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1.  CONTRIBUTIONS OF HEBB AND VYGOTSKY TO AN INTEGRATED SCIENCE OF MIND 
Hebb and Vygotsky are two of the most influential figures of psychology in the first half of the 20th century. They represent cultural and biological approaches to explaining human development, and thus a number of their ideas remain relevant to current psychology and cognitive neuroscience. In this paper we examine similarities and differences between these two important figures, exploring possibilities for a theoretical synthesis between their two literatures, which have had little contact each other. To pursue these goals the following topics are discussed: 1) Hebb and Vygotsky’s lives and training; 2) their innovations in theory building relating to an “objective psychology” and objective science of mind, 3) their developmental approach, 4) their treatment of mediation and neuropsychology and 5) their current relevance and possible integration of their views. We argue that considering the two together improves prospects for a more complete and integrated approach to mind and brain in society.
doi:10.1080/0964704X.2012.761071
PMCID: PMC3691348  PMID: 23679195
Development; Hebb; Cell-assembly; Integrated science of mind; Luria; Mediation; Mind and mental activity; Neuropsychology; Vygotsky
2.  Improving creativity performance by short-term meditation 
Background
One form of meditation intervention, the integrative body-mind training (IBMT) has been shown to improve attention, reduce stress and change self-reports of mood. In this paper we examine whether short-term IBMT can improve performance related to creativity and determine the role that mood may play in such improvement.
Methods
Forty Chinese undergraduates were randomly assigned to short-term IBMT group or a relaxation training (RT) control group. Mood and creativity performance were assessed by the Positive and Negative Affect Schedule (PANAS) and Torrance Tests of Creative Thinking (TTCT) questionnaire respectively.
Results
As predicted, the results indicated that short-term (30 min per day for 7 days) IBMT improved creativity performance on the divergent thinking task, and yielded better emotional regulation than RT. In addition, cross-lagged analysis indicated that both positive and negative affect may influence creativity in IBMT group (not RT group).
Conclusions
Our results suggested that emotion-related creativity-promoting mechanism may be attributed to short-term meditation.
doi:10.1186/1744-9081-10-9
PMCID: PMC3994657  PMID: 24645871
Creativity; Emotion; Positive affect; Negative affect; Short-term meditation; Integrative body-mind training; Cross-lagged analysis
3.  Motivational Salience Signal in the Basal Forebrain Is Coupled with Faster and More Precise Decision Speed 
PLoS Biology  2014;12(3):e1001811.
Avila and Lin report that the speed and variability of the decision-making process are tightly coupled and jointly determined by the motivational salience signal in the basal forebrain.
The survival of animals depends critically on prioritizing responses to motivationally salient stimuli. While it is generally believed that motivational salience increases decision speed, the quantitative relationship between motivational salience and decision speed, measured by reaction time (RT), remains unclear. Here we show that the neural correlate of motivational salience in the basal forebrain (BF), defined independently of RT, is coupled with faster and also more precise decision speed. In rats performing a reward-biased simple RT task, motivational salience was encoded by BF bursting response that occurred before RT. We found that faster RTs were tightly coupled with stronger BF motivational salience signals. Furthermore, the fraction of RT variability reflecting the contribution of intrinsic noise in the decision-making process was actively suppressed in faster RT distributions with stronger BF motivational salience signals. Artificially augmenting the BF motivational salience signal via electrical stimulation led to faster and more precise RTs and supports a causal relationship. Together, these results not only describe for the first time, to our knowledge, the quantitative relationship between motivational salience and faster decision speed, they also reveal the quantitative coupling relationship between motivational salience and more precise RT. Our results further establish the existence of an early and previously unrecognized step in the decision-making process that determines both the RT speed and variability of the entire decision-making process and suggest that this novel decision step is dictated largely by the BF motivational salience signal. Finally, our study raises the hypothesis that the dysregulation of decision speed in conditions such as depression, schizophrenia, and cognitive aging may result from the functional impairment of the motivational salience signal encoded by the poorly understood noncholinergic BF neurons.
