Maternal asthma is associated with serious pregnancy complications but newborn morbidity is understudied.
To determine if infants of asthmatic mothers have more neonatal complications.
The Consortium on Safe Labor (2002–2008), a retrospective cohort, included 223,512 singleton deliveries at ≥ 23 weeks’ gestation. Newborns of mothers with asthma (n=17,044) were compared to newborns of non-asthmatic women using logistic regression models with generalized estimating equations to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI). Electronic medical record data included gestational week at delivery, birthweight, resuscitation, neonatal intensive care unit (NICU) admission, NICU length of stay, hyperbilirubinemia, respiratory distress syndrome, apnea, sepsis, anemia, transient tachypnea of the newborn, infective pneumonia, asphyxia, intracerebral hemorrhage, seizure, cardiomyopathy, peri- or intraventricular hemorrhage, necrotizing enterocolitis, aspiration, retinopathy of prematurity and perinatal mortality.
Preterm delivery was associated with maternal asthma for each week after 33 completed weeks of gestation and not earlier. Maternal asthma also increased the adjusted odds of small for gestational age (SGA, OR=1.10, CI:1.05–1.16), NICU admission (OR=1.12, CI:1.07–1.17), hyperbilirubinemia (OR=1.09, CI:1.04–1.14), respiratory distress syndrome (OR=1.09, CI:1.01–1.19), transient tachypnea of the newborn (OR=1.10, CI:1.02–1.19), and asphyxia (OR=1.34, CI:1.03–1.75). Findings persisted for term infants (≥ 37 weeks) who had additional increased odds of intracerebral hemorrhage (OR=1.84, CI: 1.11–3.03) and anemia (OR=1.30, CI: 1.04–1.62).
Maternal asthma was associated with prematurity and SGA. Adverse neonatal outcomes including respiratory complications, hyperbilirubinemia, and NICU admission were increased in association with maternal asthma even among term deliveries.