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1.  Crystal structure of dimethyl 3,3′-[(3-fluoro­phenyl)methyl­ene]bis­(1H-indole-2-carboxyl­ate) 
In the title compound, the two indole ring systems are approximately perpendicular to one another, making a dihedral angle of 87.8 (5)°. In the crystal, pairs of N—H⋯O hydrogen bonds link the mol­ecules into the inversion dimers, which are further linked by N—H⋯O hydrogen bonds into supra­molecular chains propagating along the b-axis direction.
In the title compound, C27H21FN2O4, the mean planes of the two indole ring systems (r.m.s. deviations = 0.0166 and 0.0086 Å) are approximately perpendic­ular to one another, making a dihedral angle of 87.8 (5)°; the fluorobenzene ring is twisted with respect to the mean planes of the two indole ring systems at 82.7 (5) and 85.5 (3)°. In the crystal, pairs of N—H⋯O hydrogen bonds link the mol­ecules into the inversion dimers, which are further linked by N—H⋯O hydrogen bonds into supra­molecular chains propagating along the b-axis direction. Weak C—H⋯π inter­actions are observed between neighbouring chains.
doi:10.1107/S1600536814025756
PMCID: PMC4257463  PMID: 25553001
crystal structure; indole; MRI contrast agent; N—H⋯O hydrogen bonds; C—H⋯π inter­actions
2.  Crystal structure of dimethyl 3,3′-[(3-nitro­phen­yl)methyl­ene]bis­(1H-indole-2-carboxyl­ate) ethanol monosolvate 
In the title compound, the planes of the two indole ring systems are approximately perpendicular to each other, with a dihedral angle of 89.3 (5)°.
In the title compound, C27H21N3O6·C2H5OH, the indole ring systems are approximately perpendicular to each other, with a dihedral angle of 89.3 (5)°; the plane of the benzene ring is oriented with respect to the indole ring systems at 49.9 (5) and 73.4 (3)°. In the crystal, mol­ecules are linked by N—H⋯O and O—H⋯O hydrogen bonds and weak C—H⋯π inter­actions into a three-dimensional supra­molecular architecture. A void of 33.0 (7) Å3 is observed in the crystal structure. The solvent ethanol molecule acts as a donor, forming an O—H⋯O hydrogen bond, reinforcing the framework structure.
doi:10.1107/S1600536814022296
PMCID: PMC4257280  PMID: 25484748
indole; crystal structure; MRI contrast agent
3.  Crystal structure of dimethyl 3,3′-[(4-chloro­phen­yl)methyl­ene]bis­(1H-indole-2-carboxyl­ate) 
In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds, forming inversion dimers, which are linked by a further N—H⋯O hydrogen bond, forming chains along [100]. There are intra- and inter­molecular C—H⋯π inter­actions present, the latter linking the chains to form a three-dimensional supra­molecular structure.
In the title compound, C27H21ClN2O4, the mean planes of the two indole ring systems (r.m.s. deviations = 0.021 and 0.024 Å) are approximately perpendicular to one another, with a dihedral angle of 79.54 (12)°. The benzene ring is twisted with respect to the mean planes of the two indole ring systems at angles of 80.14 (15) and 86.30 (15)°. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds, forming inversion dimers with an R 2 2(18) ring motif. The dimers are linked by a further N—H⋯O hydrogen bond, forming chains along [100]. There are intra- and inter­molecular C—H⋯π inter­actions present, the latter linking the chains to form a three-dimensional supra­molecular structure.
doi:10.1107/S1600536814020686
PMCID: PMC4257187  PMID: 25484668
crystal structure; indole; bis-indolymethane; MRI contrast agent; N—H⋯O hydrogen bonds; C—H⋯π inter­actions
4.  2-(1-Benzo­thio­phen-2-yl)-4H-1,3,4-oxa­diazin-5(6H)-one 
In the title compound, C11H8N2O2S, the oxadiazinone ring is nearly planar [maximum deviation = 0.016 (4) Å], and is approximately coplanar with the benzo­thio­phene ring system [dihedral angle = 3.1 (5)°]. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds, forming chains running along the b-axis direction.
doi:10.1107/S1600536813033291
PMCID: PMC3914084  PMID: 24526987
5.  Dimethyl 3,3′-(phenyl­methyl­ene)bis­(1H-indole-2-carboxyl­ate) 
In the title compound, C27H22N2O4, the two indole ring systems are approximately perpendicular to each other, with a dihedral angle of 84.5 (5)° between their planes; the benzene ring is twisted with respect to the two indole ring systems at angles of 78.5 (5) and 86.5 (3)°. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds, weak C—H⋯O and C—H⋯N hydrogen bonds, and C—H⋯π inter­actions into a three-dimensional supra­molecular architecture.
