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1.  Production indices, calf health and mortality on seven red veal farms in Ontario. 
Production, morbidity, mortality and culling were investigated on seven commercial red veal farms in Ontario. The total number of calves included in the study group was 2251. The mean exit weight of marketed calves was 291 kg, with an average daily gain of 1.52 kg/day over the entire production period. The percentage of calves receiving one or more treatment days was 55%, with an average number of individual treatment days per treated calf of 3.9. An increasing number of treatment days, particularly up to eight days of treatment, was associated with decreasing average daily gain, and an increased probability of being lost from production due to death or culling. The percentage of calves which died during production was 5.4, with 0.8% of calves culled.
PMCID: PMC1263696  PMID: 7954122
2.  Production practices, calf health and mortality on six white veal farms in Ontario. 
A group of 4863 white veal calves reared on six commercial white veal farms in Ontario were followed through production to describe calf characteristics and production levels. Patterns of morbidity, mortality, and culling were investigated at the farm, room and individual level. The majority of the calves were male Holsteins, with approximately half originating from Ontario. The mean average daily gain for shipped calves over the entire production period was 1.1 kg/day (SE = 0.002). The overall percentage of calves receiving at least one individual treatment was 59%, with an average number of treatment days per calf of 3.3. The majority of calves receiving one or more treatment days were first treated between the fourth and seventh week of production. The mortality rate was 3.7%, and 5.1% of the calves were culled. Pneumonia was the largest single cause of death. Peak death and cull losses occurred during the seventh and eighth week of production.
PMCID: PMC1263695  PMID: 7954121
4.  Disseminated Intravascular Coagulation in a Horse with Postpartum Ulcerative Colitis and Laminitis 
The Canadian Veterinary Journal  1984;25(5):195-198.
Hemostatic studies were conducted on a five year old Belgian mare presented two days postpartum with colic and laminitis that was unresponsive to treatment.
The mare was moderately thrombocytopenic with plasma fibrinogen levels more than twice that of a normal control horse. Platelet function as evaluated by aggregometry indicated that the circulating platelets were markedly hyporesponsive. Activated partial thromboplastin times and prothrombin times were prolonged. Para-coagulation tests (protamine sulfate and ethanol gelation) were strongly positive and fibrin degradation products were significantly elevated in the serum.
The laboratory data suggested that the clinical bleeding was the result of the development of disseminated intravascular coagulation. The data were compatible with intravascular activation of the clotting mechanism, consumption of hemostatic factors, inhibition of platelet function and enhanced stimulation of the fibrinolytic mechanism.
This report illustrates the complexity of the hemostatic abnormalities associated with pathological overactivation of the hemostatic mechanism. Factors such as tissue thromboplastins and/or endotoxins can stimulate disseminated intravascular coagulation, particularly during pregnancy or in the early postpartum period when a physiological “hypercoagulable” state already exists.
PMCID: PMC1790563  PMID: 17422399
Equine; disseminated intravascular coagulation; laboratory diagnosis; pathology
5.  Isolation of Mycoplasma mycoides subspecies mycoides from Polyarthritis and Mastitis of Goats in Canada 
The clinical signs, pathomorphological changes, and microbiological findings in Canadian goats infected with Mycoplasma mycoides subspecies mycoides are discussed. The disease affected mainly young goats and was characterized by septicemia and polyarthritis. Mastitis followed by septicemia was seen in two mature goats. The diagnosis was made by culture and identification of the mycoplasma. Infected goats without clinical signs were identified by cultural and serological (complement fixation) techniques. Healthy carriers are presumably able to transmit the infection and may have brought the disease to Canada.
PMCID: PMC1790251  PMID: 17422225
6.  Enterotoxemia in the goat: the humoral response and local tissue reaction following vaccination with two different bacterin-toxoids. 
A vaccination trial involving 72 goats was designed to compare the epsilon antitoxin titres and local reactions at the injection sites, of two commercial enterotoxemia vaccines. Three dosage regimens were used for each vaccine (12 goats per group). Although no significant differences were noted in humoral immune response between the two vaccines (P = 0.05), one vaccine regime resulted in low titres (P = 0.05) on two occasions. Local tissue reactions at injection sites persisted for six months in 53% of the goats regardless of vaccine used or dosage administered. No immunological basis for the reported differences in vaccine efficacy between sheep and goats was observed in this trial.
PMCID: PMC1235905  PMID: 6309346
8.  Metabolism of isoprenaline after aerosol and direct intrabronchial administration in man and dog 
British Journal of Pharmacology  1974;50(4):587-591.
1 Administration of isoprenaline by aerosol inhalation to man results in over 80% being metabolized to the sulphate conjugate.
2 The majority of an inhaled dose is probably swallowed since the metabolic pattern resembles that after an oral dose.
3 Isoprenaline, administered in aqueous solution directly into the bronchial tree in both man and dog, is rapidly O-methylated to 3-O-methyl isoprenaline, which is subsequently conjugated with sulphate.
4 3-O-Methylation is the main metabolic pathway for the small part of an inhaled dose which does enter the bronchial tree.
PMCID: PMC1776727  PMID: 4447860
11.  Construction of a human chromosome 4 YAC pool and analysis of artificial chromosome stability. 
Nucleic Acids Research  1992;20(13):3419-3425.
In order to construct a human chromosome 4-specific YAC library, we have utilized pYAC4 and a mouse/human hybrid cell line HA(4)A in which the only human chromosome present is chromosome 4. From this cell line, approximately 8Mb of chromosome 4 have been cloned. The library includes 65 human-specific clones that range in size from 30kb to 290kb, the average size being 108kb. In order to optimize the manipulation of YAC libraries, we have begun to investigate the stability of YACs containing human DNA in yeast cells; these studies will also determine if there are intrinsic differences in the properties of chromosomes containing higher eukaryotic DNAs. We are examining two kinds of stability: 1] mitotic stability, the ability of the YAC to replicate and segregate properly during mitosis, and 2] structural stability, the tendency of the YAC to rearrange. We have found that the majority of YACs examined are one to two orders of magnitude less stable than authentic yeast chromosomes. Interestingly, the largest YAC analyzed displayed a loss rate typical for natural yeast chromosomes. Our results also suggest that increasing the length of an artificial chromosome improves its mitotic stability. One YAC that showed a very high frequency of rearrangement by mitotic recombination proved to be a mouse/human chimera. In contrast to studies using total human DNA, the frequency of chimeras (i.e., mouse/human) in the YAC pool appeared to be low.
PMCID: PMC312498  PMID: 1630913

Results 1-11 (11)