemic symptoms induced by iodixanol
Gemma Vilà-Nadal, Beatriz Pola, Marina Lluncor, Ana Fiandor, Teresa Bellón, Javier Domínguez, Santiago Quirce
P126 Electronic consultation support system for radiocontrast media hypersensitivity changes clinician’s behavior
Min-Suk Yang, Sun-Sin Kim, Sae-Hoon Kim, Hye-Ryun Kang, Heung-Woo Park, Sang-Heon Cho, Kyung-Up Min, Yoon-Seok Chang
P127 Hypersensitivity reactions to iodinated contrast media: skin testing and follow-up
Danica Juricic Nahal, Ivana Cegec, Viktorija Erdeljic Turk, Iva Kraljickovic, Matea Radacic Aumiler, Ksenija Makar Ausperger, Iveta Simic
P128 Would iodine allergy exist?
Clémence Delahaye, Jenny Flabbee, Julie Waton, Olivia Bauvin, Annick Barbaud
Poster walk 15: MPE/type 4 (P129–P137)
P129 Delayed hypersensitivity cutaneous reactions: a case/control study from a tunisian database
Karim Aouam, Najah Ben Fadhel, Zohra Chadly, Nadia Ben Fredj, Naceur A. Boughattas, Amel Chaabane
P130 Delayed hypersensitivity reactions to cephalosporins: a review of seven cases
Joana Cosme, Anabela Lopes, Amélia Spínola-Santos, Manuel Pereira-Barbosa
P131 Diclofenac induced allergic contact dermatitis: case series of four patients
Sandra Jerkovic Gulin, Anca Chiriac
P132 Late-onset maculopapular rash to irbesartan
Bárbara Kong Cardoso, Elza Tomaz, Regina Viseu, Filipe Inácio
P133 Nonimmediate hypersensitivity reactions to betalactams: a retrospective analysis
Ana Moreira, Susana Cadinha, Ana Castro Neves, Patricia Barreira, Daniela Malheiro, J. P. Moreira Da Silva
P134 Occupational airborne contact dermatitis to omeprazole
Ružica Jurakic-Toncic, Suzana Ljubojevic, Petra Turcic
P135 Ornidazole-induced fixed drug eruption confirmed by positive patch test on a residual pigmented lesion
Liesbeth Gilissen, Sara Huygens, An Goossens
P136 Repeated delayed reaction induced by amoxicillin and amoxicillin clavulanate
Inmaculada Andreu, Ramon Lopez-Salgueiro, Alicia Martinez Romero, Pau Gomez Cabezas
P137 Systemic photosensitivity from fenofibrate in a patient photo-sensitized to ketoprofen
Liesbeth Gilissen, An Goossens
Poster walk 16: HLA genetics (P138–P146)
P138 A copy number variation in ALOX5 and PTGER1 is associated with nonsteroidal anti-inflammatory drugs induced urticaria and/or angioedema
Pedro Ayuso Parejo, Maria Del Carmen Plaza-Serón, Inmaculada Doña, Natalia Blanca López, Carlos Flores, Luisa Galindo, Ana Molina, James Richard Perkins, Jose Antonio Cornejo-García, José Augusto García-Agúndez, Elena García-Martín, Paloma Campo, María Gabriela Canto, Miguel Blanca
P139 Association of galectin-3 (LGALS3) single nucleotide polymorphisms with non-steroidal anti-inflammatory drugs-induced urticaria/angioedema
José Antonio Cornejo-Garcia, Inmaculada Doña, Rosa María Guéant-Rodríguez, Natalia Blanca-López, María Carmen Plaza-Serón, Raquel Jurado-Escobar, Esther Barrionuevo, María Salas, María Luisa Galindo, Gabriela Canto, Miguel Blanca, Jean-Louis Guéant
P140 Detection of T cell responses to ticlopidine using peripheral blood mononuclear cells from HLA-A*33:03+ healthy donors
Toru Usui, Arun Tailor, Lee Faulkner, John Farrell, Ana Alfirevic, B. Kevin Park, Dean J. Naisbitt
P141 Epistasis approaches to identify novel genes potentially involved in NSAIDs hypersensitivity
James Richard Perkins, Jose Antonio Cornejo García, Oswaldo Trelles, Inmaculada Doña, Esther Barrionuevo, María Salas, María Auxiliadora Guerrero, Miguel Blanca, Alex Upton
P142 Genetic predisposition of cold medicine related SJS/TEN with severe ocular complications
Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru Kinoshita
P143 HLA-B*13:01 and dapsone induced hypersensitivity in Thai population
Chonlaphat Chonlaphat Sukasem, Patompong Satapornpong, Therdpong Tempark, Pawinee Rerknimitr, Kulprapat Pairayayutakul, Jettanong Klaewsongkram
P144 HLA-B*15:02 alleles and lamotrigine-induced cutaneous adverse drug reactions in Thai
Chonlaphat Sukasem, N. Koomdee, T. Jantararoungtong, S. Santon, A. Puangpetch, U. Intusoma, W. Tassaneeyakul, V. Theeramoke
P145 HLA-B*38:01 and HLA-A*24:02 allele frequencies in Spanish patients with lamotrigine-induced SCARs
Teresa Bellón, Elena Ramirez, Alberto Manuel Borobia, Hoi Tong, Jose Luis Castañer, Francisco José De Abajo
P146 Overrepresentation of a class II HLA haplotype in severe hypersensitivity type I reactions to carboplatin
Violeta Régnier Galvao, Rebecca Pavlos, Elizabeth Mckinnon, Kristina Williams, Alicia Beeghly-Fadiel, Alec Redwood, Elizabeth Phillips, Mariana Castells
Poster walk 17: in vivo diagnosis + sIgE (P147–P154)
P147 Absence of specific Ig-e against beta-lactams 9 months after an allergic reaction to amoxicillin-clavulanic acid
Elisa Boni, Marina Russello, Marina Mauro
P148 Drug provocation tests in suspected opioid allergy
Kok Loong Ue, Krzysztof Rutkowski
P149 Improvement to the specific IgE cut-off in the assess of β-lactamic allergy
Victor Soriano Gomis, Jorge Frances Ferre, Angel Esteban Rodriguez, Vicente Cantó Reig, Javier Fernandez Sanchez
P150 Initial false negative specific IgE to gelatin in a patient with gelatin-induced anaphylaxis
Christine Breynaert, Erna Van Hoeyveld, Rik Schrijvers
P151 Inmediate reactions to beta-lactam antibiotics: pattern of skin test response over the time
Jose Julio Laguna Martinez, Rosario Gonzalez Mendiola, Javier Dionicio Elera, Cosmin Boteanu, Aranzazu Jimenez Blanco, Marta Del Pozo, Raquel Fuentes Irigoyen
P152 New fluorescent dendrimeric antigens for the evaluation of dendritic cell maturation as a test to detect allergy reactions to amoxicillin
Daniel Collado, Yolanda Vida, Francisco Najera, Ezequiel Perez-Inestrosa, Pablo Mesa-Antunez, Cristobalina Mayorga, María José Torres, Miguel Blanca
P153 Positive skin test or positive specific IgE to penicillin does not predict penicillin allergy
Line K. Tannert, Charlotte G. Mortz, Per Stahl Skov, Carsten Bindslev-Jensen
P154 Significance of skin testing and in vitro-analysis of neuromuscular blocking agents in diagnosis of perioperative drug hypersensitivity: evaluation of a negative control population
Wolfgang Pfützner, Hannah Dörnbach, Johanna Visse, Michele Rauber, Christian Möbs
Poster walk 18: in vitro/ex vivo (P155–P158, P160–P164)
P155 Diagnostic value of the lymphocyte toxicity assay (LTA) and the in vitro platelet toxicity assay (IPTA) for β-lactam allergy
Abdelbaset A. Elzagallaai, Lindsey Chow, Awatif M. Abuzgaia, Michael J. Rieder
P156 Enzyme linked immunospot assay used in the diagnosis of severe cutaneous adverse reactions to antimicrobials
Alec Redwood, Jason Trubiano, Rebecca Pavlos, Emily Woolnough, Kaija Stautins, Christina Cheng, Elizabeth Phillips
P157 Evaluation of in vitro diagnostic methods for identifying the culprit drugs in drug hypersensitivity
Kenichi Kato, Hiroaki Azukizawa, Takaaki Hanafusa, Ichiro Katayama
P158 Ex-vivo expanded skin-infiltrating T cells from severe drug eruptions are reactive with causative drugs: a possible novel method for determination of causative drugs
Toshiharu Fujiyama, Hideo Hashizume, Takatsune Umayahara, Taisuke Ito, Yoshiki Tokura
