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1.  Anti-diabetic formulations of Nāga bhasma (lead calx): A brief review 
Ancient Science of Life  2013;33(1):52-59.
Introduction:
Ayurvedic formulations usually contain ingredients of herbal, mineral, metal or animal in origin. Nāga bhasma (lead calx) is a potent metallic formulation mainly indicated in the treatment of Prameha (~diabetes). Until date, no published information is available in compiled form on the formulations containing Nāga bhasma as an ingredient, their dose and indications. Therefore, in the present study, an attempt has been made to compile various formulations of Nāga bhasma indicated in treating Prameha.
Aim:
The present work aims to collect information on various formulations of Nāga bhasma mainly indicated in treating Prameha and to elaborate the safety and efficacy of Nāga bhasma as a Pramehaghna (antidiabetic) drug.
Materials and Methods
Critical review of formulations of Nāga bhasma is compiled from various Ayurvedic texts and the therapeutic efficacy of Nāga bhasma is discussed on the basis of available data.
Result and Conclusion:
Antidiabetic formulations of Nāga bhasma were discovered around 12th century CE. There are 44 formulations of Nāga bhasma mainly indicated for Prameha. Haridrā (Curcuma longa Linn), Āmalakī (Emblica officinalis), Guḍūci (Tinospora cordifolia) and Madhu (honey) enhance the antidiabetic action of Nāga bhasma and also help to prevent diabetic complications as well as any untoward effects of Nāga bhasma. On the basis of the reviewed research, it is concluded that Nāga bhasma possesses significant antidiabetic property.
doi:10.4103/0257-7941.134609
PMCID: PMC4140024  PMID: 25161332
Antidiabetic formulations; efficacy; Nāga bhasma; safety
2.  Acute and Subchronic Toxicity Study of Tamra Bhasma (Incinerated Copper) prepared from Ashodhita (Unpurified) and Shodhita (Purified) Tamra in Rats 
The use of metals in traditional medicines is very often seen as matter of concern these days, especially the Bhasma preparations which are always under stringent observations for containing highly reactive inorganic elements such as lead, mercury, arsenic and others. One of the Bhasma extensively used in routine Ayurvedic practice is Tamra (copper) bhasma. If it is not prepared properly or Shodhana procedure is not done properly, it acts as a poison. To indicate its toxic potential, Ashtamahadoshas (eight major ill effects) have been quoted in classics and due emphasis have been given to its Shodhana procedure. In the present study, Tamra bhasma prepared from Shodhita and Ashodhita Tamra was subjected to oral toxicity study to ascertain the role of Shodhana process on safety profile of Tamra bhasma on subchronic administration to albino rats. Both the samples were administered to rats for 45 consecutive days at the doses of 5.5, 27.5, and 55 mg/kg. Animals were sacrificed on 46th day and parameters like hematological, serum biochemical, and histopathology of various organs were studied. Results showed that Tamra bhasma prepared from Ashodhita Tamra has pathological implications on different hematological, serum biochemical and cytoarchitecture of different organs even at therapeutic dose level (5.5 mg/kg). Whereas, Tamra bhasma prepared from Shodhita Tamra is safe even at five-fold to therapeutic equivalent doses (27.5 mg/kg). These observations emphasize the role of Shodhana and importance of dose in expression of toxicity of the medicinal preparations.
doi:10.4103/0250-474X.117433
PMCID: PMC3783753  PMID: 24082351
Amrutikarana; copper; herbomineral formulation; LD50; Marana; Shodhana
3.  Ayurvedic management of adverse drug reactions with Shvitrahara Varti 
Ayu  2013;34(2):189-192.
Adverse drug reactions (ADR) are an expression that describes harm associated with the use of medications at therapeutic dose. Traditional medicines also can develop ADRs due to their improper use. Shvitrahara Varti, one of such medicines holds Bakuchi as a component and is to be used judiciously. Furanocoumarins like psoralen present in Bakuchi makes skin hypersensitive and causes phytophotodermatitis in few cases. Hence, one should be careful while using medicines that contain Bakuchi. One such case is observed, where extensive reactions with application of Shvitrahara Varti were noticed and managed with Ayurvedic treatment.
doi:10.4103/0974-8520.119676
PMCID: PMC3821249  PMID: 24250129
Adverse drug reactions; Bakuchi; blisters; Shvitra; Shvitrahara Varti; vitiligo
4.  PA01.58. Role of laghu malini vasanta rasa in management of madhumeha, type 2 diabetes mellitus 
Ancient Science of Life  2012;32(Suppl 1):S108.