doi:10.1107/S1600536813024471
PMCID: PMC3790385  PMID: 24098207
6.  3-Chloro-2,4,5-trifluoro­benzoic acid 
The title compound, C7H2ClF3O2, was prepared by the chlorination of 3-amino-2,4,5-trifluoro­benzoic acid. The carboxyl group is twisted relative to the benzene ring by 6.8 (1)°. In the crystal, pairs of O—H⋯O hydrogen bonds link mol­ecules into typical centrosymmetric carb­oxy­lic acid dimers. These dimers are arranged into sheets parallel to (-103).
doi:10.1107/S1600536812049446
PMCID: PMC3588316  PMID: 23476418
7.  N-[(2S)-2-Chloro­propano­yl]glycine 
The title compound, C5H8ClNO3, was prepared by the nucleophilic substitution reaction of (2S)-2-chloro­propanoyl chloride with glycine. The acetate group forms a dihedral angle of 84.6 (1)° with the mean plane of the C—NH—C=O fragment. In the crystal, the molecules are linked by N—H⋯O and O—H⋯O hydrogen bonds, generating a three-dimensional network, which consolidates the crystal packing.
doi:10.1107/S1600536812036720
PMCID: PMC3435838  PMID: 22969684
8.  Diethyl 3,3′-(phenyl­methyl­ene)bis­(1H-indole-2-carboxyl­ate) 
In the title compound, C29H26N2O4, the benzene ring is twisted by 73.5 (5) and 84.9 (3)° with respect to the mean planes of the two indole ring systems; the mean planes of the indole ring systems are oriented at a dihedral angle of 82.0 (5)°. In the crystal, mol­ecules are linked by pairs of N—H⋯O hydrogen bonds into chains.
doi:10.1107/S1600536812036239
PMCID: PMC3435799  PMID: 22969645
9.  N-[4-(4-Fluoro­phen­yl)-5-hy­droxy­methyl-6-isopropyl­pyrimidin-2-yl]-N-methyl­methane­sulfonamide 
In the title compound, C16H20FN3O3S, the pyrimidine and benzene rings are oriented at a dihedral angle of 38.8 (3)°. An intra­molecular C—H⋯O hydrogen bond occurs. The crystal structure is stabilized by O—H⋯N hydrogen bonds. In addition, C—H⋯O inter­actions are also present.
doi:10.1107/S1600536811049051
PMCID: PMC3239065  PMID: 22199913
10.  Ethyl 8-chloro-1-cyclo­propyl-6,7-difluoro-4-oxo-1,4-dihydro­quinoline-3-carboxyl­ate 
In the mol­ecule of the title compound, C15H12ClF2NO3, the quinoline ring system is not planar, the dihedral angle between the pyridine and benzene rings being 3.55 (8)°. In the crystal, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into layers parallel to (101).
doi:10.1107/S160053681104205X
PMCID: PMC3247378  PMID: 22219996
11.  6-Benzyl-6,7-dihydro-5H-pyrrolo­[3,4-b]pyridine-5,7-dione 
In the title compound, C14H10N2O2, the dihedral angle between the heterocyclic ring system and the phenyl ring is 45.8 (5)°. Weak inter­molecular C—H⋯N hydrogen bonding is present in the crystal structure.
doi:10.1107/S1600536811041006
PMCID: PMC3247312  PMID: 22219930
12.  1-Butyl-3-(1-naphtho­yl)-1H-indole 
In the title mol­ecule, C23H21NO, the dihedral angle between the planes of the indole ring and naphthalene ring system is 68.8 (5)°.
doi:10.1107/S1600536811016631
PMCID: PMC3120386  PMID: 21754743
13.  Methyl 4-(4-fluoro­phen­yl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carbox­ylate 
The asymmetric unit of the title compound, C16H17FN2O4S, contains three independent mol­ecules, in which the pyrimidine and benzene rings are oriented at dihedral angles of 41.72 (3)°, 26.21 (3)° and 36.49 (3)°. Intra­molecular C—H⋯O hydrogen bonds result in the formation of two six- and one seven-membered non-planar rings, which have have twist conformations. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules.
doi:10.1107/S1600536808013536
PMCID: PMC2961453  PMID: 21202638
14.  (Z)-5-(4-Fluoro­benzyl­idene)-1,3-thia­zolidine-2,4-dione 
In the title compound, C10H6FNO2S, the benzene and thia­zolidine rings make a dihedral angle of 7.52 (3)°. Intra­molecular C—H⋯O and C—H⋯S hydrogen bonds result in the formation of nearly planar five- and six-membered rings; the adjacent rings are nearly coplanar. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules.
doi:10.1107/S1600536807068316
PMCID: PMC2960296  PMID: 21201543

Results 1-14 (14)