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2.  Three-Dimensional Dosimetry of a Beta-Emitting Radionuclide Using PRESAGE® Dosimeters 
Three-dimensional dose distributions from liquid brachytherapy were measured using PRESAGE® dosimeters. The dosimeters were exposed to Y-90 for 5.75 days and read by optical tomography. The distributions are consistent with estimates from beta dose kernels.
PMCID: PMC3016851  PMID: 21218189
3.  Comparison of the effects on pupil size and accommodation of three regimens of topical dapiprazole. 
BACKGROUND--Patients who have their pupils dilated for an eye examination traditionally have to wait several hours before their pupils return to normal size and their blurred vision (caused by paralysis of accommodation) resolves. Earlier studies with dapiprazole have demonstrated an accelerated reversal of dilatation. METHODS--Three regimens of dapiprazole were studied to determine the effects on pupil diameter and accommodation after mydriasis produced by 2.5% phenylephrine and 0.5% tropicamide. Test regimens included one drop and 1 + 1 drop regimens, compared with a 2 + 2 drop reference regimen. Dapiprazole was administered in one eye and placebo in the other. Mean change from baseline was analysed for pupil diameter and accommodation at various time points after drug administration. Also, for the same variables, 90% confidence intervals for the areas under the curve (AUC) were computed. RESULTS--Both test regimens were equivalent to the reference regimen on the basis of mean change from baseline for pupil diameter and accommodation at individual time points, and for the mean AUC. Most signs and symptoms (injection, stinging, burning, lid oedema, and ptosis) were less frequent in the test regimen treated eyes. There was no significant interaction between regimen and eye colour. CONCLUSION--This study indicates that a lower dosage (for example, one drop) is also efficacious and has the added benefit of fewer side effects.
PMCID: PMC505162  PMID: 7626570
4.  Bowel function measurements of individuals with different eating patterns. 
Gut  1986;27(2):164-169.
Bowel function was assessed in 51 subjects: 10 women and seven men who habitually consumed an omnivorous, vegetarian, or vegan diet. The subjects on these diets had a mean intake of fibre of 23 g, 37 g, and 47 g respectively. Mean transit times were variable and not significantly different between the groups. Vegans, however, had a greater frequency of defecation and passed softer stools. All measurements of bowel function were significantly correlated with total dietary fibre. As dietary fibre increased mean transit time decreased, stool frequency increased and the stools became softer. Men produced a greater quantity of softer, less formed faeces than women. During the luteal phase of the menstrual cycle women excreted harder stools and had a significantly longer mean transit time. The finding that mean transit time was more highly correlated with faecal form than any of the other bowel function measurements could be of practical importance.
PMCID: PMC1433202  PMID: 3005140
5.  Isodicentric X chromosome in a moderately tall patient with gonadal dysgenesis: lack of effect of functional centromere on inactivation pattern. 
Journal of Medical Genetics  1982;19(6):463-465.
An isodicentric X chromosome (46, X idic (X)(pter leads to qter::qter leads to pter)) with a single functioning centromere was found in all lymphocytes and fibroblasts examined from a female patient 171.5 cm in height presenting with primary amenorrhoea. Replication of the abnormal chromosome was consistently late. In some cells the pattern was asymmetrical but the asymmetry did not appear to relate to the position of the active centromere.
PMCID: PMC1048964  PMID: 7154045
6.  Effect of vaccination on severity and dissemination of whooping cough. 
A study was undertaken in general practice to clarify those factors, especially vaccinations, that influence the clinical picture and infectivity of whooping cough in the community. Although the range of the disease encountered was fairly mild, its duration was notable (mean +/- SD 50.9 +/- 32.1 days). By using multiway contingency table analysis it was found that in the more severe cases of whooping cough vaccination significantly shortened the illness (p less than 0.005) and reduced the number of coughing spasms (p less than 0.025). The protective effect of the vaccine was most notable in modifying infectivity within the family: 19% of vaccinated family contacts of index patients in whom the disease had been confirmed bacteriologically developed the disease when exposed to it compared with 72% of non-vaccinated contacts (p less than 0.001). These results show that whooping cough vaccination modifies the clinical illness and offers a worthwhile degree of protection to children exposed to the disease.
PMCID: PMC1505783  PMID: 6263402
7.  The effect of weather on some infectious diseases 
For several years the Royal College of General Practitioners has been collecting data supplied by local doctors throughout Britain on some infectious diseases seen in their practices. We describe a method of computerisation of this information and statistical analyses. We are investigating the influence of external factors such as climate on the infectiousness of some diseases. A model is fitted involving a non homogeneous two-state Markov chain whose transition probabilities are governed by the explanatory data.
PMCID: PMC2157692  PMID: 1177220
8.  A trace gas technique for measuring clothing microclimate air exchange rates 
Crockford, G. W., Crowder, M., and Prestidge, S. P. (1972).Brit. J. industr. Med.,29, 378-386. A trace gas technique for measuring clothing microclimate air exchange rates. The rate at which clothing microclimate air is exchanged for ambient air influences the sensible and insensible heat loss from the microclimate. Factors which influence this air exchange are clothing permeability, wind speed, body movements, clothing design, and fabric properties. The influence of the first four factors has been studied using a trace gas technique for measuring the rate at which microclimate air is exchanged for ambient air. The trace gas technique and the mathematical model describing the loss of the trace gas from the microclimate are described. The technique is shown to have a high resolving power, enabling small changes in the four factors studied to be identified, and as the method is also very quick detailed studies of garment design can be made.
PMCID: PMC1009453  PMID: 4636659

Results 1-8 (8)