Purpose:
Laghu Malini Vasanta Rasa is a Vasanta Malati Kalpa with Rasaka and Maricha as main ingredients, chiefly acting on Dhatvagni with Brimhana effect. It had been quoted by 30 texts and mentioned under Jeerna Jwaradhikara. None of text had mentioned it for Madhumeha. Madhumeha is chronic disorder where Dhatvagnimandya leads to diminution of Prasada Dhatu resulting in Vataprakopa. Type 2 Diabetes Mellitus is more prevalent among other types 62.4 million in 2011. Long termed hyperglycemia in Type 2 DM results in decreased quality of life 2.263 million disability adjusted life years in India during 2004. Through present study attempt was made to evaluate efficacy of formulation (AFI part I 20:36) in Madhumeha as anti-hyperglycaemic activity of ingredients of Laghu Malini Vasanta Rasa has been recognized.
Method:
Open trial (CTRI registration no. CTRI/2011/11/00211) Inclusion criteria-Age group 30 60 yrs, Patients with cardinal symptoms of Madhumeha Exclusion criteria-Age group <30 >60yrs, Accelerated HTN, Pregnant, Lactating mother, CNS complication Diagnostic criteria-Subjective criteria: Classical signs & symptoms of Madhumeha, Objective criteria: FBS (fasting blood sugar) >126 mg/dl OR PPBSL (postprandial blood sugar level) >200 mg/dl, Total Reg.patient-33; completed-30; Dropped out-3, Posology with duration of treatment: 250mg tablet BD 30 min. before meal with lukewarm water for 8 weeks. Criteria for assessment: Relief in symptoms by Wilcoxson signed rank method. Unpaired t test for statistical analysis of objective parameters.
Result:
Highly significant relief p < 0.001in symptoms Klama, Daurbalya and significant relief P < 0.05 in reducing urine sugar and PPBSL (postprandial blood sugar level).
Conclusion:
Laghu Malini Vasanta helped to improve quality of life in-patient of Madhumeha.
PMCID: PMC3800861
5.  OA01.02. Literary Study on Heavy Metal Poisoning and Ayurveda with Special Reference to Naga Bhasma (Calcined Lead) 
Ancient Science of Life  2012;32(Suppl 1):S2.
Bhasmas are unique Ayurvedic metallic preparations with herbal juices/fruits widely used for treatment of a variety of chronic ailments. The bhasmas are products of classical alchemy, organo-metallic compounds of certain metals and gems in a very fine powdered form, mostly oxides, made in elaborate calcination processes perfected several centuries ago. Recent articles pertaining the alarming level of heavy metals, especially Pb, Hg, and As in Ayurvedic formulations have created a lot of controversy regarding the safety and efficacy of Ayurvedic formulations. It has been reported that lead, mercury, and arsenic have been detected in a substantial proportion of Indian-manufactured traditional Ayurvedic medicines. An attempt was made to study heavy metal poisoning with special reference to current research on toxicity of Naga bhasma. This study clearly shows that Naga bhasma is not just lead, it's a compound form predominantly crystalline i.e. mixture of PbO Pb3O4. XRD data revealed OH and (CO3) 2 group which contain some other essential elements in minute quantity and didn’t have any toxic effect at LD50 which was 160 times higher to that of Therapeutic Equivalent Dose (TED) (12.5 mg/kg) in acute toxicity study.
PMCID: PMC3800896
6.  Immunomodulatory activity of Āmalaki Rasāyana: An experimental evaluation 
Ancient Science of Life  2012;32(2):93-98.
Background:
Ayurvedic system of medicine holds a number of drugs that improves the immunity. Āmalaki (Emblica officinalis) is one such drug. Researches with crude extracts of Āmalaki have proven the antioxidant and immunomodulatory activities. But, works on Āmalaki Rasāyana are not found reported.
Aims:
Considering this, two samples of Āmalaki Rasāyana (AR7 and AR21) were studied to evaluate comparative immunomodulatory activity against the cyclophosphamide immunosuppression in rats.
Materials and Methods:
Test drugs were prepared by following classical guidelines. Wistar strain albino rats of either sex were used in the study.
Statistical Analysis:
For comparison of data from cyclophosphamide control group with remaining cyclophosphamide plus test drug administered groups one way ANOVA with Dunnett's multiple t-test (DMTT) was employed.