Author Summary
Humans and animals face the constant challenge of identifying the subset of incoming sensory stimuli that are most behaviorally relevant and prioritizing behavioral responses accordingly. Critical to this decision is the ability to determine whether a stimulus is motivationally salient—that is, whether the stimulus predicts important behavioral outcomes such as reward or punishment. While it is generally assumed that motivational salience is related to faster decision speed and shorter reaction time, it remains unclear how motivational salience actually modulates the decision-making process. This study investigates how the motivational salience signal in the basal forebrain controls the fundamental properties of the decision-making process—decision speed and its variability. In rats performing a reward-biased simple reaction time task, we show that the basal forebrain motivational salience signal is associated with a faster and also precise decision speed. In support of a causal role for this association, artificially augmenting this basal forebrain motivational salience signal by electrical stimulation also leads to faster and more precise reaction times. These results suggest that decision speed and its variability are jointly determined by an early and previously unrecognized step in the decision-making process, dictated largely by the motivational salience signal encoded by poorly understood noncholinergic neurons in the basal forebrain.
doi:10.1371/journal.pbio.1001811
PMCID: PMC3958335  PMID: 24642480
4.  Special issue on mindfulness neuroscience 
doi:10.1093/scan/nss104
PMCID: PMC3541496  PMID: 22956677
5.  Tools of the trade: theory and method in mindfulness neuroscience 
Mindfulness neuroscience is an emerging research field that investigates the underlying mechanisms of different mindfulness practices, different stages and different states of practice as well as different effects of practice over the lifespan. Mindfulness neuroscience research integrates theory and methods from eastern contemplative traditions, western psychology and neuroscience, and from neuroimaging techniques, physiological measures and behavioral tests. We here review several key theoretical and methodological challenges in the empirical study of mindfulness neuroscience and provide suggestions for overcoming these challenges.
doi:10.1093/scan/nss112
PMCID: PMC3541497  PMID: 23081977
mindfulness neuroscience; mindfulness; meditation; neuroplasticity; gene-environment interaction
6.  The Dopamine Receptor D4 Gene 7-Repeat Allele Interacts with Parenting Quality to Predict Effortful Control in Four-Year-Old Children 
Child development research  2012;2012:863242-.
The dopamine receptor D4 gene (DRD4) 7-repeat allele has been found to interact with environmental factors such as parenting in children and peer attitudes in adults to influence aspects of behavior such as risk taking. We previously found that in toddlers, lower-quality parenting in combination with the 7-repeat allele of the DRD4 gene was associated with greater parent-reported Sensation Seeking (SS), but was unrelated to Effortful Control (EC). We now report findings from a followup assessment with the same sample of children showing that parenting quality interacts with the presence of the 7-repeat allele to predict EC in 3-to 4-year-old children. The change in these patterns of results may reflect the increased role of the executive attention network in older children and adults. However, due to the small sample size (N = 52) and the novelty of the results, these findings should be treated with caution and considered preliminary until they are replicated in an independent sample.
doi:10.1155/2012/863242
PMCID: PMC3712539  PMID: 23869253
7.  IMAGING ATTENTION NETWORKS1 
Neuroimage  2011;61(2):450-456.
The study of attention has largely been about how to select among the various sensory events but also involves the selection among conflicting actions. Prior to the late 1980s, locating bottlenecks between sensory input and response dominated these studies, a different view was that attentional limits involved the importance of maintaining behavioral coherence rather than resulting from a bottleneck. In both cases ideas of resource limits taken over from economics were important. Early evidence relating to the anatomy of attention came from neurological investigations of lesioned patients, but the major impetus for the anatomical approach came from neuroimaging studies that provided evidence of brain networks related to orienting to sensory events and control of response tendencies. The presence of a functional anatomy has supported studies of the development of attention networks and the role of neuromodulators and genetic poymorphisms in their construction. Together these developments have enhanced our understanding of attention and paved the way for significant applications to education, pathology and prevention of mental illness.
doi:10.1016/j.neuroimage.2011.12.040
PMCID: PMC3345293  PMID: 22227132
8.  Neural correlates of establishing, maintaining, and switching brain states 
Trends in cognitive sciences  2012;16(6):330-337.