P160 In vitro release of IL-2, IL-5 and IL-13 in diagnosis of patients with delayed-type nickel hypersensitivity
Mira Silar, Mihaela Zidarn, Helena Rupnik, Peter Korosec
P161 Single cell analysis of drug responsive T cells; identification of candidate drug reactive T cell receptors in abacavir and carbamazepine hypersensitivity
Alec James Redwood, Kaija Strautins, Katie White, Abha Chopra, Katherine Konvinse, Shay Leary, Rebecca Pavlos, Simon Mallal, Elizabeth Phillips
P162 Specificity and sensitivity of LTT in DRESS: analysis of agreement with the Spanish pharmacovigilance system probability algorithm
Rosario Cabañas, Elena Ramirez, Ana María Fiandor, Teresa Bellón
P163 The role of interleukin-22 in β-lactam hypersensitivity
Andrew Sullivan, Paul Whitaker, Daniel Peckham, B. Kevin Park, Dean J. Naisbitt
P164 Vancomycin-specific T cell responses and teicoplanin cross-reactivity
Wei Yann Haw, Marta E. Polak, Carolann Mcguire, Michael R. Ardern-Jones
Poster walk 19: BAT and biomarkers (P165–P173)
P165 A combination of early biomarkers useful for the prediction of severe ADRs
Yumi Aoyama, Tetsuo Shiohara
P166 Basophil activation test in the diagnostic approach of reactions during general anaesthesia
Ana Moreira, Susana Cadinha, Patrícia Barreira, Ana Castro Neves, Daniela Malheiro, Sara Correia, J. P. Moreira Da Silva
P167 IL-10 can be related to successful desensitization
Asli Gelincik, Semra Demir, Fatma Sen, Hamza Ugur Bozbey, Muge Olgac, Derya Unal, Raif Coskun, Bahauddin Colakoglu, Suna Buyuozturk, Esin Çatin-Aktas, Gunnur Deniz
P168 Immediate reactions to proton pump inhibitors: value of basophil activation test
Maria Salas, Jose Julio Laguna, Esther Barrionuevo, J. Dionicio, Tahia Fernandez, R. Gonzalez-Mendiola, I. Olazabal, Maria Dolores Ruiz, Miguel Blanca, Cristobalina Mayorga, Maria José Torres
P169 Improvement of the elevated tryptase criterion to discriminate IgE from non-IgE mediated allergic reactions
Gabriel Gastaminza, Alberto Lafuente, Carmen D’Amelio, Amalia Bernad, Olga Vega, Roselle Catherine Madamba, M. Jose Goikoetxea, Marta Ferrer, Jorge Núñez
P170 Low expression of Tim-3 could serve as a biomarker for control and diagnose maculopapular exanthema induced by drugs
Tahia Diana Fernández, Inmaculada Doña, Francisca Palomares, Rubén Fernández, Maria Salas, Esther Barrionuevo, Maria Isabel Sanchez, Miguel Blanca, Maria José Torres, Cristobalina Mayorga
P171 Role of basophil activation test using two different activation markers for the diagnosis of allergy to fluoroquinolones
Esther Barrionuevo, Tahía Fernandez, Arturo Ruiz, Adriana Ariza, Maria Salas, Inmaculada Doña, Ana Molina, Miguel Blanca, Maria Jose Torres, Cristobalina Mayorga
P172 The importance of basophil activation test in anaphylaxis due to celecoxib
Amalia Bernad Alonso, Carmen D’Amelio Garófalo, Olga Vega Matute, Marta Ferrer Puga, María José Goikoetxea Lapresa, Roselle Catherine Yu Madamba, Gabriel Gastaminza Lasarte
P173 The role of basophil activation test in the diagnosis of immediate type drug hypersensitivity to betalactam antibiotics
Antonia Thinnes, Hans F. Merk, Jens Malte Baron, Martin Leverkus, Galina Balakirski
Poster walk 20: TCR recognition, cellular (P174–P183)
P174 Characterisation of the effect of co-inhibitory signalling on the activation of drug-derived antigen-specific T-cells
Andrew Gibson, Monday Ogese, Lee Faulkner, B. Kevin Park, Dean J. Naisbitt
P175 Characterization of drug hapten-specific T cell responses in piperacillin hypersensitive patients
Zaid Al-Attar, Fiazia Yaseen, Xiaoli Meng, Rozalind Jenkins, Paul Whitaker, Daniel Peckham, Lee Faulkner, John Farrel, Kevin Park, Dean Naisbitt
P176 Characterization of the response of T-cells to telaprevir and its metabolite in normal volunteers
Zaid Al-Attar, Khetam Alhilali, Yanni Xue, John Farrell, Lee Faulkner, Kevin Park, Dean Naisbitt
P177 Characterization of the T cell receptor signatures of drug-responsive T cells
Patricia Illing, Nicole Mifsud, Heidi Fettke, Jeffrey Lai, Rebecca Ho, Patrick Kwan, Anthony Purcell
P178 Defining the signals between hepatocytes and immune cells in idiosyncratic drug-induced liver injury (DILI)
Monday O. Ogese, Lee Faulkner, B. Kevin Park, Catherine Betts, Dean J. Naisbitt
P179 Development of novel chemicals that do not bind to HLA-B*57:01 or activate CD8 + T-cells through modification of the 6-amino cyclopropyl group of abacavir
Paul Thomson, John Farrell, Mohammad Alhaidari, Neill Berry, Paul M. O’Neill, B. Kevin Park, Dean J. Naisbitt
P180 Generation and characterization of dapsone- and nitroso-dapsone-specific T-cell clones using lymphocytes from healthy volunteers
Abdulaziz Alzahrani, Monday O. Ogese, John Farrell, Lee Faulkner, Andrew Gibson, Arun Tailor, B. Kevin Park, Dean J. Naisbitt
P181 Identification of benzylpenicillin-hapten peptides responsible for naïve T-cell activation and immunization of allergic patients to penicillin
Marie Eliane Azoury, Lucia Fili, Rami Bechara, Noémie Scornet, Cathy Nhim, Richard Weaver, Nancy Claude, Delphine Joseph, Bernard Maillere, Paola Parronchi, Marc Pallardy
P182 Massive expansion of clonotypic and polycytotoxic CD8+ T cells in toxic epidermal necrolysis
Axel Patrice Villani, Aurore Rozières, Benoît Bensaïd, Mathilde Tardieu, Floriane Albert, Virginie Mutez, Tugba Baysal, Marc Pallardy, Janet Maryanski, Jean-François Nicolas, Osami Kanagawa, Marc Vocanson
P183 Pharmaco-immunological synapse of HLA-drug-TCR in SCAR
Shuen-Iu Hung
Poster walk 21: new in vitro methods, haptens, etc. (P184–P194)
P184 Amoxicillin-clavulanate forms distinct multiple haptenic structures on human serum albumin in patients
Xiaoli Meng, Arun Tailor, Caroline J. Harrison, Rosalind E. Jenkins, Paul Whitaker, Neil S. French, Dean J. Naisbitt, B. Kevin Park
P185 Dendrimeric antigens for studying the influence of penicillin determinants orientation on IgE recognition
Maria Isabel Montañez, Cristobalina Mayorga, Francisco Najera, Adriana Ariza, Tahia D. Fernandez, Maria Salas, Angela Martin-Serrano, Miguel Blanca, Ezequiel Perez-Inestrosa, Maria Jose Torres
P186 Dendrimeric antigens on solid supports: designed materials for IgE quantification
Yolanda Vida, Maria Isabel Montañez, Noemi Molina, Daniel Collado, Francisco Najera, Adriana Ariza, Maria Jose Torres, Cristobalina Mayorga, Ezequiel Perez-Inestrosa
P187 Development of a screening assay for drug hypersensitivity using naïve T cells from donors with seven different HLA class I risk alleles
Lee Faulkner, Sally Wood, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park
P188 Different patterns of recognition of structures derived from amoxicillin by IgE antibodies from patients with immediate hypersensitivity reactions to betalactams
Adriana Ariza, Cristobalina Mayorga, María Isabel Montañez, María Salas, Inmaculada Doña, Ángela Martín-Serrano, Ezequiel Pérez-Inestrosa, Dolores Pérez-Sala, Miguel Blanca, Antonio E. Guzmán, María José Torres
P189 High-resolution typing of HLA polymorphism and T-cell receptor repertoire for severe adverse drug reactions based on the cost-effective next-generation sequencing approaches