Results and Conclusions:
Āmalaki Rasāyana possesses significant immunostimulant activity and moderate cytoprotective activity. AR21 was found to have better activity profile in terms of both immunostimulant as well as cytoprotective activity.
doi:10.4103/0257-7941.118546
PMCID: PMC3807964  PMID: 24167334
Āmalaki; cyclophosphamide; Ghrita; humoral immunity; Madhu; Rasāyana
7.  Preparation of Dhatryarishta by Dhatri Swarasa and Dhatri Kwatha 
Ayu  2011;32(2):265-270.
Dhatryarishta has been described for the first time in Charaka Samhita, in the context of Panduroga. The same reference is available in Chakradatta, Bhaishajya Ratnavali, and Sahastrayogam too. Generally Dhatri Swarasa [Amalaki (Emblica officinalis Gaertn.)] is used in the preparation of Dhatryarishta as per classical reference, but fresh Amalaki is not available in every season, so in the present study, Amalaki Kwatha (decoction) is used instead of Swarasa. A total of 13 batches of Dhatryarishta were prepared, out of which nine batches were prepared with Dhatri Swarasa and four batches with Dhatri Kwatha. For Dhatryarishta prepared by using Dhatri Swarasa, three methods were applied and in Dhatryarishta prepared by using Dhatri Kwatha two methods were applied. The study revealed that Dhatryarishta could only be prepared by using Amalaki Swarasa as quoted in the classics and not by using Amalaki Kwatha.
doi:10.4103/0974-8520.92548
PMCID: PMC3296352  PMID: 22408314
Dhatri; Dhatryarishta; Kwatha; Panduroga; Swarasa
8.  Critical review on the pharmaceutical vistas of Lauha Kalpas (Iron formulations) 
Iron is one among the major metals present in the earth's crust and is essential for sound sustenance of human body. Its deficiency leads to various health ailments. Contemporary medicine advises iron supplements in iron deficiency anemia. Ayurvedic classics also quote significant information about administration of iron. Lauha Kalpas are the unique compound herbo-mineral formulations where iron (Lauha) is used as a major ingredient. Relevant literature (Bhaishajya Ratnavali, Charaka Samhita, Rasendra Sara Samgraha etc.) reviewed to gather information about Lauha Kalpas. Critical analysis of these Lauha Kalpas reveals that ancient seers administered iron in a better acceptable form. Unlike popular understanding these are not only Khalviya preparations; but Churna (powders), Avaleha (confectionaries), Rasakriya (solidified decoctions), and Putapaka (incinerated) form of preparations are also found. Apart from solid dosage forms, semisolid dosage forms mentioned in classics are very much useful. Unfortunately most of the formulations are not found in the market. Hence Pharmaceutical firms may bring these unique dosage forms in to the market to supply the healthcare needs of the community. It is interesting that iron preparations are used in Ayurveda in different medical conditions apart from anemia (Pandu). This leaves a scope for further researches on different dosage forms of iron and their indications.
doi:10.4103/0975-9476.93944
PMCID: PMC3326790  PMID: 22529676
Ayurveda; Bhasma; Hematinics; Iron; Lauha Kalpa; pharmaceutics; Rasaushadhi
9.  Pharmacognostical and physicochemical analysis of Tamarindus indica Linn. stem 
Tamarindus indica Linn. fruits (Chincha) are extensively used in culinary preparations in Indian civilization. Its vast medicinal uses are documented in Ayurvedic classics and it can be used singly or as a component of various formulations. Besides fruit, the Kasta (wood) of T. indica L. is also important and used to prepare Kshara (alkaline extract) an Ayurvedic dosage form. Pharmacognostical and physicochemical details of Chincha Kasta are not available in authentic literature including API (Ayurvedic Pharmacopoeia of India). The study is an attempt in this direction. T. indica L. stem with heartwood was selected and morphological, microscopic and physicochemical standardization characters along with TLC finger print, and fluorescence analysis were documented. Transverse section of stem showed important characters such as phelloderm, stone cells layer, fiber groups, calcium oxalate, crystal fibers, and tylosis in heartwood region. Four characteristic spots were observed under UV long wave, in thin layer chromatography with the solvent combination of toluene: ethyl acetate (8:2). The study can help correct identification and standardization of this plant material.
doi:10.4103/0975-9476.93939
PMCID: PMC3326798  PMID: 22529673
Ayurveda; Chincha; powder microscopy; tamarind; thin layer chromatography
10.  Pharmaceutical standardization of Jala Shukti Bhasma and Mukta Shukti Bhasma 
Ayu  2012;33(1):136-142.
