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author:("bottom, D G")
1.  Nephrogenic Diabetes Insipidus 
Archives of Disease in Childhood  1972;47(255):794-797.
In view of the evidence that the actions of vasopressin are mediated by the release of adenosine 3,5, cyclic monophosphate (`cyclic-AMP'), the effects of this nucleotide were studied in 3 children with nephrogenic diabetes insipidus (NDI) who were insensitive to vasopressin.
Intravenous injections of cyclic-AMP reduced urine flow in 2 of the 3 patients, but did not increase urinary osmolality nor the urinary concentrations of sodium, creatinine, and urea. In these respects the antidiuresis differed from that normally produced by vasopressin.
The reduction in urine flow produced by cyclic-AMP was probably related to a fall in glomerular filtration rate associated with the prominent circulatory effects of the nucleotide. These effects appear to preclude the use of cyclic-AMP as an antidiuretic agent in the treatment of NDI.
PMCID: PMC1648252  PMID: 4343784
2.  Effect of Asphyxia on Thrombotest Values in Low Birthweight Infants 
Archives of Disease in Childhood  1970;45(243):705-707.
Thrombotest was used as a measure of coagulation status in 55 low birthweight infants. The initial levels were similar in both babies who were asphyxiated at birth and in those who had uncomplicated deliveries. On the other hand, 24 hours after giving vitamin K1, a rise in the mean percentage thrombotest activity was confined to the normal delivery group. No significant rise occurred in the babies who suffered from hypoxia. It is suggested that fresh frozen plasma should be given particularly to asphyxiated low birthweight infants in an effort to diminish their liability to haemorrhage.
PMCID: PMC1647529  PMID: 5477687
4.  Leukaemic Meningitis 
Archives of Disease in Childhood  1961;36(188):424-425.
PMCID: PMC2012712  PMID: 13695897
5.  Acute Cerebellar Ataxia 
Archives of Disease in Childhood  1957;32(163):181-188.
PMCID: PMC2012079  PMID: 13445296
6.  Congenital Lobar Emphysema 
British Medical Journal  1957;1(5032):1394-1390.4.
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PMCID: PMC1973649  PMID: 13436798

Results 1-9 (9)