Enter Your Search:
Results 1-5 (5)
Go to page number:
Select a Filter Below
Acta Crystallographica Section F: Structural Biology and Crystallization Communications (1)
BMJ : British Medical Journal (1)
Interactive Cardiovascular and Thoracic Surgery (1)
Journal of the National Medical Association (1)
Burton, Andrew (2)
Aherne, Julian (1)
Alphey, Magnus S. (1)
Barlow, Clifford W. (1)
Boons, Geert-Jan (1)
Burton, Andrew F. (1)
Burton, Andrew James (1)
Burton, Andrew W. (1)
Drew, Charles R. (1)
Ferguson, Michael A. J. (1)
Hunter, William N. (1)
Livesey, Steve A. (1)
Ohri, Sunil K. (1)
Roubelakis, Apostolos (1)
Tsang, Geoffrey M.K. (1)
Urbaniak, Michael D. (1)
Vohra, Hunaid A. (1)
Whistance, Robert N. (1)
Year of Publication
Outcome after redo-mitral valve replacement in adult patients: a 10-year single-centre experience
Vohra, Hunaid A.
Whistance, Robert N.
Barlow, Clifford W.
Tsang, Geoffrey M.K.
Livesey, Steve A.
Ohri, Sunil K.
Interactive Cardiovascular and Thoracic Surgery
The aim of this study was to investigate the overall outcome of adult patients undergoing redo-mitral valve replacement (redo-MVR) at our institution. Forty-nine patients (24 males) underwent redo-MVR with either bioprosthetic (n = 24) or mechanical valves (n = 25) between January 2000 and 2010. Median age of patients was 63 years (range 21–80 years), and the mean additive EuroSCORE was 12 ± 4. Median time to re-operation was 8.2 ± 6.6 years for first time redo-MVR and 6.4 ± 5.6 years for second-time redo-MVR. Indications included prosthetic endocarditis (n = 22), para-prosthetic leak (n = 12), structural valve degeneration (n = 8), prosthetic valve thrombosis (n = 6) and malignancy (n = 1). The mean follow-up was 47.5 ± 37.0 months (range 0.1–112.3 months). In-hospital mortality was 12% (n = 6). Mean hospital stay was 17 ± 11 days (range 8–50 days). Actuarial survival at 1 and 5 years was 81 ± 5% and 72 ± 6%, respectively. Three patients required re-intervention: two for prosthetic valve endocarditis and one for para-prosthetic leak. Multivariate analysis showed that overall survival was associated with the LVEF < 50% (P < 0.001), concomitant AVR (P < 0.001) and urgent surgery (P = 0.03).
Mitral; Redo; Outcome
Changes in the Chemistry of Small Irish lakes
A re-survey of acid-sensitive lakes in Ireland (initial survey 1997) was carried out during spring 2007 (n = 60). Since 1997, atmospheric emissions of sulfur dioxide and deposition of non-marine sulfate (SO42−) in Ireland have decreased by ~63 and 36%, respectively. Comparison of water chemistry between surveys showed significant decreases in the concentration of SO42−, non-marine SO42−, and non-marine base cations. In concert, alkalinity increased significantly; however, no change was observed in surface water pH and total aluminum. High inter-annual variability in sea salt inputs and increasing (albeit non-significant) dissolved organic carbon may have influenced the response of pH and total aluminum (as ~70% is organic aluminum). Despite their location on the western periphery of Europe, and dominant influence from Atlantic air masses, the repeat survey suggests that the chemistry of small Irish lakes has shown a significant response to reductions in air pollution driven primarily by the implementation of the Gothenburg Protocol under the UNECE Convention on Long-Range Transboundary Air Pollution.
Lake chemistry; Sulfate; Emissions; Sea salts; Dissolved organic carbon
Congenital coronary artery disease
BMJ : British Medical Journal
Trypanosoma brucei UDP-galactose-4′-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-α-d-galactose
Alphey, Magnus S.
Urbaniak, Michael D.
Ferguson, Michael A. J.
Hunter, William N.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
The structure of recombinant T. brucei UDP-galactose-4′-epimerase cocrystallized with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-α-d-galactose has been determined at medium resolution. Comparisons with structures of human and E. coli UDP-galactose-4′-epimerase–ligand complexes reveal that the hexose moieties are able to adopt different orientations in the active site.
The structure of the NAD-dependent oxidoreductase UDP-galactose-4′-epimerase from Trypanosoma brucei in complex with cofactor and the substrate analogue UDP-4-deoxy-4-fluoro-α-d-galactose has been determined using diffraction data to 2.7 Å resolution. Despite the high level of sequence and structure conservation between the trypanosomatid enzyme and those from humans, yeast and bacteria, the binding of the 4-fluoro-α-d-galactose moiety is distinct from previously reported structures. Of particular note is the observation that when bound to the T. brucei enzyme, the galactose moiety of this fluoro-derivative is rotated approximately 180° with respect to the orientation of the hexose component of UDP-glucose when in complex with the human enzyme. The architecture of the catalytic centre is designed to effectively bind different orientations of the hexose, a finding that is consistent with a mechanism that requires the sugar to maintain a degree of flexibility within the active site.
short-chain dehydrogenase/reductases; Trypanosoma brucei; UDP-galactose-4′-epimerase; UDP-4-deoxy-4-fluoro-α-d-galactose
Drew, Charles R.
Journal of the National Medical Association
Results 1-5 (5)
Go to page number:
Remove citation from clipboard
Add citation to clipboard
This will clear all selections from your clipboard. Do you wish proceed?
Clipboard is full! Please remove an item and try again.
PubMed Central Canada is a service of the
Canadian Institutes of Health Research
(CIHR) working in partnership with the National Research Council's
Canada Institute for Scientific and Technical Information
in cooperation with the
National Center for Biotechnology Information
U.S. National Library of Medicine
(NCBI/NLM). It includes content provided to the
PubMed Central International archive
by participating publishers.