Although the study of brain states is an old one in neuroscience, there has been growing interest in brain state specification owing to MRI studies tracing brain connectivity at rest. In this review, we summarize recent research on three relatively well-described brain states: the resting, alert, and meditation states. We explore the neural correlates of maintaining a state or switching between states, and argue that the anterior cingulate cortex and striatum play a critical role in state maintenance, whereas the insula has a major role in switching between states. Brain state may serve as a predictor of performance in a variety of perceptual, memory, and problem solving tasks. Thus, understanding brain states is critical for understanding human performance.
doi:10.1016/j.tics.2012.05.001
PMCID: PMC3419378  PMID: 22613871
9.  Control Networks and Neuromodulators of Early Development1 
Developmental Psychology  2011;48(3):827-835.
In adults most cognitive and emotional self-regulation is carried out by a network of brain regions, including the anterior cingulate, insula and areas of the basal ganglia, related to executive attention. We propose that during infancy control systems depend primarily upon a brain network involved in orienting to sensory events that includes areas of the parietal lobe and frontal eye fields. Studies of human adults and alert monkeys show that the brain network involved in orienting to sensory events is moderated primarily by the nicotinic cholinergic system arising in the nucleus basalis. The executive attention network is primarily moderated by dopaminergic input from the ventral tegmental area. A change from cholinergic to dopaminergic modulation would be a consequence of this switch of control networks and may be important in understanding early development. We trace the attentional, emotional and behavioral changes in early development related to this developmental change in regulative networks and their modulators.
doi:10.1037/a0025530
PMCID: PMC3253251  PMID: 21942663
10.  Neural Activity during Natural Viewing of Sesame Street Statistically Predicts Test Scores in Early Childhood 
PLoS Biology  2013;11(1):e1001462.
Neural activity that is evoked naturalistically in children during educational television viewing can be used to predict math and verbal knowledge.
It is not currently possible to measure the real-world thought process that a child has while observing an actual school lesson. However, if it could be done, children's neural processes would presumably be predictive of what they know. Such neural measures would shed new light on children's real-world thought. Toward that goal, this study examines neural processes that are evoked naturalistically, during educational television viewing. Children and adults all watched the same Sesame Street video during functional magnetic resonance imaging (fMRI). Whole-brain intersubject correlations between the neural timeseries from each child and a group of adults were used to derive maps of “neural maturity” for children. Neural maturity in the intraparietal sulcus (IPS), a region with a known role in basic numerical cognition, predicted children's formal mathematics abilities. In contrast, neural maturity in Broca's area correlated with children's verbal abilities, consistent with prior language research. Our data show that children's neural responses while watching complex real-world stimuli predict their cognitive abilities in a content-specific manner. This more ecologically natural paradigm, combined with the novel measure of “neural maturity,” provides a new method for studying real-world mathematics development in the brain.
Author Summary
In the real world, children learn new information by participating in classrooms, interacting with their family and friends, and watching educational videos. While previous neuroimaging research has typically used simple tasks and short-lasting stimuli, in this study we examined brain development using a more complex and naturalistic educational stimulus. Children and adults all watched the same Sesame Street video as we measured their neural activity using functional magnetic resonance imaging (fMRI). We examined the timecourses of neural activity over the length of the video for children and adults. We found that the degree to which children showed adult-like brain responses was correlated with their math and verbal knowledge levels. In the intraparietal sulcus, children's neural correlation with adults depended on their mathematics knowledge whereas in Broca's area, it depended on their verbal knowledge. Additional experiments showed that children's neural responses in the intraparietal sulcus are selectively driven by numerical content both when children are watching Sesame Street and when they engage in a number matching task. These convergent results highlight the broad role of the intraparietal sulcus in processing numerical information. In addition, our study validates the use of naturalistic stimuli and child-to-adult neural timecourse correlations for studying brain development. We suggest that this new approach can enrich our understanding of how children's brains process information in the real world.
doi:10.1371/journal.pbio.1001462
PMCID: PMC3536813  PMID: 23300385
11.  A Definitive Volume on Temperament 
doi:10.3389/fpsyg.2012.00332
PMCID: PMC3445045
12.  Expanding horizons in ergonomics research 
NeuroImage  2011;59(1):149-153.
