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1.  Inferring Passenger Denial Behavior of Taxi Drivers from Large-Scale Taxi Traces 
PLoS ONE  2016;11(11):e0165597.
How to understand individual human actions is a fundamental question to modern science, which drives and incurs many social, technological, racial, religious and economic phenomena. Human dynamics tries to reveal the temporal pattern and internal mechanism of human actions in letter or electronic communications, from the perspective of continuous interactions among friends or acquaintances. For interactions between stranger to stranger, taxi industry provide fruitful phenomina and evidence to investigate the action decisions. In fact, one striking disturbing events commonly reported in taxi industry is passenger refusing or denial, whose reasons vary, including skin color, blind passenger, being a foreigner or too close destination, religion reasons and anti specific nationality, so that complaints about taxi passenger refusing have to be concerned and processed carefully by local governments. But more universal factors for this phenomena are of great significance, which might be fulfilled by big data research to obtain novel insights in this question. In this paper, we demonstrate the big data analytics application in revealing novel insights from massive taxi trace data, which, for the first time, validates the passengers denial in taxi industry and estimates the denial ratio in Beijing city. We first quantify the income differentiation facts among taxi drivers. Then we find out that choosing the drop-off places also contributes to the high income for taxi drivers, compared to the previous explanation of mobility intelligence. Moreover, we propose the pick-up, drop-off and grid diversity concepts and related diversity analysis suggest that, high income taxi drivers will deny passengers in some situations, so as to choose the passengers’ destination they prefer. Finally we design an estimation method for denial ratio and infer that high income taxi drivers will deny passengers with 8.52% likelihood in Beijing. Our work exhibits the power of big data analysis in revealing some dark side investigation.
doi:10.1371/journal.pone.0165597
PMCID: PMC5094781  PMID: 27812121
2.  Treatment of major depressive disorders with generic duloxetine and paroxetine: a multi-centered, double-blind, double-dummy, randomized controlled clinical trial 
Shanghai Archives of Psychiatry  2015;27(4):228-236.
Background
This study is a pre-registration trial of generic duloxetine that was approved by the China Food and Drug Administration (approval number: 2006L01603).
Aims
Compare the treatment efficacy and safety of generic duloxetine to that of paroxetine in patients with major depressive disorders (MDD).
Methods
This was a double-dummy, double-blind, multicenter, positive drug (paroxetine), parallel randomized controlled clinical trial. The 299 patients with MDD recruited for the study were randomly assigned to use duloxetine (n=149; 40–60 mg/d) or paroxetine (n=150; 20 mg/d) for 8 weeks. The Hamilton Depression rating scale (HAMD-17) was administered at baseline and 1, 2, 4, 6, and 8 weeks after starting treatment. Remission was defined as a HAMD-17 score below 8 at the end of the trial, and treatment effectiveness was defined as a decrease in baseline HAMD-17 score of at least 50% by the end of the trial. Safety was assessed based on the reported prevalence and severity of side effects and changes in laboratory and electrocardiographic findings. Three patients in the duloxetine group dropped out before starting medication, so results were analyzed using a modified intention-to-treat (ITT) method with 146 in the experimental group and 150 in the control group.
Results
Both groups experienced 29 dropouts during the 8-week trial. HAMD-17 scores decreased significantly from baseline throughout the trial in both groups. Based on the ITT analysis, at the end of the trial there was no significant difference between the duloxetine group and the paroxetine group in effectiveness (67.1% v. 71.3%, X2=0.62 p=0.433), remission rate (41.1% v. 51.3%, X2=3.12, p=0.077), or in the incidence of side effects (56.8% v. 54.7%, X2=0.14, p=0.705).
Conclusions
Generic duloxetine is as effective and safe as paroxetine in the acute treatment of patients with MDD who seek care at psychiatric outpatient departments in China.
doi:10.11919/j.issn.1002-0829.215064
PMCID: PMC4621288  PMID: 26549959
duloxetine; paroxetine; efficacy; safety; major depressive disorder; randomized controlled trial; China
3.  Resemblance of Symptoms for Major Depression Assessed at Interview versus from Hospital Record Review 
PLoS ONE  2012;7(1):e28734.
Background
Diagnostic information for psychiatric research often depends on both clinical interviews and medical records. Although discrepancies between these two sources are well known, there have been few studies into the degree and origins of inconsistencies.
Principal findings
We compared data from structured interviews and medical records on 1,970 Han Chinese women with recurrent DSM-IV major depression (MD). Correlations were high for age at onset of MD (0.93) and number of episodes (0.70), intermediate for family history (+0.62) and duration of longest episode (+0.43) and variable but generally more modest for individual depressive symptoms (mean kappa = 0.32). Four factors were identified for twelve symptoms from medical records and the same four factors emerged from analysis of structured interviews. Factor congruencies were high but the correlation of factors between interviews and records were modest (i.e. +0.2 to +0.4).
Conclusions
Structured interviews and medical records are highly concordant for age of onset, and the number and length of episodes, but agree more modestly for individual symptoms and symptom factors. The modesty of these correlations probably arises from multiple factors including i) inconsistency in the definition of the worst episode, ii) inaccuracies in self-report and iii) difficulties in coding medical records where symptoms were recorded solely for clinical purposes.
doi:10.1371/journal.pone.0028734
PMCID: PMC3256142  PMID: 22247760
4.  Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women☆ 
Journal of Affective Disorders  2011;135(1-3):95-99.
Background
In European and US studies, patients with major depressive disorder (MDD) report more stressful life events (SLEs) than controls, but this relationship has rarely been studied in Chinese populations.
Methods
Sixteen lifetime SLEs were assessed at interview in two groups of Han Chinese women: 1970 clinically ascertained with recurrent MDD and 2597 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression.
Results
60% of controls and 72% of cases reported at least one lifetime SLE. Fourteen of the sixteen SLEs occurred significantly more frequently in those with MDD (median odds ratio of 1.6). The three SLEs most strongly associated with risk for MDD (OR > 3.0) preceded the onset of MDD the majority of the time: rape (82%), physical abuse (100%) and serious neglect (99%).
Limitations
Our results may apply to females only. SLEs were rated retrospectively and are subject to biases in recollection. We did not assess contextual information for each life event.
Conclusions
More severe SLEs are more strongly associated with MDD. These results support the involvement of psychosocial adversity in the etiology of MDD in China.
doi:10.1016/j.jad.2011.06.054
PMCID: PMC3210899  PMID: 21821294
Major depressive disorder; Stressful life event; Social adversity; Symptom

Results 1-4 (4)