Shukti is an important component of Sudha Varga, which is considered as the latest class in the field of Rasa Shastra. Two types of Shukti have been mentioned in Rasa Shastra texts i.e. Jala Shukti and Mukta Shukti according to the availability. In present study, an attempt has been made to develop a standard manufacturing procedure (SMP) of Jala Shukti Bhasma and Mukta Shukti Bhasma. Five batches of Jala Shukti Bhasma and Mukta Shukti Bhasma were prepared and standardization was attempted by maintaining batch manufacturing records of individual batches. During pharmaceutical procedures like Shodhana, Bhavana, Marana, etc. due care of temperature, its duration, percentage of weight gain or loss and the cost factor of the end product, etc. were considered. The average weight loss observed was 12.08 g i.e. 2.42% and 14.62 g i.e. 2.92% during Jala Shukti and Mukta Shukiti Shodhana respectively. Average weight loss found was 38.94 g i.e. 7.79% in Jala Shukti Bhasma while in Mukta Shukti Bhasma, it was 35.24 g i.e. 7.05%. At the end of the pharmaceutical procedure, it was found that Mukta Shukti Bhasma is 2.8 times costlier than Jala Shukti Bhasma.
doi:10.4103/0974-8520.100331
PMCID: PMC3456852  PMID: 23049199
Bhasma; Jala Shukti; Marana; Mukta Shukti; Shodhana
11.  Standardization of Shirishavaleha with reference to physico-chemical characteristics 
Ayu  2011;32(4):560-565.
Ten batches of Shirishavaleha were prepared by using Twak (Bark) and Sara (Heartwood) of Shirisha [Albizzia lebbeck Benth]. The adopted formulation was based on Shirisharishta of Bhaishajya Ratnavali. Though Shirisharishta has significant therapeutic effect in cases of Tamaka swasa, etc.; it has few difficulties during the pharmaceutical procedure like consuming long time, climatic influences etc. Considering these inconveniencies, the formulation composition has been converted in to Shirishavaleha. Avaleha has been prepared by using Twak and Sara of Shirisha. No significant differences were found in pharmaceutical aspects of both the samples of Shirishavaleha and the current method of preparation can be considered as standard. Attempts were also made to develop analytical profile of avaleha, which were almost similar in both the samples, except showing more Rf values in High Performance Thin Layer Chromatography profile of Sara group.
doi:10.4103/0974-8520.96134
PMCID: PMC3361936  PMID: 22661855
Albizzia lebbeck; Avaleha; Bark; Heartwood; Shirisha; Shirishavaleha
12.  Therapeutic potentials of metals in ancient India: A review through Charaka Samhita 
The Ayurvedic system of medicine has stood the test of time for four millennia or more. The ancient seers found that drugs of different origin (herbal, metal or animal) in addition to codes of conduct and dietary regulations are suitable tools to maintain health in healthy and eradicating diseases in diseased. Use of metallic preparations in healthcare is a unique feature in this system. Processed metals including Mercury, Gold, Silver, Lead, Zinc, Copper etc. were used very frequently by seers of the Indian tradition in different disease conditions with great authority. It is generally claimed, that these metals are detoxified during the highly complex manufacturing processes described in Ayurvedic, especially Rasashastra texts. Charaka Samhita, one of the scheduled books of Ayurveda also holds ample of references regarding the use of metals for different purposes, which are summarized in the current paper.
doi:10.4103/0975-9476.82523
PMCID: PMC3131772  PMID: 21760689
Ayurveda; Charaka Samhita; lead; mercury; metals
13.  Standard manufacturing process of Makaradhwaja prepared by Swarna Patra – Varkha and Bhasma 
Ayu  2011;32(1):109-115.
Makaradhwaja is an important Kupipakwa Rasayana. It is prepared by using Swarna (gold), Parada (mercury) and Gandhaka (sulfur) in different ratios, i.e. 1:8:16, 1:8:24 and 1:2:4, respectively. The amount of Gandhaka in the Jarana process is directly proportional to the increase in therapeutic efficacy and reduces the toxicity of the product. Specific temperature pattern for the preparation of Makaradhwaja has been followed. In the present study Swarna, Parada and Gandhaka were taken in the ratio 1:8:24, respectively, and 12 h of heating for a specified amount of Kajjali (i.e., 400 g) in a Kacha Kupi 1/3rd of its capacity. There are some controversies regarding the form of Swarna (i.e., Swarna Patra Swarna Varkha or Swarna Bhasma) used in the preparation of Makaradhwaja. Therefore, in the present study, the samples of Makaradhwaja were prepared by Swarna Patra, Varkha and Bhasma in different batches. It was found that the use of Varkha produced a good-quality product along with the maximum amount of gold, i.e. 268 ppm, in comparison with Patra, i.e. 131 ppm, and Bhasma, i.e. 19 ppm, respectively.
doi:10.4103/0974-8520.85741
PMCID: PMC3215406  PMID: 22131768
Bhavana; Hingulottha Parada; Kupipaka; Standard manufacturing process; Shodhana
14.  Sedative Hypnotic Activity of Manahshila (Realgar) -An Experimental Evaluation 
Ancient Science of Life  2011;30(3):78-83.