doi:10.1016/j.neuroimage.2011.07.060
PMCID: PMC3413260  PMID: 21816226
13.  The Attention System of the Human Brain: 20 Years After 
Here, we update our 1990 Annual Review of Neuroscience article, “The Attention System of the Human Brain.” The framework presented in the original article has helped to integrate behavioral, systems, cellular, and molecular approaches to common problems in attention research. Our framework has been both elaborated and expanded in subsequent years. Research on orienting and executive functions has supported the addition of new networks of brain regions. Developmental studies have shown important changes in control systems between infancy and childhood. In some cases, evidence has supported the role of specific genetic variations, often in conjunction with experience, that account for some of the individual differences in the efficiency of attentional networks. The findings have led to increased understanding of aspects of pathology and to some new interventions.
doi:10.1146/annurev-neuro-062111-150525
PMCID: PMC3413263  PMID: 22524787
alerting network; executive network; orienting network; cingulo-opercular network; frontoparietal network
14.  Attentional Networks and Consciousness 
The term consciousness is an important one in the vernacular of the western literature in many fields. It is no wonder that scientists have assumed that consciousness will be found as a component of the human brain and that we will come to understand its neural basis. However, there is rather little in common between consciousness as the neurologist would use it to diagnose the vegetative state, how the feminist would use it to support raising male consciousness of the economic plight of women and as the philosopher would use it when defining the really hard question of the subjective state of awareness induced by sensory qualities. When faced with this kind of problem it is usual to subdivide the term into more manageable perhaps partly operational definitions. Three meanings that capture aspects of consciousness are: (1) the neurology of the state of mind allowing coherent orientation to time and place (2) the selection of sensory or memorial information for awareness and (3) the voluntary control over overt responses. In each of these cases the mechanisms of consciousness overlap with one or more of the attentional networks that have been studied with the methods of cognitive neuroscience. In this paper we explore the overlap and discuss how to exploit the growing knowledge of attentional networks to constrain ideas of consciousness.
doi:10.3389/fpsyg.2012.00064
PMCID: PMC3298960  PMID: 22416239
attention networks; alerting; orienting; executive
15.  The impact of poverty on the development of brain networks 
Although the study of brain development in non-human animals is an old one, recent imaging methods have allowed non-invasive studies of the gray and white matter of the human brain over the lifespan. Classic animal studies show clearly that impoverished environments reduce cortical gray matter in relation to complex environments and cognitive and imaging studies in humans suggest which networks may be most influenced by poverty. Studies have been clear in showing the plasticity of many brain systems, but whether sensitivity to learning differs over the lifespan and for which networks is still unclear. A major task for current research is a successful integration of these methods to understand how development and learning shape the neural networks underlying achievements in literacy, numeracy, and attention. This paper seeks to foster further integration by reviewing the current state of knowledge relating brain changes to behavior and indicating possible future directions.
doi:10.3389/fnhum.2012.00238
PMCID: PMC3421156  PMID: 22912613
childhood poverty; brain networks; plasticity; attention; literacy; numeracy
16.  Cigarette Smoking and Alcohol Use among Adolescents and Young Adults with Asthma 
Nursing Research and Practice  2011;2011:503201.
Asthma is one of the most common, serious chronic diseases in pediatric and young adult populations. Health-risk behaviors, including cigarette smoking and alcohol use, may exacerbate chronic diseases and complicate their management. The aim of this study was to longitudinally analyze rates of cigarette smoking and alcohol use in adolescents and young adults who have asthma and those who do not have asthma. A secondary analysis of data from the National Longitudinal Study of Adolescent Health was undertaken. Individuals with asthma were found to exhibit increasing rates of cigarette smoking and alcohol use as they aged. When an adolescent with a chronic health issue begins health-risk-taking behaviors, behavior change interventions must be planned. Pediatric nurses, practitioners, and clinicians are uniquely positioned to assess for health-risk behaviors in youth with asthma and to intervene with plans of care that are tailored for the needs of this vulnerable population.
doi:10.1155/2011/503201
PMCID: PMC3246743  PMID: 22220272
17.  How Awareness Changes the Relative Weights of Evidence During Human Decision-Making 
PLoS Biology  2011;9(11):e1001203.