Tai-Ming Ko, Yuan-Tsong Chen, Jer-Yuarn Wu
P190 Identification and fate of intracellular proteins haptenated by amoxicillin
Francisco J. Sánchez-Gómez, Juan M. González-Morena, Yolanda Vida, Ezequiel Pérez-Inestrosa, Miguel Blanca, María J. Torres, Dolores Pérez-Sala
P191 In vitro detection of terbinafine protein adducts
Arun Tailor, Toru Usui, Yanni Xue, Xiaoli Meng, Dean J. Naisbitt, B. Kevin Park
P192 MicroRNAs dysregulation in PBMCs from drug hypersensitivity patients during drug challenge in vitro
Alejandra Monroy Arreola, Jesus Agustin Badillo Corona, Silvia Mendez Flores, Judith Dominguez Cherit, Dean J. Naisbitt, Noe Valentin Duran Figueroa, Jose Luis Castrejon Flores
P193 NSAIDs-exacerbated cutaneous disease: high throughput gene expression profiling
José Antonio Cornejo-García, James Perkins, Natalia Blanca-López, Diana Pérez-Alzate, Raquel Jurado-Escobar, Inmaculada Doña, Gador Bogas, María J. Torres, Gabriela Canto, Miguel Blanca
P194 Utility of skin tests in non-immediate reactions to amoxicillin
Luis Mario Tubella Marti, Fernando Pineda De La Losa, Francisca Arribas Poves, Jaime Tubella Lopez, Teodora Lopez Santiago
doi:10.1186/s13601-016-0122-y
PMCID: PMC5009521
3.  7th drug hypersensitivity meeting: part one 
Carr, Daniel F. | Chung, Wen-Hung | Jenkiins, Rosalind E. | Chaponda, Mas | Nwikue, Gospel | Cornejo Castro, Elena M. | Antoine, Daniel J. | Pirmohamed, Munir | Wuillemin, Natascha | Dina, Dolores | Eriksson, Klara K. | Yerly, Daniel | Pavlos, Rebecca | Mckinnin, Elizabeth | Ostrov, David | Peters, Bjoern | Buus, Soren | Koelle, David | Chopra, Abha | Rive, Craig | Redwood, Alec | Restrepo, Susana | Bracey, Austin | Yuan, Jing | Gaudieri, Silvana | Carrington, Mary | Haas, David | Mallal, Simon | Phillips, Elizabeth | De Boer, Douwe | Menheere, Paul | Nieuwhof, Chris | Bons, Judith | Jonsson, Friederike | De Chaisemartin, Luc | Granger, Vanessa | Gillis, Caitlin | Gouel, Aurelie | Neukirch, Catherine | Dib, Fadia | Nicaise, Pascale Roland | Longrois, Dan | Tubach, Florence | Martin, Sylvie | Bruhns, Pierre | Chen, Kai-Lung | Liao, Shu-Ling | Sheen, Yi-Shuan | Cho, Yung-Tsu | Yang, Che-Wen | Liau, Jau-Yu | Chu, Chia-Yu | Aguiar, Rita | Lopes, Anabela | Fernandes, Natália | Viegas, Leonor | Pereira-Barbosa, M. A. | Bünter, Antonia | Gupta, Nisha | Petkovic, Tatjana Pecaric | Wirth, Nicole | Pichler, Werner J. | Hausmann, Oliver | Yazicioglu, Mehtap | Ozdemir, Pinar G. | Ciplak, Gokce | Kaya, Ozkan | Cooke, Peter John | Mota, Inês | Gaspar, Ângela | Benito-Garcia, Filipe | Chambel, Marta | Morais-Almeida, Mário | Marques, Luis | Alcoceba, Eva | Lara, Silvia | Carneiro-Leão, Leonor | Botelho, Carmen | Dias-Castro, Eunice | Cernadas, Josefina R. | Nicholls, Katherine | Lay, William | Smith, Olivia | Collins, Christine | Unglik, Gary | Spriggs, Kymble | Auyeung, Priscilla | McComish, Jeremy | Douglass, Jo A. | Peter, Jonny G. | Potter, Paul | Carolino, Fabrícia | De Castro, Eunice Dias | Moreira, Ana Sofia | Abreu, Carmo | Gomes, Eva | Cardoso, Bárbara Kong | Tomaz, Elza | Correia, Sara | Inácio, Filipe | Arnold, Annabelle | Bear, Natasha | Rueter, Kristina | Gong, Grace | O’Sullivan, Michael | Muthusamy, Saravanan | Noble, Valerie | Lucas, Michaela | Buterleviciute, Neringa | Rudzeviciene, Odilija | Abreu, Carmo | May, Sara | Pongdee, Thanai | Park, Miguel | Griguola, Linas | Vinikovas, Arturas | Kašinskaite, Simona | Kvedariene, Violeta | Aktas, Ayse | Rahman, Suheyla | Elbi, Huseyin | Ozyurt, Beyhan Cengiz | Cavkaytar, Ozlem | Karaatmaca, Betul | Cetinkaya, Pinar Gur | Esenboga, Saliha | Sahiner, Umit M. | Sekerel, Bulent E. | Soyer, Ozge | Zubrinich, Celia | Tong, Bianca | Patel, Mittal | Giles, Michelle | O’Hehir, Robyn | Puy, Robert | Amaral, Luís | Demir, Semra | Gelincik, Asli | Olgac, Muge | Caskun, Raif | Unal, Derya | Colakoglu, Bahauddin | Buyukozturk, Suna | Matute, Olga Vega | Bernad, Amalia | Gastaminza, Gabriel | Madamba, Roselle | Lacasa, Carlos | Goikoetxea, M. J. | D’Amelio, Carmen | Rifón, Jose | Martínez, Nicolas | Ferrer, Marta | Ribeiro, Carmelita | Faria, Emília | Frutuoso, Cristina | Barros, Anabela | Lebre, Rosário | Pego, Alice | Bom, Ana Todo | Ensina, Luis Felipe | Aranda, Carolina | Nunes, Ines Camelo | Martins, Ana Maria | Solé, Dirceu | Bavbek, Sevim | Kendirlinan, Resat | Çerçi, Pamir | Tutluer, Seda | Soyyigit, Sadan | Sözener, Zeynep Çelebi | Aydin, Ömür | Gümüsburun, Reyhan | Almeida, Marta | Sai, Kimie | Imatoh, Takuya | Nakamura, Ryosuke | Fukazawa, Chisato | Hinomura, Yasushi | Saito, Yoshiro | Sousa-Pinto, Bernardo | Correia, Cláudia | Gomes, Lídia | Gil-Mata, Sara | Araújo, Luís | Delgado, Luís | Sai, Kimie | Okamoto-Uchida, Yoshimi | Kajinami, Koji | Matsunaga, Kayoko | Aihara, Michiko | Wang, Chuang-Wei | Su, Shih-Chi | Hung, Shuen-Iu | Ho, Hsin-Chun | Yang, Chih-Hsun | Paulmann, Maren | Dunant, Ariane | Mockenhaupt, Maja | Sekula, Peggy | Schumacher, Martin | Kardaun, Sylvia | Naldi, Luigi | Bellón, Teresa | Creamer, Daniel | Haddad, Cynthia | Sassolas, Bruno | Lebrun-Vignes, Bénédicte | Valeyrie-Allanore, Laurence | Roujeau, Jean-Claude | Paulmann, Maren | Kremmler, Carmen | Mockenhaupt, Maja | Dodiuk-Gad, Roni P. | Olteanu, Cristina | Feinstein, Anthony | Hashimoto, Rena | Alhusayen, Raed | Whyte-Croasdaile, Sonia | Finkelstein, Yaron | Burnett, Marjorie | Sade, Shachar | Cartotto, Robert | Jeschke, Marc | Shear, Neil H. | Takamura, Naoko | Yamane, Yumiko | Matsukura, Setsuko | Nakamura, Kazuko | Watanabe, Yuko | Yamaguchi, Yukie | Kambara, Takeshi | Ikezawa, Zenro | Aihara, Michiko | Hashimoto, Rena | Chew, Hall | Burnett, Marjorie | Jeschke, Marc | Knezevic, Brittany | Ionmhain, Una Nic | Barraclough, Allison | Anstey, Matthew | Usui, Toru | Meng, Xiaoli | Farrell, John | Whitaker, Paul | Watson, John | French, Neil | Park, Kevin | Naisbitt, Dean | Neves, Ana Castro | Cadinha, Susana | Moreira, Ana | Da Silva, J. P. Moreira | Drvar, Daniela Ledic | Gulin, Sandra Jerkovic | Hadzavdic, Suzana Ljubojevic | Ceovic, Romana | De Francisco, Ana Montoro | De Vicente Jiménez, Talía | Luque, Amelia García | David, Natalia Rosado | Galván, José Mª Mateos | Darlenski, Razvigor | Gulin, Dario | Sikic, Jozica | Habek, Jasna Cerkez | Galic, Edvard | Specht, Philip | Staab, Doris | Mayer, Beate | Roehmel, Jobst | Solovan, Caius | Chiriac, Anca | Djurinec, Paola | Kostovic, Kresimir | Bradamante, Mirna | Almeida, Jose Pedro | Caiado, Joana | Pedro, Elisa | Da Silva, Pedro Canas | Barbosa, Manuel Pereira | Bogas, Gador | Blanca-López, Natalia | Pérez-Alzate, Diana | Doña, Inmaculada | Agúndez, José Augusto | García-Martín, Elena | Cornejo-García, José Antonio | Mayorga, Cristobalina | Torres, María José | Canto, Maria Gabriela | Blanca, Miguel | Aksakal, Sengül | Sin, Aytül Zerrin | Koç, Zeynep Peker | Günsen, Fatma Düsünür | Ardeniz, Ömür | Gökmen, Emine Nihal Mete | Gülbahar, Okan | Kokuludag, Ali | Pérez-Sánchez, Natalia | Salas, María | Salas, Maria | Gomez, Francisca | Barrionuevo, Esther | Andreu, Inmaculada | Miranda, Miguel Ángel | Didžiokaite, Gabija | Gaidej, Olesia | Kašinskaite, Simona | Garcimartin, Maria Isabel | Somoza, Maria Luisa | Bojas, Gador | Cornejo-Garcia, Jose Antonio | Perez, Francisco Javier Ruano | Miranda, Miguel Angel | Jerschow, Elina | Pelletier, Teresa | Ren, Zhen | Hudes, Golda | Sanak, Marek | Morales, Esperanza | Schuster, Victor | Spivack, Simon D | Rosenstreich, David | Erzen, Renato | Silar, Mira | Bajrovic, Nissera | Rijavec, Matija | Zidarn, Mihaela | Korosec, Peter | Castro, Eunice | Al-Ahmad, Mona | Rodriguez, Tito | Azevedo, João Pedro | Tavares, Beatriz | Regateiro, Frederico | Todo-Bom, Ana | Miranda, Pablo Andrés | De La Cruz Hoyos, Bautista | Abuzeid, Waleed | Akbar, Nadeem | Gibber, Marc | Fried, Marvin | Han, Weiguo | Keskin, Taha | Tamayev, Robert | Spivack, Simon D. | Rosenstreich, David | Jerschow, Elina | Boni, Elisa | Russello, Marina | Mauro, Marina | Neto, Marta Ferreira | Brosseron, Lise | Malheiro, Daniela | Barreira, Patrícia | Sprigg, Dustin | Trevenen, Michelle | Seet, Jason | Trubiano, Jason | Smith, William | Jeelall, Yogesh | Vale, Sandra | Loh, Richard | Mclean-Tooke, Andrew | Müller, Sabine | Amstutz, Ursula | Jörg, Lukas | Yawalkar, Nikhil | Krähenbühl, Stephan | Leblanc, Ana | Ribeiro, Laura | Vega, Arantza | Rivas, Raquel Gutierrez | Alonso, Ana | Beitia, Juan Maria | Mateo, Belén | Cárdenas, Remedios | Garcia-Dominguez, Juan Jesus | Pavlos, Rebecca | Strautins, Kaija | James, Ian | Mallal, Simon | Redwood, Alec | Aguiar, Rita | Lopes, Anabela | Neves, Ana | Do Céu Machado, Maria | Dalgiç, Ceyda Tunakan | Gökmen, Emine Nihal Mete | Bulut, Gökten | Ardeniz, Fatma Ömür | Gülbahar, Okan | Sin, Aytül Zerrin | Hsu, Shao-Hsuan | Yang, Che-Wen | Ye, Young-Min | Hur, Gyu-Young | Park, Hae-Sim | Kim, Seung-Hyun | Ali, Syed | Hollingsworth, Peter N. | Mclean-Tooke, Andrew P. C. | Chadly, Zohra | Fredj, Nadia Ben | Aouam, Karim | Romdhane, Haifa Ben | Boughattas, Naceur A. | Chaabane, Amel | Salazar, Marina Lluncor | Pola, Beatriz | Fiandor, Ana | Ramírez, Elena | Ortega, Javier Domínguez | Quirce, Santiago | Cabañas, Rosario | Baynova, Krasimira | Labella, Marina | Prados, Manuel | Ramonaite, Agne | Bajoriuniene, Ieva | Sitkauskiene, Brigita | Sakalauskas, Raimundas | Kwon, Jae-Woo | Park, Shinyoung | Silva, Diana | Leão, Leonor Carneiro | Castro, Eunice | Garcimartin, Maria | De La Torre, Maria Vazquez | Pérez, Francisco Javier Ruano | Haroun, Elisa | Diez, Gabriela Canto | Ónodi-Nagy, Katinka | Kinyó, Ágnes | Kemény, Lajos | Bata-Csörgo, Zsuzsanna | Pita, Joana Sofia | Fernandes, Rosa Anita | Moura, Ana | Sousa, Nuno | Loureiro, Carlos | Pfützner, Wolfgang | Marrouche, Nadine | Grattan, Clive | Chen, Yu-En | Chen, Chun-Bing | Hsiao, Yu-Ping | Garcimartin, Maria Isabel | Ruano, Francisco Javier
Table of contents
Oral Abstracts
O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN
Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed
O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?
Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly
O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity
Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips
O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE?
Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons
O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study
Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group
O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases
Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu
Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09)
P1 Anaphylactic reactions during anaesthesia and the perioperative period
Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa
P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine?
Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann
P3 Cefotaxime-induced severe anaphylaxis in a neonate
Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya
P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine
Peter John Cooke
P5 Drug-induced anaphylaxis: five-year single-center survey
Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida
P6 Intraoperative severe anaphylactic reaction due to patent blue v dye
Luis Marques, Eva Alcoceba, Silvia Lara
P7 Kounis syndrome in the setting of anaphylaxis to diclofenac
Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas
P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital
Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass
P9 Recurrent peri-operative anaphylaxis: a perfect storm
Jonny G. Peter, Paul Potter
Poster Walk 2: DH regions and patient groups (P10–P19)
P10 A rare presentation of amoxicillin allergy in a young child
Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas
P11 Adverse drug reactions in children: antibiotics or virus?
Ana Sofia Moreira, Carmo Abreu, Eva Gomes
P12 Allergic reactions in invasive medical procedures
Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio
P13 Antibiotic allergy in children: room for improvement
Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas
P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation
Neringa Buterleviciute, Odilija Rudzeviciene
P15 Nonimmediate cutaneous drug reactions in children: are skin tests required?
Ana Sofia Moreira, Carmo Abreu, Eva Gomes
P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies
Sara May, Thanai Pongdee, Miguel Park
P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos
Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene
P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey
Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt
P19 Severe drug hypersensitivity reactions in pediatric age
Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer
Poster Walk 3: Desensitisation (P20–P28)
P20 A protocol for desensitisation to valaciclovir
Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy
P21 A rare case of desensitization to modafinil
Josefina Cernadas, Luís Amaral, Fabrícia Carolino
P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs
Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk
P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report
Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer
P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years
Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom
P25 Filgrastim anaphylaxis: a successful desensitization protocol
Luis Amaral, Josefina Cernadas
P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient
Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé
P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals
Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun
P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction
Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida
Poster Walk 4: SJS (P29–P38)
P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database
Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito
P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations
Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado
P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports
Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation
Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung
P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study
Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau
P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis
Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt
P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis
Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear
P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome
Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara
P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis
Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear
P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report
Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey
Poster Walk 5: Other organs/unexpected immune reactions (P39–P47)
P39 A case report of patient with anti-tuberculosis drug-related severe liver failure
Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt
P40 Acute interstitial nephritis induced by ibuprofen
Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva
P41 Cetuximab induced acneiform rash—two case reports
Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic
P42 Enteropathy associated with losartan
Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván
P43 Granuloma annulare after therapy with canakinumab
Razvigor Darlenski
P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report
Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic
P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis
Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel
P46 Progesterone triggered pemphigus foliaceus: case report
Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac
P47 Ramipril: triggered generalized pustular psoriasis
Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic
Poster Walk 6: NSAIDs (P48–P56)
P48 Aspirin desensitization in cardiovascular disease—Portuguese experience
Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa
P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA
Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca
P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity
Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag
P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA
Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto
P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases
Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca
P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs
Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene
P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses
Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca
P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA
Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto
P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease
Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich
Poster Walk 7: NSAID 2 (P57–P65)
P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations
Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec
P58 Anaphylaxis to diclofenac: what about the underlying mechanism?
Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas
P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs?
Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas
P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty
Mona Al-Ahmad, Tito Rodriguez
P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients
João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom
P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia
Pablo Andrés Miranda, Bautista De La Cruz Hoyos
P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease
Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow
P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema
Elisa Boni, Marina Russello, Marina Mauro
P65 Selective hypersensitivity reactions to ibuprofen—seven years experience
Marta Ferreira Neto
Poster Walk 8: Epidemiological methods (P66–P72)
P66 Allopurinol hypersensitivity: a 7-year review
Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva
P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia
Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas
P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015
Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear
P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening
Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl
P70 Patients with suspected drug allergy: a specific psychological profile?
Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas
P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability
Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez
P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity
Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips
Poster Walk 9: DRESS/AGEP (P73–P81)
P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid
Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa
P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease
Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin
P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions
Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu
P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome
Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim
P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation
Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke
P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug
Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane
P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose
Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas
P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report
Krasimira Baynova, Marina Labella, Manuel Prados
P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection
Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas
Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91)
P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test
Jae-Woo Kwon, Shinyoung Park
P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit
Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas
P84 Allergy to heparins
Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez
P85 Allopurinol-induced adverse drug reactions
Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo
P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review
Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom
P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure
Wolfgang Pfützner
P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox?
Nadine Marrouche, Clive Grattan
P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians
Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-Ping Hsiao, Chia-Yu Chu
P90 Diagnosis of allergic reactions to eye drops
Maria Vazquez De La Torre, Natalia Blanca-Lopez, Diana Perez-Alzate, Maria Isabel Garcimartin, Francisco Javier Ruano, Maria Luisa Somoza, Elisa Haroun, Gabriela Canto
P91 Diagnostic approach in suspected hypersensitivity reactions to corticosteroids
Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas
doi:10.1186/s13601-016-0121-z
PMCID: PMC5009634
4.  Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma 
Toxicological Sciences  2015;146(1):192-201.
