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author:("maxime, G")
2.  Synovial immunoglobulin and antibody in vaccinated and nonvaccinated calves challenged with Mycoplasma bovis. 
Intravenous injection of Mycoplasma bovis produced in calves arthritis with synovial infiltration of lymphocytes, macrophages and neutrophils. Necrosis was observed focally around blood vessels. Joint spaces contained fibrinopurulent exudate. Parenterally vaccinated calves had a markedly reduced frequency of arthritic joints. Immunoglobulin classes and specific antibody in joint fluids were quantitatively less than in sera but significantly greater in arthritic than in normal joints. The possible mechanisms of induction of joint fluid antibody are discussed.
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PMCID: PMC1320127  PMID: 7272847
3.  Investigation into the Role of Potentially Contaminated Feed as a Source of the First-Detected Outbreaks of Porcine Epidemic Diarrhea in Canada 
Summary
In January 2014, approximately 9 months following the initial detection of porcine epidemic diarrhea (PED) in the USA, the first case of PED was confirmed in a swine herd in south-western Ontario. A follow-up epidemiological investigation carried out on the initial and 10 subsequent Ontario PED cases pointed to feed as a common risk factor. As a result, several lots of feed and spray-dried porcine plasma (SDPP) used as a feed supplement were tested for the presence of PEDV genome by real-time RT-PCR assay. Several of these tested positive, supporting the notion that contaminated feed may have been responsible for the introduction of PEDV into Canada. These findings led us to conduct a bioassay experiment in which three PEDV-positive SDPP samples (from a single lot) and two PEDV-positive feed samples supplemented with this SDPP were used to orally inoculate 3-week-old piglets. Although the feed-inoculated piglets did not show any significant excretion of PEDV, the SDPP-inoculated piglets shed PEDV at a relatively high level for ≥9 days. Despite the fact that the tested PEDV genome positive feed did not result in obvious piglet infection in our bioassay experiment, contaminated feed cannot be ruled out as a likely source of this introduction in the field where many other variables may play a contributing role.
doi:10.1111/tbed.12269
PMCID: PMC4282400  PMID: 25098383
porcine epidemic diarrhea; spray-dried porcine plasma; transmission

Results 1-3 (3)