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1.  Chromosome Replication in Salmonella typhimurium1 
Journal of Bacteriology  1969;97(2):848-860.
The replication of the Salmonella typhimurium chromosome was studied. As with E. coli 15T−, replication was sequential. After amino acid starvation, replication proceeded from a unique and heritable region of the chromosome. 5-Bromouracil, when substituted for thymine, did not disturb the sequence of replication nor did it initiate extra replication cycles. By labeling the origin and the terminus of the chromosome with 3H- and 14C-thymine, respectively, it was possible to determine that the rate of chain elongation decreases as the growth rate decreases. No gap in the replication cycle could be observed.
PMCID: PMC249769  PMID: 4886297

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