Diisocyanates, reactive chemicals used to produce polyurethane products, are the most common causes of occupational asthma. The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. Genome-wide single nucleotide polymorphism (SNP) genotyping was performed in 74 diisocyanate-exposed workers with DA and 824 healthy controls using Omni-2.5 and Omni-5 SNP microarrays. We identified 11 SNPs that exceeded genome-wide significance; the strongest association was for the rs12913832 SNP located on chromosome 15, which has been mapped to the HERC2 gene (p = 6.94 × 10−14). Strong associations were also found for SNPs near the ODZ3 and CDH17 genes on chromosomes 4 and 8 (rs908084, p = 8.59 × 10−9 and rs2514805, p = 1.22 × 10−8, respectively). We also prioritized 38 SNPs with suggestive genome-wide significance (p < 1 × 10−6). Among them, 17 SNPs map to the PITPNC1, ACMSD, ZBTB16, ODZ3, and CDH17 gene loci. Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. This study identified SNPs mapping to the HERC2, CDH17, and ODZ3 genes as potential susceptibility loci for DA. Pathway analysis indicated that these genes are associated with antigen processing and presentation, and other immune pathways. Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. These results provide new insights into the genetic architecture of DA and serve as a basis for future functional and mechanistic studies.
doi:10.1093/toxsci/kfv084
PMCID: PMC4560052  PMID: 25918132
asthma; diisocyanate; genetic polymorphism; genome-wide association study
5.  Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma 
Journal of immunotoxicology  2015;13(1):119-126.
Diisocyanates are the most common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants in inflammatory response genes (TNFα, IL1α, IL1β, IL1RN, IL10, TGFB1, ADAM33, ALOX-5, PTGS1, PTGS2 and NAG-1/GDF15) are associated with increased susceptibility to diisocyanate asthma (DA). These genes were selected based on their role in asthmatic inflammatory processes and previously reported associations with asthma phenotypes. The main study population consisted of 237 Caucasian French Canadians from among a larger sample of 280 diisocyanate-exposed workers in two groups: workers with specific inhalation challenge (SIC) confirmed DA (DA+, n = 95) and asymptomatic exposed workers (AW, n = 142). Genotyping was performed on genomic DNA, using a 5′ nuclease PCR assay. After adjusting for potentially confounding variables of age, smoking status and duration of exposure, the PTGS1 rs5788 and TGFB1 rs1800469 single nucleotide polymorphisms (SNP) showed a protective effect under a dominant model (OR = 0.38; 95% CI = 0.17, 0.89 and OR = 0.38; 95% CI = 0.18, 0.74 respectively) while the TNFα rs1800629 SNP was associated with an increased risk of DA (OR = 2.08; 95% CI = 1.03, 4.17). Additionally, the PTGS2 rs20417 variant showed an association with increased risk of DA in a recessive genetic model (OR = 6.40; 95% CI = 1.06, 38.75).These results suggest that genetic variations in TNFα, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility.
doi:10.3109/1547691X.2015.1017061
PMCID: PMC4814713  PMID: 25721048
Cytokine; diisocyanates; inflammation; occupational asthma; single nucleotide polymorphism (SNP)
6.  Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma 
Objective
To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).
Methods
The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.
Results
The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).
Conclusion
These results suggest that genetic variations within HLA genes play a role in DA risk.
doi:10.1097/JOM.0000000000000138
PMCID: PMC4572490  PMID: 24709764
9.  SOCS3 Silencing Attenuates Eosinophil Functions in Asthma Patients 
Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high levels of suppressor of cytokine signaling 3 (SOCS3). In this article, SOCS3 gene silencing in eosinophils from asthmatics has been carried out to achieve a better understanding of the suppressor function in eosinophils. SOCS3 siRNA treatment drastically reduced SOCS3 expression in eosinophils, leading to an inhibition of the regulatory transcription factors GATA-3 and FoxP3, also interleukin (IL)-10; in turn, an increased STAT3 phosphorilation was observed. Moreover, SOCS3 abrogation in eosinophils produced impaired migration, adhesion and degranulation. Therefore, SOCS3 might be regarded as an important regulator implicated in eosinophil mobilization from the bone marrow to the lungs during the asthmatic process.
doi:10.3390/ijms16035434
PMCID: PMC4394485  PMID: 25764157
short interfering RNAs (siRNAs); SOCS3; eosinophils; asthma
10.  Occupational Rhinoconjunctivitis due to Maize in a Snack Processor: A Cross-Reactivity Study Between Lipid Transfer Proteins From Different Cereals and Peach 
We report the case of a snack processor who developed occupational rhinoconjunctivitis due to maize brand exposure during the extrusion process, and who experienced abdominal pain upon drinking beer. The allergens implicated and the cross-reactivity between non-specific lipid transfer proteins (LTPs) from different cereals and peach were investigated. Skin prick tests and specific IgE to cereal flours, pulmonary functions tests and specific conjunctival and inhalation challenges to maize extract were performed. In vitro studies included IgE immunoblotting and ELISA inhibition assays. Skin prick tests with maize flour, maize brand and wheat flour extracts were positive, whereas serum specific IgE was positive only to maize flour. Specific inhalation challenge (SIC) to maize flour did not elicit an asthmatic reaction; however, conjunctival challenge test with the same extract was positive. Patient's serum recognized IgE-binding bands in the maize and beer extracts corresponding to LTPs. In the ELISA inhibition assays, a significant degree of allergenic cross-reactivity was found between maize and beer LTPs, whereas no cross-reactivity was observed between maize LTP and wheat and peach LTPs.
doi:10.4168/aair.2014.6.5.470
PMCID: PMC4161691  PMID: 25229007
Occupational rhinitis; non-specific lipid transfer proteins; specific IgE; maize
14.  CTNNA3 (α-Catenin) Gene Variants Are Associated With Diisocyanate Asthma: A Replication Study in a Caucasian Worker Population 
Toxicological Sciences  2012;131(1):242-246.
Recently, a genome-wide association study (GWAS) conducted in Korean subjects identified four CTNNA3 (alpha-T catenin) single nucleotide polymorphisms (SNPs) (rs10762058, rs7088181, rs1786929, and rs4378283) associated with diisocyanate-induced occupational asthma (DA). The CTNNA3 gene codes for a cadherin involved in formation of stretch-resistant cell-cell adhesions. We conducted a candidate gene association study to replicate these findings in Caucasian workers. Genotyping was performed on DNA using a 5′ nuclease PCR assay collected from 410 diisocyanate-exposed and predominantly Canadian workers including 132 workers with DA confirmed by a specific inhalation challenge (DA+); 131 symptomatic workers in whom DA was excluded by a negative challenge (DA−); and 147 hexamethylene diisocyanate–exposed asymptomatic workers (AWs). As in the Korean study, highly linked CTNNA3 rs7088181 and rs10762058 SNPs (but not rs4378283 and rs1786929) were significantly associated with DA+ when compared with AWs but not in comparison with DA− workers (p ≤ 0.05). After adjusting for potentially confounding variables of age, smoking status, and duration of exposure, minor allele homozygotes of rs7088181 and rs10762058 SNPs were at increased risk for DA compared with AWs (OR = 9.05 [95% CI: 1.69, 48.54] and OR = 6.82 [95% CI: 1.65, 28.24], respectively). In conclusion, we replicated results from the only reported GWAS study of DA demonstrating an association between two closely linked CTNNA3 gene SNPs and DA. These findings lend further support to the clinical relevance of these genotypes in predicting susceptibility to DA and the potential importance of catenins in the disease process.
