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Diabetes Care (1)
Indian Journal of Clinical Biochemistry (1)
Ismail, Ikram Shah (2)
Ali, Osman (1)
Chinna, Karuthan (1)
Isa, Siti Harnida Md (1)
Ismail, Ab Aziz (1)
Kadir, Khalid Abdul (1)
Kamarudin, Nor Azmi (1)
Khir, Amir Sharifuddin (1)
Muniandy, Sekaran (1)
Musa, Kamarul Imran (1)
Mustafa, Norlaila (1)
Qvist, Rajes (1)
Wan Bebakar, Wan Mohamad (1)
Yaacob, Nor Azwany (1)
wan Mohamud, Wan Nazaimoon (1)
Year of Publication
Prevalence of Abnormal Glucose Tolerance and Risk Factors in Urban and Rural Malaysia
Kamarudin, Nor Azmi
Ismail, Ab Aziz
Khir, Amir Sharifuddin
Musa, Kamarul Imran
Kadir, Khalid Abdul
Yaacob, Nor Azwany
Isa, Siti Harnida Md
Wan Bebakar, Wan Mohamad
wan Mohamud, Wan Nazaimoon
To determine the prevalence of prediabetes and diabetes among rural and urban Malaysians.
RESEARCH DESIGN AND METHODS
This cross-sectional survey was conducted among 3,879 Malaysian adults (1,335 men and 2,544 women). All subjects underwent the 75-g oral glucose tolerance test (OGTT).
The overall prevalence of prediabetes was 22.1% (30.2% in men and 69.8% in women). Isolated impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) were found in 3.4 and 16.1% of the study population, respectively, whereas 2.6% of the subjects had both IFG and IGT. Based on an OGTT, the prevalence of newly diagnosed type 2 diabetes was 12.6% (31.0% in men and 69.0% in women). The prediabetic subjects also had an increased prevalence of cardiovascular disease risk factors.
The large proportion of undiagnosed cases of prediabetes and diabetes reflects the lack of public awareness of the disease.
Use of glycated hemoglobin (HbA1C) and impaired glucose tolerance in the screening of undiagnosed diabetes in the Malaysian population
Indian Journal of Clinical Biochemistry
Although HbA1C is widely accepted as a useful index of mean blood glucose in type 2 diabetic patients its usefulness as screening test for diabetes has been controversial. The present study was undertaken to determine whether the level of HbA1C predicted diabetes in a prediabetic group of subjects. Plasma lipids, oral glucose tolerance, HbA1C was determined in 90 normal control subjects, 57 offspring of one type 2 diabetes mellitus parent and 11 diagnosed type 2 diabetes mellitus individuals. The mean age of participants was 44.5 yrs (not significantly different amongst the three groups) and the mean body mass index was 26.8 (not significantly different amongst the three groups). Two hours after a 75 g glucose challenge, the offspring had a significantly higher plasma glucose level (mean = 7.1 mmol/L, p value = 0.002) than the normals. Similarly the HbA1C values were higher in the offspring than in the normals (mean = 5.78%, p value = 0.016). Besides the significantly higher values for oral glucose tolerance test and HbA1C, the diabetics also were significantly higher for triglycerides (mean = 2.25mmol/L), total cholesterol (mean = 6.24mmol/L) and systolic blood pressure (mean = 138.45mm Hg) than the offspring (P value = 0.031, 0.006, 0.010) and the normals (P value = 0.026, 0.018, 0.002) respectively. The mean values of diastolic blood pressure, LDL cholesterol and HDL cholesterol were not significantly different amongst the three groups.
Diabetes mellitus; HbA1C; Prediabetic; Fasting blood glucose; Insulin resistance
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