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1.  Web services at the European Bioinformatics Institute-2009 
Nucleic Acids Research  2009;37(Web Server issue):W6-W10.
The European Bioinformatics Institute (EMBL-EBI) has been providing access to mainstream databases and tools in bioinformatics since 1997. In addition to the traditional web form based interfaces, APIs exist for core data resources such as EMBL-Bank, Ensembl, UniProt, InterPro, PDB and ArrayExpress. These APIs are based on Web Services (SOAP/REST) interfaces that allow users to systematically access databases and analytical tools. From the user's point of view, these Web Services provide the same functionality as the browser-based forms. However, using the APIs frees the user from web page constraints and are ideal for the analysis of large batches of data, performing text-mining tasks and the casual or systematic evaluation of mathematical models in regulatory networks. Furthermore, these services are widespread and easy to use; require no prior knowledge of the technology and no more than basic experience in programming. In the following we wish to inform of new and updated services as well as briefly describe planned developments to be made available during the course of 2009–2010.
doi:10.1093/nar/gkp302
PMCID: PMC2703973  PMID: 19435877
2.  Transfer of Conjugative Elements from Rumen and Human Firmicutes Bacteria to Roseburia inulinivorans▿  
Applied and Environmental Microbiology  2008;74(12):3915-3917.
Studies on Firmicutes bacteria from the gut are hampered by a lack of gene transfer systems. Here the human colonic anaerobe Roseburia inulinivorans A2-194 was shown to be a transfer recipient for two conjugative transposons, Tn1545 from Eubacterium cellulosolvens and TnK10 from Clostridium saccharolyticum K10.
doi:10.1128/AEM.02807-07
PMCID: PMC2446557  PMID: 18456856
3.  Successful Boosting of a DNA Measles Immunization with an Oral Plant-Derived Measles Virus Vaccine 
Journal of Virology  2002;76(15):7910-7912.
Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.
doi:10.1128/JVI.76.15.7910-7912.2002
PMCID: PMC136403  PMID: 12097606

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