doi:10.1093/toxsci/kfs272
PMCID: PMC3537126  PMID: 22977168
diisocyanate asthma; CTNNA3; alpha-T catenin; occupational asthma
15.  Diagnosis and Management of Grain-Induced Asthma 
Grain-induced asthma is a frequent occupational allergic disease mainly caused by inhalation of cereal flour or powder. The main professions affected are bakers, confectioners, pastry factory workers, millers, farmers, and cereal handlers. This disorder is usually due to an IgE-mediated allergic response to inhalation of cereal flour proteins. The major causative allergens of grain-related asthma are proteins derived from wheat, rye and barley flour, although baking additives, such as fungal α-amylase are also important. This review deals with the current diagnosis and treatment of grain-induced asthma, emphasizing the role of cereal allergens as molecular tools to enhance diagnosis and management of this disorder. Asthma-like symptoms caused by endotoxin exposure among grain workers are beyond the scope of this review. Progress is being made in the characterization of grain and bakery allergens, particularly cereal-derived allergens, as well as in the standardization of allergy tests. Salt-soluble proteins (albumins plus globulins), particularly members of the α-amylase/trypsin inhibitor family, thioredoxins, peroxidase, lipid transfer protein and other soluble enzymes show the strongest IgE reactivities in wheat flour. In addition, prolamins (not extractable by salt solutions) have also been claimed as potential allergens. However, the large variability of IgE-binding patterns of cereal proteins among patients with grain-induced asthma, together with the great differences in the concentrations of potential allergens observed in commercial cereal extracts used for diagnosis, highlight the necessity to standardize and improve the diagnostic tools. Removal from exposure to the offending agents is the cornerstone of the management of grain-induced asthma. The availability of purified allergens should be very helpful for a more refined diagnosis, and new immunomodulatory treatments, including allergen immunotherapy and biological drugs, should aid in the management of patients with this disorder.
doi:10.4168/aair.2013.5.6.348
PMCID: PMC3810540  PMID: 24179680
Baker's asthma; cereals; wheat allergens; soya flour; fungal enzymes; allergen immunotherapy
16.  Genetic Variants in Antioxidant Genes Are Associated With Diisocyanate-Induced Asthma 
Toxicological Sciences  2012;129(1):166-173.
Diisocyanates are a common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes, glutathione S-transferases (GSTM1, GSTT1, GSTM3, GSTP1), manganese superoxide dismutase (SOD2), and microsomal epoxide hydrolase (EPHX1) are associated with increased susceptibility to diisocyanate-induced asthma (DA). The main study population consisted of 353 Caucasian French-Canadians from among a larger sample of 410 diisocyanate-exposed workers in three groups: workers with specific inhalation challenge (SIC) confirmed DA (DA+, n = 95); symptomatic diisocyanate workers with a negative SIC (DA−, n = 116); and asymptomatic exposed workers (AW, n = 142). Genotyping was performed on genomic DNA, using a 5′-nuclease PCR assay. The SOD2 rs4880, GSTP1 rs1695, and EPHX1 rs2740171 variants were significantly associated with DA in both univariate and multivariate analyses. In the first logistic regression model comparing DA+ and DA− groups, SOD2 rs4880, GSTM1 (null), GSTP1 rs762803, and EPHX1 rs2854450 variants were associated with DA (p = 0.004, p = 0.047, p = 0.021, p <0.001, respectively). Genotype combinations GSTT1*GSTP1 rs762803, GSTM1*EPHX1 rs2854450, EPHX1 rs2740168*EPHX1 rs1051741, and GSTP1 rs762803*EPHX1 rs2740168 were also associated with DA in this model (p = 0.027, p = 0.002, p = 0.045, p = 0.044, respectively). The GSTP1 rs1695 and EPHX1 rs1051741 and rs2740171 variants showed an association with DA in the second model comparing DA+ and AW groups (p = 0.040, p = 0.019, p = 0.002, respectively). The GSTM3 rs110913*EPHX1 rs1051741 genotype combination was also associated with DA under this model (p = 0.042). The results suggest that variations in SOD2, GST, and EPHX1 genes and their interactions contribute to DA susceptibility.
doi:10.1093/toxsci/kfs183
PMCID: PMC3499076  PMID: 22610343
diisocyanates;  occupational asthma;  antioxidant;  genetics;  single-nucleotide polymorphism.
17.  Research needs in allergy: an EAACI position paper, in collaboration with EFA 
Papadopoulos, Nikolaos G | Agache, Ioana | Bavbek, Sevim | Bilo, Beatrice M | Braido, Fulvio | Cardona, Victoria | Custovic, Adnan | deMonchy, Jan | Demoly, Pascal | Eigenmann, Philippe | Gayraud, Jacques | Grattan, Clive | Heffler, Enrico | Hellings, Peter W | Jutel, Marek | Knol, Edward | Lötvall, Jan | Muraro, Antonella | Poulsen, Lars K | Roberts, Graham | Schmid-Grendelmeier, Peter | Skevaki, Chrysanthi | Triggiani, Massimo | vanRee, Ronald | Werfel, Thomas | Flood, Breda | Palkonen, Susanna | Savli, Roberta | Allegri, Pia | Annesi-Maesano, Isabella | Annunziato, Francesco | Antolin-Amerigo, Dario | Apfelbacher, Christian | Blanca, Miguel | Bogacka, Ewa | Bonadonna, Patrizia | Bonini, Matteo | Boyman, Onur | Brockow, Knut | Burney, Peter | Buters, Jeroen | Butiene, Indre | Calderon, Moises | Cardell, Lars Olaf | Caubet, Jean-Christoph | Celenk, Sevcan | Cichocka-Jarosz, Ewa | Cingi, Cemal | Couto, Mariana | deJong, Nicolette | Del Giacco, Stefano | Douladiris, Nikolaos | Fassio, Filippo | Fauquert, Jean-Luc | Fernandez, Javier | Rivas, Montserrat Fernandez | Ferrer, Marta | Flohr, Carsten | Gardner, James | Genuneit, Jon | Gevaert, Philippe | Groblewska, Anna | Hamelmann, Eckard | Hoffmann, Hans Jürgen | Hoffmann-Sommergruber, Karin | Hovhannisyan, Lilit | Hox, Valérie | Jahnsen, Frode L | Kalayci, Ömer | Kalpaklioglu, Ayse Füsun | Kleine-Tebbe, Jörg | Konstantinou, George | Kurowski, Marcin | Lau, Susanne | Lauener, Roger | Lauerma, Antti | Logan, Kirsty | Magnan, Antoine | Makowska, Joanna | Makrinioti, Heidi | Mangina, Paraskevi | Manole, Felicia | Mari, Adriano | Mazon, Angel | Mills, Clare | Mingomataj, ErvinÇ | Niggemann, Bodo | Nilsson, Gunnar | Ollert, Markus | O'Mahony, Liam | O'Neil, Serena | Pala, Gianni | Papi, Alberto | Passalacqua, Gianni | Perkin, Michael | Pfaar, Oliver | Pitsios, Constantinos | Quirce, Santiago | Raap, Ulrike | Raulf-Heimsoth, Monika | Rhyner, Claudio | Robson-Ansley, Paula | Alves, Rodrigo Rodrigues | Roje, Zeljka | Rondon, Carmen | Rudzeviciene, Odilija | Ruëff, Franziska | Rukhadze, Maia | Rumi, Gabriele | Sackesen, Cansin | Santos, Alexandra F | Santucci, Annalisa | Scharf, Christian | Schmidt-Weber, Carsten | Schnyder, Benno | Schwarze, Jürgen | Senna, Gianenrico | Sergejeva, Svetlana | Seys, Sven | Siracusa, Andrea | Skypala, Isabel | Sokolowska, Milena | Spertini, Francois | Spiewak, Radoslaw | Sprikkelman, Aline | Sturm, Gunter | Swoboda, Ines | Terreehorst, Ingrid | Toskala, Elina | Traidl-Hoffmann, Claudia | Venter, Carina | Vlieg-Boerstra, Berber | Whitacker, Paul | Worm, Margitta | Xepapadaki, Paraskevi | Akdis, Cezmi A
In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.
