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Frontiers in Integrative Neuroscience (1)
Journal of Clinical Investigation (1)
Audoly, Laurent P. (1)
Coffman, Thomas M. (1)
Flannery, Patrick J. (1)
McNeish, John D. (1)
Stock, Jeffrey L. (1)
Burkhardt, John (1)
Burkhardt, John M. (1)
Costa, Rui M. (1)
Ishikawa, Toshihisa (1)
Jin, Xin (1)
Kim, Hyung-Suk (1)
Roach, Marsha (1)
Shinjo, Katsuhiro (1)
Taniguchi, Kana (1)
Year of Publication
Dissociable Effects of Dopamine on Neuronal Firing Rate and Synchrony in the Dorsal Striatum
Costa, Rui M.
Frontiers in Integrative Neuroscience
Previous studies showed that dopamine depletion leads to both changes in firing rate and in neuronal synchrony in the basal ganglia. Since dopamine D1 and D2 receptors are preferentially expressed in striatonigral and striatopallidal medium spiny neurons, respectively, we investigated the relative contribution of lack of D1 and/or D2-type receptor activation to the changes in striatal firing rate and synchrony observed after dopamine depletion. Similar to what was observed after dopamine depletion, co-administration of D1 and D2 antagonists to mice chronically implanted with multielectrode arrays in the striatum caused significant changes in firing rate, power of the local field potential (LFP) oscillations, and synchrony measured by the entrainment of neurons to striatal local field potentials. However, although blockade of either D1 or D2 type receptors produced similarly severe akinesia, the effects on neural activity differed. Blockade of D2 receptors affected the firing rate of medium spiny neurons and the power of the LFP oscillations substantially, but it did not affect synchrony to the same extent. In contrast, D1 blockade affected synchrony dramatically, but had less substantial effects on firing rate and LFP power. Furthermore, there was no consistent relation between neurons changing firing rate and changing LFP entrainment after dopamine blockade. Our results suggest that the changes in rate and entrainment to the LFP observed in medium spiny neurons after dopamine depletion are somewhat dissociable, and that lack of D1- or D2-type receptor activation can exert independent yet interactive pathological effects during the progression of Parkinson's disease.
oscillations; Parkinson's disease; local field potentials; entrainment; movement; caudate; putamen
The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure
Stock, Jeffrey L.
Flannery, Patrick J.
Coffman, Thomas M.
McNeish, John D.
Audoly, Laurent P.
Journal of Clinical Investigation
The lipid mediator prostaglandin E2 (PGE2) has diverse biological activity in a variety of tissues. Four different receptor subtypes (EP1–4) mediate these wide-ranging effects. The EP-receptor subtypes differ in tissue distribution, ligand-binding affinity, and coupling to intracellular signaling pathways. To identify the physiological roles for one of these receptors, the EP1 receptor, we generated EP1-deficient (EP1–/–) mice using homologous recombination in embryonic stem cells derived from the DBA/1lacJ strain of mice. The EP1–/– mice are healthy and fertile, without any overt physical defects. However, their pain-sensitivity responses, tested in two acute prostaglandin-dependent models, were reduced by approximately 50%. This reduction in the perception of pain was virtually identical to that achieved through pharmacological inhibition of prostaglandin synthesis in wild-type mice using a cyclooxygenase inhibitor. In addition, systolic blood pressure is significantly reduced in EP1 receptor–deficient mice and accompanied by increased renin-angiotensin activity, especially in males, suggesting a role for this receptor in cardiovascular homeostasis. Thus, the EP1 receptor for PGE2 plays a direct role in mediating algesia and in regulation of blood pressure.
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