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1.  Body image in different periods of adolescence  
Revista Paulista de Pediatria  2014;32(1):63-69.
To analyze body image in different periods of adolescence.
This cross-sectional study enrolled students aged ten to 19 years old of public schools in small districts of Minas Gerais, Southeast Brazil. The Body Shape Questionnaire (BSQ), the Body Dissatisfaction Assessment Scale for Teenagers and the Silhouette Scale for Teenagers (SST) were used. Adolescence phases were classified according to the subjects' ages. Weight and height were measured in order to calculate the body mass index and the nutritional status. Results were analyzed by logistic regression.
The study emolled 531 teenagers (318 females). The average age was 15.6±
.2 years and 84.6% were eutrophic. The prevalence of body dissatisfaction varied from 28.9% (BSQ) to 78.9% (SST). Overweight adolescents presented greater dissatisfaction (BSQ: OR 3.66, p<0.001; SST: OR 4.108, p<0.001). Dissatisfaction also occurred for females and those at the early adolescence (p<0.05).
A low prevalence of dissatisfaction with the body image was observed among adolescents in small towns of Minas Gerais; however, most of them wished a different silhouette than the current one. The results showed that younger adolescents had higher dissatisfaction than their peers, as well as female and overweighed adolescents.
PMCID: PMC4182998  PMID: 24676192
body image; adolescent; sex; nutritional status; adolescent health
2.  Polyploids require Bik1 for kinetochore–microtubule attachment 
The Journal of Cell Biology  2001;155(7):1173-1184.
The attachment of kinetochores to spindle microtubules (MTs) is essential for maintaining constant ploidy in eukaryotic cells. Here, biochemical and imaging data is presented demonstrating that the budding yeast CLIP-170 orthologue Bik1is a component of the kinetochore-MT binding interface. Strikingly, Bik1 is not required for viability in haploid cells, but becomes essential in polyploids. The ploidy-specific requirement for BIK1 enabled us to characterize BIK1 without eliminating nonhomologous genes, providing a new approach to circumventing the overlapping function that is a common feature of the cytoskeleton. In polyploid cells, Bik1 is required before anaphase to maintain kinetochore separation and therefore contributes to the force that opposes the elastic recoil of attached sister chromatids. The role of Bik1 in kinetochore separation appears to be independent of the role of Bik1 in regulating MT dynamics. The finding that a protein involved in kinetochore–MT attachment is required for the viability of polyploids has potential implications for cancer therapeutics.
PMCID: PMC2199317  PMID: 11756471
kinetechore; microtubule; ploidy; Bik1; plus end–tracking protein

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