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Biologics : Targets & Therapy (1)
European journal of pharmacology (1)
Tejani, Mohamedtaki A. (2)
Chandwani, Kavita (1)
Cohen, Roger B (1)
Galloway, Thomas J. (1)
Janelsins, Michelle (1)
Kamen, Charles (1)
Lango, Miriam (1)
Mehra, Ranee (1)
Morrow, Gary R. (1)
Peoples, Anita R. (1)
Ridge, John A. (1)
Roscoe, Joseph A. (1)
Tejani, Mohamedtaki A (1)
von Mehren, Margaret (1)
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Anticipatory nausea and vomiting due to chemotherapy
Peoples, Anita R.
Roscoe, Joseph A.
Morrow, Gary R.
European journal of pharmacology
As a specific variation of chemotherapy-induced nausea and vomiting, anticipatory nausea and vomiting (ANV) appears particularly linked to psychological processes. The three predominant factors related to ANV are classical conditioning; demographic and treatment-related factors; and anxiety or negative expectancies. Laboratory models have provided some support for these underlying mechanisms for ANV. ANV may be treated with medical or pharmacological interventions, including benzodiazepines and other psychotropic medications. However, behavioral treatments, including systematic desensitization, remain first line options for addressing ANV. Some complementary treatment approaches have shown promise in reducing ANV symptoms. Additional research into these approaches is needed. This review will address the underlying models of ANV and provide a discussion of these various treatment options.
Head and Neck Sarcomas: A Comprehensive Cancer Center Experience
Galloway, Thomas J.
Ridge, John A.
von Mehren, Margaret
Head/neck sarcomas are rare, accounting for about 1% of head/neck malignancies and 5% of sarcomas. Outcomes have historically been worse in this group, due to anatomic constraints leading to difficulty in completely excising tumors, with high rates of local recurrence. We retrospectively analyzed cases of head/neck soft tissue sarcomas (STS) and osteogenic sarcomas managed in a multi-disciplinary setting at Fox Chase Cancer Center from 1999–2009 to describe clinicopathologic characteristics, treatment, outcomes, and prognostic factors for disease control and survival. Thirty patients with STS and seven patients with osteogenic sarcoma were identified. Most STS were high grade (23) and almost all were localized at presentation (28). Common histologies were synovial cell (6), rhabdomyosarcoma (5), angiosarcoma (4), liposarcoma (4) and leiomyosarcoma (3). The type of primary therapy and disease outcomes were analyzed. Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS). The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.
head and neck sarcomas; soft tissue sarcomas; osteogenic sarcomas
The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer
Cohen, Roger B
Biologics : Targets & Therapy
Recurrent and/or metastatic squamous cell carcinoma of the head and neck (HNSCC) continues to be a source of significant morbidity and mortality worldwide. Agents that target the epidermal growth factor receptor (EGFR) have demonstrated beneficial effects in this setting. Cetuximab, a monoclonal antibody against the EGFR, improves locoregional control and overall survival when used as a radiation sensitizer in patients with locoregionally advanced HNSCC undergoing definitive radiation therapy with curative intent. Cetuximab is also active as monotherapy in patients whose cancer has progressed on platinum-containing therapy. In the first-line setting for incurable HNSCC, cetuximab added to platinum-based chemotherapy significantly improves overall survival compared with standard chemotherapy alone. These positive results have had a significant impact on the standard of care for advanced HNSCC. In this review, we will discuss the mechanism of action, clinical data and common toxicities that pertain to the use of cetuximab in the treatment of advanced incurable HNSCC.
cetuximab; squamous cell carcinoma of the head and neck; epidermal growth factor receptor
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