Manahshila (Realgar) is one of the three major Arsenicals used in Ayurvedic therapeutics since ages. It is indicated in skin, respiratory, ophthalmic and psychological disorders. It is mentioned to be the best among Rasayanas and a good aphrodisiac. As Manahshila is indicated in Unmada (Psychological disorder); wide use of Manahshila in the formulations mentioned for psychological disorders; some of those formulations are used in treatment of sleeplessness and Ardraka (Zingiber officinale Roscoe) which is a commonly used Shodhana reagent of Manahshila is reported to be sedative, the potential sedative hypnotic activity is inferred and an experimental study was carried out to evaluate the sedative hypnotic activity of Manahshila. Effect of Ardraka Shodhita Manahshila (ASM) on the spontaneous motor activity of albino rats in actophotometer and on diazepam induced sleeping time was evaluated. There was a statistically significant reduction in the spontaneous motor activity (P<0.001) in the ASM treated Manahshila and there was early onset and hypnotic potentiation in the diazepam induced sleep in rats (P<0.01).
PMCID: PMC3336258  PMID: 22557432
Sedative hypnotic; Spontaneous Motor Activity; Actophotometer; Sleeping Time Test; Psychological Disorders
15.  A comparative pharmacological evaluation of Taila (oil) and Ghrita (ghee) prepared with Guduchi (Tinospora cordifolia) 
Ayu  2010;31(4):504-508.
Guduchi (Tinospora cordifolia wild miers) is a well-known medicinal plant, which is abundantly used in different ayurvedic formulations utilizing varieties of media. The drug has properties like Rasayana (rejuvenating property), Krimighna (anthelmintics), and Kushtghna (used in skin disorders), as described in ayurvedic literature. Taila (oil) and Ghrita (ghee) are used as media in Ayurvedic Sneha (oleaginous) formulations. Both the test drugs, Guduchi Taila and Ghrita, are prescribed in Vatrakta (gout) and also indicated for Kushtha (skin disorder). With all these details, the Guduchi Taila and Guduchi Ghrita samples, prepared by using Taila and Ghrita as media, have been subjected to comparative pharmacological investigations, to assess the impact of the media on the expression of pharmacological activity. The formulations have been evaluated for immunomodulation, anti-inflammatory, and anti-stress activities. Both the formulations have been found to be active in most of the experiments, however, with the change of media, their results vary at different levels. Taila prepared from Guduchi was found to have an immunostimulating activity. The formulation prepared with Ghrita exhibited an anti-stress effect with an immunosuppressing activity.
doi:10.4103/0974-8520.82036
PMCID: PMC3202249  PMID: 22048548
Guduchi (Tinospora cordifolia wild miers); Guduchi Taila; Guduchi Ghrita; Immunomodulation; Anti-inflammatory; Anti-stress
16.  Standardization of Gaja Puta and Ardha Gaja Puta in the preparation of Vanga Bhasma 
Ayu  2010;31(4):511-515.
The Vanga Bhasma is an important one amongst the metallic Bhasmas. Mainly Gaja Puta, Ardhagaja Puta and Laghu Puta have been described for Marana of Vanga. The medicines, which are prepared from Gaja Puta, are said to be the best ones (Mahagunavidhayaka). Gaja Puta is commonly used in the preparation of almost all the Bhasmas. There are a few references found in classics regarding Ardhagaja Puta, but not any reference regarding its detail description, therefore, the effort was made to standardize both the Putas with regard to Vanga Bhasma. In the present study, Vanga Bhasma was prepared by Gaja Puta and Ardhagaja Puta. For Marana of Vanga, it was found that the Ardhagaja Puta is more convenient than Gaja Puta with respect to color and particle size analysis of Bhasma after Jarana procedure of Vanga.
doi:10.4103/0974-8520.82028
PMCID: PMC3202267  PMID: 22048550
Gaja Puta; Ardhagaja Puta; Shodhana; Jarana; Marana
17.  Standard manufacturing procedure for syrup and tablet forms of Jwarahara Dashemani 
Ayu  2010;31(2):255-259.