A combined behavioral and brain imaging study shows how sensory awareness and stimulus visibility can influence the dynamics of decision-making in humans.
Human decisions are based on accumulating evidence over time for different options. Here we ask a simple question: How is the accumulation of evidence affected by the level of awareness of the information? We examined the influence of awareness on decision-making using combined behavioral methods and magneto-encephalography (MEG). Participants were required to make decisions by accumulating evidence over a series of visually presented arrow stimuli whose visibility was modulated by masking. Behavioral results showed that participants could accumulate evidence under both high and low visibility. However, a top-down strategic modulation of the flow of incoming evidence was only present for stimuli with high visibility: once enough evidence had been accrued, participants strategically reduced the impact of new incoming stimuli. Also, decision-making speed and confidence were strongly modulated by the strength of the evidence for high-visible but not low-visible evidence, even though direct priming effects were identical for both types of stimuli. Neural recordings revealed that, while initial perceptual processing was independent of visibility, there was stronger top-down amplification for stimuli with high visibility than low visibility. Furthermore, neural markers of evidence accumulation over occipito-parietal cortex showed a strategic bias only for highly visible sensory information, speeding up processing and reducing neural computations related to the decision process. Our results indicate that the level of awareness of information changes decision-making: while accumulation of evidence already exists under low visibility conditions, high visibility allows evidence to be accumulated up to a higher level, leading to important strategical top-down changes in decision-making. Our results therefore suggest a potential role of awareness in deploying flexible strategies for biasing information acquisition in line with one's expectations and goals.
Author Summary
When making a decision, we gather evidence for the different options and ultimately choose on the basis of the accumulated evidence. A fundamental question is whether and how conscious awareness of the evidence changes this decision-making process. Here, we examined the influence of sensory awareness on decision-making using behavioral studies and magneto-encephalographic recordings in human participants. In our task, participants had to indicate the prevailing direction of five arrows presented on a screen that each pointed either left or right, and in different trials these arrows were either easy to see (high visibility) or difficult to see (low visibility). Behavioral and neural recordings show that evidence accumulation changed from a linear to a non-linear integration strategy with increasing stimulus visibility. In particular, the impact of later evidence was reduced when more evidence had been accrued, but only for highly visible information. By contrast, barely perceptible arrows contributed equally to a decision because participants needed to continue to accumulate evidence in order to make an accurate decision. These results suggest that consciousness may play a role in decision-making by biasing the accumulation of new evidence.
doi:10.1371/journal.pbio.1001203
PMCID: PMC3222633  PMID: 22131904
18.  Developing Mechanisms of Self-Regulation in Early Life 
Emotion review  2011;3(2):207-213.
Children show increasing control of emotions and behavior during their early years. Our studies suggest a shift in control from the brain's orienting network in infancy to the executive network by the age of 3–4 years. Our longitudinal study indicates that orienting influences both positive and negative affect, as measured by parent report in infancy. At 3–4 years of age, the dominant control of affect rests in a frontal brain network that involves the anterior cingulate gyrus. Connectivity of brain structures also changes from infancy to toddlerhood. Early connectivity of parietal and frontal areas is important in orienting; later connectivity involves midfrontal and anterior cingulate areas related to executive attention and self-regulation.
doi:10.1177/1754073910387943
PMCID: PMC3164871  PMID: 21892360
attention; connectivity; development; orienting
19.  Brain states and hypnosis research✩,✩✩ 
Consciousness and cognition  2010;20(2):325-327.
Research in cognitive neuroscience now considers the state of the brain prior to the task an important aspect of performance. Hypnosis seems to alter the brain state in a way which allows external input to dominate over internal goals. We examine how normal development may illuminate the hypnotic state.
doi:10.1016/j.concog.2009.11.008
PMCID: PMC3164825  PMID: 20060745
20.  Variations in COMT Gene Interact With Parenting to Influence Attention in Early Development1 
Neuroscience  2009;164(1):121-130.
