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Journal of Digital Imaging (1)
The Journal of Cell Biology (1)
Bluth, Edward I. (1)
Fink, Gerald R. (1)
Kho, David (1)
Kho, David Y. (1)
Lin, Haijiang (1)
Meenan, Christopher (1)
Nagy, Paul G. (1)
Pellman, David (1)
Pierre, Philippe (1)
Tai, Chin-Yin (1)
de Carvalho, Pedro (1)
Year of Publication
Certification of Imaging Informatics Professionals (CIIP): 2010 Survey of Diplomates
Bluth, Edward I.
Nagy, Paul G.
Journal of Digital Imaging
The Certification for Imaging Informatics Professionals (CIIP) program is sponsored by the Society of Imaging Informatics in Medicine and the American Registry of Radiologic Technologists through the American Board of Imaging Informatics. In 2005, a survey was conducted of radiologists, technologists, information technology specialists, corporate information officers, and radiology administrators to identify the competencies and skill set that would define a successful PACS administrator. The CIIP examination was created in 2007 in response to the need for an objective way to test for such competencies, and there have been 767 professionals who have been certified through this program to date. The validity of the psychometric integrity of the examination has been previously established. In order to further understand the impact and future direction of the CIIP certification on diplomats, a survey was conducted in 2010. This paper will discuss the results of the survey.
PACS administration; Informatics training; Medical informatics applications
Polyploids require Bik1 for kinetochore–microtubule attachment
de Carvalho, Pedro
Fink, Gerald R.
The Journal of Cell Biology
The attachment of kinetochores to spindle microtubules (MTs) is essential for maintaining constant ploidy in eukaryotic cells. Here, biochemical and imaging data is presented demonstrating that the budding yeast CLIP-170 orthologue Bik1is a component of the kinetochore-MT binding interface. Strikingly, Bik1 is not required for viability in haploid cells, but becomes essential in polyploids. The ploidy-specific requirement for BIK1 enabled us to characterize BIK1 without eliminating nonhomologous genes, providing a new approach to circumventing the overlapping function that is a common feature of the cytoskeleton. In polyploid cells, Bik1 is required before anaphase to maintain kinetochore separation and therefore contributes to the force that opposes the elastic recoil of attached sister chromatids. The role of Bik1 in kinetochore separation appears to be independent of the role of Bik1 in regulating MT dynamics. The finding that a protein involved in kinetochore–MT attachment is required for the viability of polyploids has potential implications for cancer therapeutics.
kinetechore; microtubule; ploidy; Bik1; plus end–tracking protein
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