Jwarahara Dashemani (JHD) is mentioned by Acharya Charaka under the different categories of Mahakashayas (groups of drugs having similar pharmacological actions). For the present study, syrup and tablet forms of JHDs were prepared and analyzed. The formulations were prepared in various batches by following the standard manufacturing procedure (SMP). JHD Kwatha (2200 ml) and 1430 g sugar candy powder were heated (80–90°C) together for 3.10 hours and 2200 ml syrup was obtained, whereas an average of 446 g of tablet was obtained from the mixture of 285 g Ghana and powder of sugar candy (125 g), JHD Dravyas (55 g) and talc (18 g). These formulations were subjected to various analytical parameters and the results were observed on the basis of preparation.
doi:10.4103/0974-8520.72411
PMCID: PMC3215375  PMID: 22131721
Jwarahara Dashemani; Kwatha; ghana; standard manufacturing procedure; syrup; tablet
18.  Role of different media in Karpanpatru Taila preparation 
Ayu  2010;31(1):15-18.
Total six samples of Karpanpatru Taila were prepared with Murchchhita and Amurchchhita Sarshapa Taila (mustard oil) by using three different liquid media i.e. Gomutra, Takra and Kanji by following classical method and analyzed. The pharmaceutical analysis revealed that the Karpanpatru Taila prepared with Murchchhita Sarshapa taila by using Kanji, Gomutra, Takra as a liquid media showed minimum loss i.e. 4.00%, 8,33% & 8.66 respectively in comparison to Amurchchhita Sarshapa Taila by using Kanji, Gomutra, Takra i.e. 5.5%, 10.68%, 12% respectively. Pharmaceutical drawbacks like excessive frothing and burning of eyes & nose were absent during the preparation of Karpanpatru Taila with Takra and Kanji while present in batch of Gomutra. Analytical study reveals that Acid value was negligible increased after even 6 month in the samples of Murchchhita Karpanpatru Taila while significant increased in the samples of Amurchchhita Karpanpatru Taila. Saponification value was decreased in the samples of Murchhita Karpanpatru Taila while increased in the samples Amurchchhita Karpanpatru taila. Microbial growth was found absent in all the samples of Karpanpatru Taila even after 6 months.
doi:10.4103/0974-8520.68198
PMCID: PMC3215315  PMID: 22131678
Sneha Kalpana; Murchchhana; Gomutra; Takra; Kanji;  Acid value; Saponification value
19.  Process Standardization of Rasamanikya 
Ayu  2010;31(1):7-11.
Rasamanikya is a famous drug, frequently used by Ayurvedic physicians for Vata-Kaphaja diseases like Shwasa, Kasa and Kushtha (Skin disorders). Various methods of preparation have been found described in Rasa classics. Generally it is prepared by Shuddha Haratala which is kept between two thin transparent Abharaka Patra (mica sheets) in small scale and in sharava for large scale, heated up to desired level. There are so many methods and different liquid media have been found described for Shodhana of Haratala. Therefore the methods of preparation of Rasamanikya and Shodhana process of Haratala have been validated through various experiments. Tankana-treated Haratala (T. Treated) is found best for Shodhana process and final product too i.e. Rasamanikya in terms of pharmaceutical standards i.e. Ruby in colour, along with reproducibility of fixed quality.
doi:10.4103/0974-8520.68195
PMCID: PMC3215326  PMID: 22131676
Shodhana; Validation; T-Treated Haratala
20.  Neutraceuticals in Ayurveda with special reference to Avaleha Kalpana 
Ancient Science of Life  2008;28(2):29-32.
The use of Neutraceuticals has drastically risen in recent years. Dr Stephan De Felice coined the term Neutraceuticals from “nutrition” and “pharmaceutical” in 1989. Related terms are “functional food” and “dietary supplement”. In Ayurvedic pharmaceutics there are some secondary preparations like Avaleha Kalpana (Medicated semisolid preparation), Asavarista Kalpana (fermented preparation), Sneha Kalpana (Medicated fatty preparation), Ksheerapaka Kalpana (Medicated milk preparation) etc. which can be correlated with Neutraceuticals. In this paper “Neutraceuticals” and “Avaleha Kalpana” have been correlated and discussed.
PMCID: PMC3336349  PMID: 22557309
Neutraceuticals; Functional food; Avaleha Kalpana

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