Enter Your Search:
Results 1-2 (2)
Go to page number:
Select a Filter Below
Developmental cognitive neuroscience (1)
Epilepsy & behavior : E&B (1)
Katzir, Tami (2)
Barzillai, Mirit (1)
Bookheimer, Susan (1)
Bramen, Jennifer (1)
Chang, Bernard S. (1)
Chu, Felicia (1)
Corriveau, Kathleen (1)
Dapretto, Mirella (1)
Hackney, David B. (1)
Kan, Eric (1)
Liu, Tianming (1)
Ly, Jenny (1)
Nuñez, S. Christopher (1)
O'Connor, Margaret G. (1)
Sowell, Elizabeth R. (1)
Starr, Ariel (1)
Walker, Linsey M. (1)
Year of Publication
fMRI of syntactic processing in typically developing children: structural correlates in the inferior frontal gyrus
Nuñez, S. Christopher
Sowell, Elizabeth R.
Developmental cognitive neuroscience
Development of syntactic processing was examined to evaluate maturational processes including left language lateralization functions and increased specialization of brain regions important for syntactic processing. We utilized multimodal methods, including indices of brain activity from fMRI during a syntactic processing task, cortical thickness measurements from structural MRI, and neuropsychological measures. To evaluate hypotheses about increasing lateralization and specialization with development, we examined relationships between cortical thickness and magnitude and spatial activation extent within the left inferior frontal gyrus (IFG) and its right hemisphere homologue. We predicted that increased activation in the left and decreased activation in the right IFG would be associated with increased syntactic proficiency. As predicted, a more mature pattern of increased thickness in the right pars triangularis was associated with decreased activation intensity and extent in the right IFG. These findings suggest a maturational shift towards decreased involvement of the right IFG for syntactic processing. Better syntactic skills were associated with increased activation in the left IFG independent from age, suggesting increased specialization of the left IFG with increased proficiency. Overall, our findings show relationships between structural and functional neurodevelopment that co-occur with improved syntactic processing in critical language regions of the IFG in typically developing children.
Syntax; language; typical development; lateralization; fMRI; multimodal
Gray matter volumes and cognitive ability in the epileptogenic brain malformation of periventricular nodular heterotopia
Walker, Linsey M.
O'Connor, Margaret G.
Hackney, David B.
Chang, Bernard S.
Epilepsy & behavior : E&B
Periventricular nodular heterotopia (PNH) is a brain malformation clinically characterized by the triad of epilepsy, normal intelligence, and dyslexia. We investigated the structure-function relationship between cerebral volumes and cognitive ability in this disorder by studying twelve PNH subjects and six controls using volumetric analysis of high-resolution anatomical MRI and neuropsychological testing. Total cerebral volumes and specific brain compartment volumes (gray matter, white matter, and CSF) in PNH subjects were comparable to those in controls. There was a negative correlation between heterotopic gray matter volume and cortical gray matter volume. Cerebral and cortical volumes in PNH did not correlate with full-scale IQ, unlike in normal individuals. Our findings support the idea that heterotopic nodules contain misplaced neurons that would normally have migrated to the cortex, and suggest that structural correlates of normal cognitive ability may be different in the setting of neuronal migration failure.
Periventricular nodular heterotopia; malformation of cortical development; volumetric MRI; intelligence
Results 1-2 (2)
Go to page number:
Remove citation from clipboard
Add citation to clipboard
This will clear all selections from your clipboard. Do you wish proceed?
Clipboard is full! Please remove an item and try again.
PubMed Central Canada is a service of the
Canadian Institutes of Health Research
(CIHR) working in partnership with the National Research Council's
Canada Institute for Scientific and Technical Information
in cooperation with the
National Center for Biotechnology Information
U.S. National Library of Medicine
(NCBI/NLM). It includes content provided to the
PubMed Central International archive
by participating publishers.