Enter Your Search:
Results 1-2 (2)
Go to page number:
Select a Filter Below
International Journal of Molecular Sciences (1)
Journal of Nutrigenetics and Nutrigenomics (1)
Lockett, Trevor (2)
Buckley, Michael (1)
Cahill, Leah (1)
Cosgrove, Leah (1)
Cosgrove, Leah J. (1)
El-Sohemy, Ahmed (1)
Fenech, Michael (1)
Ferguson, Lynnette R. (1)
French, Tapaeru-Ariki C. (1)
Fung, Kim Y. C. (1)
Fung, Kim Y.C. (1)
Head, Richard (1)
Koh, Woon-Puay (1)
Milner, John (1)
Ooi, Cheng Cheng (1)
Tai, E. Shyong (1)
Topping, David L. (1)
Williams, Desmond B. (1)
Xie, Lin (1)
Zucker, Michelle (1)
Zucker, Michelle H. (1)
Year of Publication
Colorectal Carcinogenesis: A Cellular Response to Sustained Risk Environment
Ooi, Cheng Cheng
Zucker, Michelle H.
Williams, Desmond B.
Cosgrove, Leah J.
Topping, David L.
International Journal of Molecular Sciences
The current models for colorectal cancer (CRC) are essentially linear in nature with a sequential progression from adenoma through to carcinoma. However, these views of CRC development do not explain the full body of published knowledge and tend to discount environmental influences. This paper proposes that CRC is a cellular response to prolonged exposure to cytotoxic agents (e.g., free ammonia) as key events within a sustained high-risk colonic luminal environment. This environment is low in substrate for the colonocytes (short chain fatty acids, SCFA) and consequently of higher pH with higher levels of free ammonia and decreased mucosal oxygen supply as a result of lower visceral blood flow. All of these lead to greater and prolonged exposure of the colonic epithelium to a cytotoxic agent with diminished aerobic energy availability. Normal colonocytes faced with this unfavourable environment can transform into CRC cells for survival through epigenetic reprogramming to express genes which increase mobility to allow migration and proliferation. Recent data with high protein diets confirm that genetic damage can be increased, consistent with greater CRC risk. However, this damage can be reversed by increasing SCFA supply by feeding fermentable fibre as resistant starch or arabinoxylan. High protein, low carbohydrate diets have been shown to alter the colonic environment with lower butyrate levels and apparently greater mucosal exposure to ammonia, consistent with our hypothesis. Evidence is drawn from in vivo and in vitro genomic and biochemical studies to frame experiments to test this proposition.
ammonia; colorectal cancer; dietary protein; resistant starch; short chain fatty acid
Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice
Ferguson, Lynnette R.
French, Tapaeru-Ariki C.
Tai, E. Shyong
Journal of Nutrigenetics and Nutrigenomics
Nutrigenetics and nutrigenomics hold much promise for providing better nutritional advice to the public generally, genetic subgroups and individuals. Because nutrigenetics and nutrigenomics require a deep understanding of nutrition, genetics and biochemistry and ever new ‘omic’ technologies, it is often difficult, even for educated professionals, to appreciate their relevance to the practice of preventive approaches for optimising health, delaying onset of disease and diminishing its severity. This review discusses (i) the basic concepts, technical terms and technology involved in nutrigenetics and nutrigenomics; (ii) how this emerging knowledge can be applied to optimise health, prevent and treat diseases; (iii) how to read, understand and interpret nutrigenetic and nutrigenomic research results, and (iv) how this knowledge may potentially transform nutrition and dietetic practice, and the implications of such a transformation. This is in effect an up-to-date overview of the various aspects of nutrigenetics and nutrigenomics relevant to health practitioners who are seeking a better understanding of this new frontier in nutrition research and its potential application to dietetic practice.
Dietetics; Nutrigenetics; Nutrigenomics; Nutrition Research; Personalised nutrition
Results 1-2 (2)
Go to page number:
Remove citation from clipboard
Add citation to clipboard
This will clear all selections from your clipboard. Do you wish proceed?
Clipboard is full! Please remove an item and try again.
PubMed Central Canada is a service of the
Canadian Institutes of Health Research
(CIHR) working in partnership with the National Research Council's
Canada Institute for Scientific and Technical Information
in cooperation with the
National Center for Biotechnology Information
U.S. National Library of Medicine
(NCBI/NLM). It includes content provided to the
PubMed Central International archive
by participating publishers.