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1.  ABCA1 POLYMORPHISMS AND ALZHEIMER’S DISEASE 
Neuroscience letters  2007;416(2):180-183.
In our search for genetic factors related to the development of Alzheimer’s disease, we have genotyped 332 pedigrees for 3 coding polymorphisms in the ABCA1 gene, two of which are known to alter plasma cholesterol levels, as well as a non-coding polymorphism within the promoter. We show an apparent weak association of rs2230806 (p-value= 0.01) with the disease in a sibpair series of Alzheimer’s disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps.
doi:10.1016/j.neulet.2007.02.010
PMCID: PMC1945126  PMID: 17324514
ABCA1; Alzheimer’s disease; polymorphisms
2.  Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs 
BMC Medical Genetics  2009;10:122.
Background
Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes.
Methods
In the present study, we have combined a selection of affected relative pairs (ARPs) from the UK and the USA included in a previous linkage study by Myers et al. (Am J Med Genet, 2002), with ARPs from Sweden and Washington University. In this total sample collection of 397 ARPs, we have analyzed linkage to chromosomes 1, 9, 10, 12, 19 and 21, implicated in the previous scan.
Results
The analysis revealed that linkage to chromosome 19q13 close to the APOE locus increased considerably as compared to the earlier scan. However, linkage to chromosome 10q21, which provided the strongest linkage in the previous scan could not be detected.
Conclusion
The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.
doi:10.1186/1471-2350-10-122
PMCID: PMC2791756  PMID: 19951422

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