Attention influences many aspects of cognitive development. Variations in the COMT gene, known to affect dopamine neurotransmission, have frequently been found to influence attention in adults and older children. In this paper we examined 2 year old children and found that variation in the COMT gene influenced attention in a task involving looking to a sequence of visual stimuli. Because the influence of another dopamine related gene (DRD4) has been shown to interact with parenting quality at this age, we explored parenting in relation to variations in the COMT gene. Variations in COMT interacted with parenting quality to influence our attention measure. The Val108/158Met polymorphism of COMT is commonly used to determine allelic groups, but recently haplotypes of several polymorphisms within this gene have been shown to do a better job in reflecting perceived pain. Since attention and pain both involve the activation of the anterior cingulate gyrus in imaging studies, we compared the Val108/158Met influence with the COMT haplotypes and found the latter to be more predictive of attention. Our results confirm that important aspects of cognitive development including attention depend on the interaction of genes and early environment.
doi:10.1016/j.neuroscience.2009.05.059
PMCID: PMC2760680  PMID: 19482061
21.  Testing the behavioral interaction and integration of attentional networks 
Brain and cognition  2009;70(2):209-220.
One current conceptualization of attention subdivides it into functions of alerting, orienting, and executive control. Alerting describes the function of tonically maintaining the alert state and phasically responding to a warning signal. Automatic and voluntary orienting are involved in the selection of information among multiple sensory inputs. Executive control describes a set of more complex operations that includes monitoring and resolving conflicts in order to control thoughts or behaviors. Converging evidence supports this theory of attention by showing that each function appears to be subserved by anatomically distinct networks in the brain and differentially innervated by various neuromodulatory systems. Although much research has been dedicated to understanding the functional separation of these networks in both healthy and disease states, the interaction and integration among these networks still remain unclear. In this study, we aimed to characterize possible behavioral interaction and integration in healthy adult volunteers using a revised attentional network test (ANT-R) with cue-target interval and cue validity manipulations. We found that whereas alerting improves overall response speed, it exerts negative influence on executive control under certain conditions. A valid orienting cue enhances but an invalid cue diminishes the ability of executive control to overcome conflict. The results support the hypothesis of functional integration and interaction of these brain networks.
doi:10.1016/j.bandc.2009.02.002
PMCID: PMC2674119  PMID: 19269079
attention; attentional networks; alerting; orienting; executive control
22.  Toward A Physical Basis of Attention and Self Regulation1 
Physics of life reviews  2009;6(2):103-120.
The concept of self-regulation is central to the understanding of human development. Self-regulation allows effective socialization and predicts both psychological pathologies and levels of achievement in schools. What has been missing are neural mechanisms to provide understanding of the cellular and molecular basis for self-regulation. We show that self-regulation can be measured during childhood by parental reports and by self-reports of adolescents and adults. These reports are summarized by a higher order factor called effortful control, which reflects perceptions about the ability of a given person to regulate their behavior in accord with cultural norms. Throughout childhood effortful control is related to children’s performance in computerized conflict related tasks. Conflict tasks have been shown in neuroimaging studies to activate specific brain networks of executive attention. Several brain areas work together at rest and during cognitive tasks to regulate competing brain activity and thus control resulting behavior. The cellular structure of the anterior cingulate and insula contain cells, unique to humans and higher primates that provide strong links to remote brain areas. During conflict tasks, anterior cingulate activity is correlated with activity in remote sensory and emotional systems, depending upon the information selected for the task. During adolescence the structure and activity of the anterior cingulate has been found to be correlated with self-reports of effortful control.
Studies have provided a perspective on how genes and environment act to shape the executive attention network, providing a physical basis for self-regulation. The anterior cingulate is regulated by dopamine. Genes that influence dopamine levels in the CNS have been shown to influence the efficiency of self-regulation. For example, alleles of the COMT gene that influence the efficiency of dopamine transmission are related to the ability to resolve conflict. Humans with disorders involving deletion of this gene exhibit large deficits in self-regulation. Alleles of other genes influencing dopamine and serotonin transmission have also been found to influence ability to resolve conflict in cognitive tasks. However, as is the case for many genes, the effectiveness of COMT alleles in shaping self-regulation depends upon cultural influences such as parenting. Studies find that aspects of parenting quality and parent training can influence child behavior and the efficiency of self-regulation.