The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.
Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.
doi:10.1186/2045-7022-2-21
PMCID: PMC3539924  PMID: 23121771
Allergy; Allergic diseases; Policy; Research needs; Research funding; Europe
18.  Measurement of asthma control according to global initiative for asthma guidelines: a comparison with the asthma control questionnaire 
Respiratory Research  2012;13(1):50.
Introduction
Asthma Control Questionnaire (ACQ) is a validated tool to measure asthma control. Cut-off points that best discriminate “well-controlled” or “not well-controlled” asthma have been suggested from the analysis of a large randomized clinical trial but they may not be adequate for daily clinical practice.
Aims
To establish cut-off points of the ACQ that best discriminate the level of control according to Global Initiative for Asthma (GINA) 2006 guidelines in patients with asthma managed at Allergology and Pulmonology Departments as well as Primary Care Centers in Spain.
Patients and methods
An epidemiological descriptive study, with prospective data collection. Asthma control following GINA-2006 classification and 7-item ACQ was assessed. The study population was split in two parts: 2/3 for finding the cut-off points (development population) and 1/3 for validating the results (validation population).
Results
A total of 1,363 stable asthmatic patients were included (mean age 38 ± 14 years, 60.3% women; 69.1% non-smokers). Patient classification according to GINA-defined asthma control was: controlled 13.6%, partially controlled 34.2%, and uncontrolled 52.3%. The ACQ cut-off points that better agreed with GINA-defined asthma control categories were calculated using receiver operating curves (ROC). The analysis showed that ACQ < 0.5 was the optimal cut-off point for “controlled asthma” (sensitivity 74.1%, specificity 77.5%) and 1.00 for “uncontrolled asthma” (sensitivity 73%, specificity 88.2%). Kappa index between GINA categories and ACQ was 0.62 (p < 0.001).
Conclusion
The ACQ cut-off points associated with GINA-defined asthma control in a real-life setting were <0.5 for controlled asthma and ≥1 for uncontrolled asthma.
doi:10.1186/1465-9921-13-50
PMCID: PMC3462124  PMID: 22726416
Asthma control; GINA guidelines; Asthma control questionnaire; Validation study
19.  Hexamethylene Diisocyanate Asthma is Associated with Genetic Polymorphisms of CD14, IL-13, and IL-4RA 
doi:10.1016/j.jaci.2011.03.007
PMCID: PMC3164978  PMID: 21489615
diisocyanate-induced asthma; occupational asthma; genetics of asthma; IL4RA (I50V); IL13 (R110Q); CD14 (C159T
20.  Suppressors of Cytokine Signaling 3 Expression in Eosinophils: Regulation by PGE2 and Th2 Cytokines 
Asthma and nonasthmatic eosinophilic bronchitis (NAEB) are respiratory disorders characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins play an important role in Th2-mediated allergic responses through control of the balance between Th1 and Th2 cells, particularly, SOCS3 and SOCS5. The aim of this study was to analyze SOCS expression in human peripheral blood eosinophils from patients with asthma, NAEB and healthy controls. SOCS expression in eosinophils from subjects was demonstrated by different techniques. Results showed that expression of SOCS3 in eosinophils and CD4 T cells from patients was higher than in healthy subjects. In addition, we demonstrated that prostaglandin E2 (PGE2) and Th2 cytokines are able to upregulate SOCS3 production in eosinophils and attenuate its degranulation. In conclusion, eosinophils are able to transcribe and translate SOCS3 protein and can contribute to the regulation of the Th1/Th2 balance through SOCS3 production.
doi:10.1155/2011/917015
PMCID: PMC3135166  PMID: 21765854
21.  Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps 
Respiratory Research  2011;12(1):38.
Background
Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (Symbicort SMART® Turbuhaler®) in patients previously prescribed treatments from Global Initiative for Asthma (GINA) Steps 2, 3 or 4.
Methods
This is a post hoc analysis of the results of five large clinical trials (>12000 patients) comparing BUD/FORM maintenance and reliever therapy with other treatments categorised by treatment step at study entry. Both current clinical asthma control during the last week of treatment and exacerbations during the study were examined.
Results
At each GINA treatment step, the proportion of patients achieving target levels of current clinical control were similar or higher with BUD/FORM maintenance and reliever therapy compared with the same or a higher fixed maintenance dose of inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) (plus short-acting β2-agonist [SABA] as reliever), and rates of exacerbations were lower at all treatment steps in BUD/FORM maintenance and reliever therapy versus same maintenance dose ICS/LABA (P < 0.01) and at treatment Step 4 versus higher maintenance dose ICS/LABA (P < 0.001). BUD/FORM maintenance and reliever therapy also achieved significantly higher rates of current clinical control and significantly lower exacerbation rates at most treatment steps compared with a higher maintenance dose ICS + SABA (Steps 2-4 for control and Steps 3 and 4 for exacerbations). With all treatments, the proportion of patients achieving current clinical control was lower with increasing treatment steps.
Conclusions
BUD/FORM maintenance and reliever therapy may be a preferable option for patients on Steps 2 to 4 of asthma guidelines requiring a more effective treatment and, compared with other fixed dose alternatives, is most effective in the higher treatment steps.
doi:10.1186/1465-9921-12-38
PMCID: PMC3082240  PMID: 21463522
22.  EAACI position paper on occupational rhinitis 
Respiratory Research  2009;10(1):16.
The present document is the result of a consensus reached by a panel of experts from European and non-European countries on Occupational Rhinitis (OR), a disease of emerging relevance which has received little attention in comparison to occupational asthma. The document covers the main items of OR including epidemiology, diagnosis, management, socio-economic impact, preventive strategies and medicolegal issues. An operational definition and classification of OR tailored on that of occupational asthma, as well as a diagnostic algorithm based on steps allowing for different levels of diagnostic evidence are proposed. The needs for future research are pointed out. Key messages are issued for each item.
doi:10.1186/1465-9921-10-16
PMCID: PMC2654869  PMID: 19257881

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