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Acta Crystallographica Section E: Structure Reports Online (1)
Cardiovascular Research (1)
Plant Methods (1)
The Journal of Biological Chemistry (1)
Ding, Yanfeng (4)
Ata-Ul-Karim, Syed Tahir (1)
Davisson, Robin L. (1)
Deng, Yuheng (1)
Ding, Min (1)
Graham, Sarabeth (1)
Gryczynski, Zygmunt (1)
Kimball, Bruce A (1)
Li, Ganghua (1)
Li, Yu-Long (1)
Liu, Zhenghui (1)
Luchowski, Rafal (1)
Ma, Haiying (1)
Ma, Rong (1)
Rehmani, Muhammad Ishaq Asif (1)
Schultz, Harold D. (1)
Sours-Brothers, Sherry (1)
Wang, Shaohua (1)
Wang, Zi-jia (1)
Yan, Chuan (1)
Yao, Min (1)
Yorio, Thomas (1)
Zhang, Jingqi (1)
Zimmerman, Matthew C. (1)
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Simulation of future global warming scenarios in rice paddies with an open-field warming facility
Rehmani, Muhammad Ishaq Asif
Ata-Ul-Karim, Syed Tahir
Kimball, Bruce A
To simulate expected future global warming, hexagonal arrays of infrared heaters have previously been used to warm open-field canopies of upland crops such as wheat. Through the use of concrete-anchored posts, improved software, overhead wires, extensive grounding, and monitoring with a thermal camera, the technology was safely and reliably extended to paddy rice fields. The system maintained canopy temperature increases within 0.5°C of daytime and nighttime set-point differences of 1.3 and 2.7°C 67% of the time.
Ecosystem warming; climate change; canopy temperature; global change; infrared heating; plant-climate interactions; rice; Yangtze River valley
Acta Crystallographica Section E: Structure Reports Online
In the title compound, C19H18Br2O2, the dihedral angle between the two benzene rings of the spirobiindane molecule is 70.44 (8)°. In the crystal, molecules are interconnected along the c axis by C—H⋯O hydrogen bonds and π–π stacking [centroid–centroid distance = 3.893 (2) Å] interactions, forming an infinite chain structure. The chains are further interconnected through another set of C—H⋯O hydrogen bonds, forming layers approximately parallel to the bc plane.
Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel*
The Journal of Biological Chemistry
This study examined the effect of H2O2 on the TRPC6 channel and its underlying mechanisms using a TRPC6 heterologous expression system. In TRPC6-expressing HEK293T cells, H2O2 significantly stimulated Ca2+ entry in a dose-dependent manner. Electrophysiological experiments showed that H2O2 significantly increased TRPC6 channel open probability and whole-cell currents. H2O2 also evoked a robust inward current in A7r5 vascular smooth muscle cells, which was nearly abolished by knockdown of TRPC6 using a small interfering RNA. Catalase substantially attenuated arginine vasopressin (AVP)-induced Ca2+ entry in cells co-transfected with TRPC6 and AVP V1 receptor. N-Ethylmaleimide and thimerosal were able to simulate the H2O2 response. Dithiothreitol or glutathione-reduced ethyl ester significantly antagonized the response. Furthermore, both N-ethylmaleimide- and H2O2-induced TRPC6 activations were only observed in the cell-attached patches but not in the inside-out patches. Moreover, 1-oleoyl-2-acetyl-sn-glycerol effect on TRPC6 was significantly greater in the presence of H2O2. Biotinylation assays revealed a significant increase in cell surface TRPC6 in response to H2O2. Similarly, in cells transfected with TRPC6-EGFP, confocal microscopy showed a significant increase in fluorescence intensity in the region of the cell membrane and adjacent to the membrane. AVP also increased the fluorescence intensity on the surface of the cells co-transfected with TRPC6-EGFP and V1 receptor, and this response was inhibited by catalase. These data indicate that H2O2 activates TRPC6 channels via modification of thiol groups of intracellular proteins. This cysteine oxidation-dependent pathway not only stimulates the TRPC6 channel by itself but also sensitizes the channels to diacylglycerol and promotes TRPC6 trafficking to the cell surface.
Calcium; Calcium Channels; Calcium Transport; Reactive Oxygen Species (ROS); TRP Channels
Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits
Zimmerman, Matthew C.
Davisson, Robin L.
Schultz, Harold D.
Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this Ang II- and CHF-enhanced superoxide anion effect. Here we investigated the role of cytoplasmic SOD [CuZn superoxide dismutase (CuZnSOD)] in the CB on chemoreceptor activity and function in CHF rabbits.
Methods and results
CuZnSOD protein expression was decreased in CBs from CHF rabbits vs. sham (P < 0.05). Adenoviral CuZnSOD (Ad CuZnSOD) gene transfer to the CBs increased CuZnSOD protein expression and significantly reduced the baseline renal sympathetic nerve activity (RSNA) and the response of RSNA to hypoxia in the CHF rabbits (P < 0.05). Single-fibre discharge from CB chemoafferents during normoxia (baseline, at ∼100 mmHg PO2) and in response to hypoxia were enhanced in CHF vs. sham rabbits (P < 0.05). Ad CuZnSOD decreased the baseline discharge (7.6 ± 1.3 vs. 12.6 ± 1.7 imp/s at ∼100 mmHg PO2) and the response to hypoxia (22.4 ± 1.6 vs. 32.3 ± 1.2 imp/s at ∼40 mmHg PO2, P < 0.05) in CHF rabbits. Ad CuZnSOD also normalized the blunted outward K+ current (IK) in CB glomus cells from CHF rabbits (369 ± 14 vs. 565 ± 31 pA/pF at +70 mV, P < 0.05). In addition, Ad CuZnSOD reduced the elevation of superoxide level in CBs from CHF rabbits.
Downregulation of CuZnSOD in the CB contributes to the enhanced activity of CB chemoreceptors and chemoreflex function in CHF rabbits.
Superoxide dismutase; Adenoviral vector; Carotid body; Sympathetic nerve activity; Chemoreceptor; Glomus cell; Chronic heart failure
Results 1-4 (4)
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