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International Journal of Clinical and Experimental Pathology (1)
Journal of Hematopathology (1)
The Canadian Journal of Infectious Diseases & Medical Microbiology (1)
Ahsanuddin, Arshad N (2)
Ahsanuddin, Arshad N. (1)
Brynes, Russell K (1)
Brynes, Russell K. (1)
Bullard, Jared MP (1)
Dibernardo, Antonia (1)
Grody, Wayne W. (1)
Iranpour, Mahmood (1)
Kroft, Steven H. (1)
Li, Shiyong (1)
Lindsay, L Robbin (1)
Mann, Karen P. (1)
Perry, Anamarija M (1)
Pullarkat, Sheeja T. (1)
Pullarkat, Vinod (1)
Thein, Maung (1)
Van Caeseele, Paul G (1)
Wilson, Carla S. (1)
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The first case of locally acquired tick-borne Babesia microti infection in Canada
Bullard, Jared MP
Perry, Anamarija M
Lindsay, L Robbin
Van Caeseele, Paul G
The Canadian Journal of Infectious Diseases & Medical Microbiology
Infection with Babesia microti can cause severe illness, particularly among asplenic individuals. Blacklegged and Western blacklegged ticks (Ixodes scapularis and Ixodes pacificus, respectively) are the vector through which B microti is transmitted. The distribution of these ticks in Canada has increased over the past several years. In this article, the authors present the first case of babesiosis in Canada that was not diagnosed following travel to an area in which the disease is endemic.
A child with a complicated medical history that included asplenia acquired an infection with Babesia microti in the summer of 2013 and had not travelled outside of Manitoba. Although the clinical findings were subtle, astute laboratory work helped to reach a preliminary identification of Babesia species, while reference laboratory testing confirmed the diagnosis. Blacklegged ticks (Ixodes scapularis) are known to transmit Borrelia burgdorferi and Anaplasma phagocytophilum in the province; however, the present case represents the first known instance of tick-borne B microti, both in Manitoba and in Canada. The expanding territory of the blacklegged tick increases the relevance of this emerging infection. Clinicians, laboratory medical practitioners and public health officials should be aware of B microti as a potential locally acquired infection in Canada.
Babesia microti; Babesiosis; Blacklegged ticks; Canada; Emerging infection; Local acquisition
Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: report of 3 cases and review of the literature
Brynes, Russell K
International Journal of Clinical and Experimental Pathology
Angioimmunoblastic T-cell lymphoma (AITL) is a unique type of peripheral T-cell lymphoma. Patients with AITL may have occasional reactive plasma cells present in the peripheral circulation. Prominent peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia, however, is distinctly uncommon. Here we describe 3 such cases from two large tertiary medical centers and discuss the role of ancillary studies in the differential diagnosis of peripheral blood plasmacytosis.
Angioimmunoblastic T-cell lymphoma; peripheral blood; plasmacytosis; flow cytometric immunopheno-typing
Systemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemia
Pullarkat, Sheeja T.
Kroft, Steven H.
Wilson, Carla S.
Mann, Karen P.
Grody, Wayne W.
Brynes, Russell K.
Journal of Hematopathology
Although KIT mutations are present in 20–25% of cases of t(8;21)(q22;q22) acute myeloid leukemia (AML), concurrent development of systemic mastocytosis (SM) is exceedingly rare. We examined the clinicopathologic features of SM associated with t(8;21)(q22;q22) AML in ten patients (six from our institutions and four from published literature) with t(8;21) AML and SM. In the majority of these cases, a definitive diagnosis of SM was made after chemotherapy, when the mast cell infiltrates were prominent. Deletion 9q was an additional cytogenetic abnormality in four cases. Four of the ten patients failed to achieve remission after standard chemotherapy and seven of the ten patients have died of AML. In the two patients who achieved durable remission after allogeneic hematopoietic stem cell transplant, recipient-derived neoplastic bone marrow mast cells persisted despite leukemic remission. SM associated with t(8;21) AML carries a dismal prognosis; therefore, detection of concurrent SM at diagnosis of t(8;21) AML has important prognostic implications.
Systemic mastocytosis; Acute myeloid leukemia; KIT mutations; Pathogenesis; Translocation (8;21); Prognosis
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