During development, the network that relates to self-regulation undergoes important changes in connectivity. Infants can use parts of the self-regulatory network to detect errors in sensory information, but the network does not yet have sufficient connectivity to organize brain activity in a coherent way. During middle childhood, along with increased projection cells involved in remote connections of dorsal anterior cingulate and prefrontal and parietal cortex, executive network connectivity increases and shifts from predominantly short to longer range connections. During this period specific exercises can influence network development and improve self-regulation. Understanding the physical basis of self-regulation has already cast light on individual differences in normal and pathological states and gives promise of allowing the design of methods to improve aspects of human development.
doi:10.1016/j.plrev.2009.02.001
PMCID: PMC2748943  PMID: 20161073
Attention; genetic alleles; neural networks; self-regulation
23.  Post-Hospital Medical Respite Care and Hospital Readmission of Homeless Persons 
Medical respite programs offer medical, nursing, and other care as well as accommodation for homeless persons discharged from acute hospital stays. They represent a community-based adaptation of urban health systems to the specific needs of homeless persons. This paper examines whether post-hospital discharge to a homeless medical respite program was associated with a reduced chance of 90-day readmission compared to other disposition options. Adjusting for imbalances in patient characteristics using propensity scores, Respite patients were the only group that was significantly less likely to be readmitted within 90 days compared to those released to Own Care. Respite programs merit attention as a potentially efficacious service for homeless persons leaving the hospital.
doi:10.1080/10852350902735734
PMCID: PMC2702998  PMID: 19363773
homeless; readmission; retrospective studies; discharge planning; health services
24.  Provisional hypotheses for the molecular genetics of cognitive development: Imaging genetic pathways in the anterior cingulate cortex 
Biological psychology  2007;79(1):23-29.
Brain imaging genetic research involves a multitude of methods and spans many traditional levels of analysis. Given the vast permutations among several million common genetic variants with thousands of brain tissue voxels and a wide array of cognitive tasks that activate specific brain systems, we are prompted to develop specific hypotheses that synthesize converging evidence and state clear predictions about the anatomical sources, magnitude and direction (increases vs. decreases) of allele- and task-specific brain activity associations. To begin to develop a framework for shaping our imaging genetic hypotheses, we focus on previous results and the wider imaging genetic literature. Particular emphasis is placed on converging evidence that links system-level and biochemical studies with models of synaptic function. In shaping our own imaging genetic hypotheses on the development of Attention Networks, we review relevant literature on core models of synaptic physiology and development in the anterior cingulate cortex.
doi:10.1016/j.biopsycho.2007.12.006
PMCID: PMC2570040  PMID: 18261834
25.  Children Who Witness Violence, and Parent Report of Children’s Behavior 
Objectives
To examine how much distress children report in response to violence that they have witnessed and how this is associated with parental reports of children’s behavior.
Methods
As part of a study of in utero exposure to cocaine, children completed the Levonn interview for assessing children’s symptoms of distress in response to witnessing violence. The children’s care givers completed the Exposure to Violence Interview (EVI), a caretaker-report measure of the child’s exposure to violent events during the last 12 months. The EVI was analyzed as a 3-level variable: no exposure, low exposure, and high exposure. The caregivers also completed the Children’s Behavior Checklist (CBCL).
Results
Of 94 six-year-old children, 58% had no exposure to violence, 36% had low exposure to violence, and 6% had high exposure to violence, according to caretaker reports. The children’s median ±SD Levonn score was 64 (SD ± 19.3). The mean (SD ± CBCL total T-score was 53 (SD ± 10.2). In multiple regression analyses with gender, low and high exposure on EVI, Levonn, and prenatal cocaine exposure status as predictors, the Levonn score explained 4.8% of total variance in children’s CBCL internalizing scores, 9.1% of the total variance in CBCL externalizing score, and 12.2% of the total variance in CBCL total score (P = .04, P = .004, and P <.001, respectively).
Conclusions
After accounting for the caretaker’s report of the level of the child’s exposure to violence, the child’s own report significantly increased the amount of variance in predicting child behavior problems with the CBCL. These findings indicate that clinicians and researchers should elicit children’s own accounts of exposure to violence in addition to the caretakers’ when attempting to understand children’s behavior.
PMCID: PMC2366171  PMID: 12144371

Results 1-25 (36)