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Nucleic Acids Research (1)
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Benini, Luca (2)
Bonora, Elena (1)
Brunelli, Davide (1)
Caione, Carlo (1)
Farella, Elisabetta (1)
Macii, Enrico (1)
Masotti, Daniele (1)
Milosevic, Bojan (1)
Nardini, Christine (1)
Romeo, Giovanni (1)
Rossi, Simona (1)
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Year of Publication
Sub-Sampling Framework Comparison for Low-Power Data Gathering: A Comparative Analysis
Sensors (Basel, Switzerland)
A key design challenge for successful wireless sensor network (WSN) deployment is a good balance between the collected data resolution and the overall energy consumption. In this paper, we present a WSN solution developed to efficiently satisfy the requirements for long-term monitoring of a historical building. The hardware of the sensor nodes and the network deployment are described and used to collect the data. To improve the network's energy efficiency, we developed and compared two approaches, sharing similar sub-sampling strategies and data reconstruction assumptions: one is based on compressive sensing (CS) and the second is a custom data-driven latent variable-based statistical model (LV). Both approaches take advantage of the multivariate nature of the data collected by a heterogeneous sensor network and reduce the sampling frequency at sub-Nyquist levels. Our comparative analysis highlights the advantages and limitations: signal reconstruction performance is assessed jointly with network-level energy reduction. The performed experiments include detailed performance and energy measurements on the deployed network and explore how the different parameters can affect the overall data accuracy and the energy consumption. The results show how the CS approach achieves better reconstruction accuracy and overall efficiency, with the exception of cases with really aggressive sub-sampling policies.
wireless sensor networks; low-power design; data reconstruction; compressive sensing; latent variables
TOM: a web-based integrated approach for identification of candidate disease genes
Nucleic Acids Research
2006;34(Web Server issue):W285-W292.
The massive production of biological data by means of highly parallel devices like microarrays for gene expression has paved the way to new possible approaches in molecular genetics. Among them the possibility of inferring biological answers by querying large amounts of expression data. Based on this principle, we present here TOM, a web-based resource for the efficient extraction of candidate genes for hereditary diseases. The service requires the previous knowledge of at least another gene responsible for the disease and the linkage area, or else of two disease associated genetic intervals. The algorithm uses the information stored in public resources, including mapping, expression and functional databases. Given the queries, TOM will select and list one or more candidate genes. This approach allows the geneticist to bypass the costly and time consuming tracing of genetic markers through entire families and might improve the chance of identifying disease genes, particularly for rare diseases. We present here the tool and the results obtained on known benchmark and on hereditary predisposition to familial thyroid cancer. Our algorithm is available at .
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