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Acta Crystallographica Section F: Structural Biology and Crystallization Communications (1)
Journal of Veterinary Science (1)
Yu, Xiaoping (2)
Chen, Wei (1)
Cheng, Daomei (1)
Fu, Tong-Jen (1)
Guo, Feng (1)
Howard, Andrew J. (1)
Jia, Hao (1)
Kothary, Mahendra H. (1)
Li, Shuai (1)
Liao, Jiru (1)
Liu, Hong (1)
Liu, Longjian (1)
Liu, Weihua (1)
Mi, Mantian (1)
Wang, Yang (1)
Wu, Xiuhua (1)
Zhang, Yu-Zhu (1)
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Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-κB/Caspase-1 pathway in Sprague-Dawley Rats
Journal of Veterinary Science
The effects of black rice anthocyanidins (BRACs) on retinal damage induced by photochemical stress are not well known. In the present study, Sprague-Dawley rats were fed AIN-93M for 1 week, after which 80 rats were randomly divided into two groups and treated with (n = 40) or without BRACs (n = 40) for 15 days, respectively. After treatment, both groups were exposed to fluorescent light (3,000 ± 200 lux; 25℃), and the protective effect of dietary BRACs were evaluated afterwards. Our results showed that dietary BRACs effectively prevented retinal photochemical damage and inhibited the retinal cells apoptosis induced by fluorescent light (p < 0.05). Moreover, dietary BRACs inhibited expression of AP-1 (c-fos/c-jun subunits), up-regulated NF-κB (p65) expression and phosphorylation of IκB-α, and decreased Caspase-1 expression (p < 0.05). These results suggest that BRACs improve retinal damage produced by photochemical stress in rats via AP-1/NF-κB/Caspase-1 apoptotic mechanisms.
apoptosis; black rice anthocyanidins; Caspase-1; photochemical damage; retina
Purification and crystallization of Cor a 9, a major hazelnut allergen
Kothary, Mahendra H.
Howard, Andrew J.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
The major hazelnut allergen Cor a 9 was purified from the natural source and crystallized. Diffraction data were collected to 1.9 Å resolution using a synchrotron-radiation source.
Hazelnut (Corylus avellana) is one of the food sources that induce allergic reaction in a subpopulation of people with food allergy. The 11S legumin-like seed-storage protein from hazelnut has been identified as one of the major hazelnut allergens and named Cor a 9. In this study, Cor a 9 was extracted from hazelnut kernels using a high-salt solution and was purified by desalting out and FPLC to a highly purified state. Diffraction-quality single crystals were obtained using the hanging-drop vapour-diffusion method. Diffraction data were collected and a structure solution has been obtained by molecular-replacement calculations. Further refinement of the structure is currently in progress.
hazelnuts; 11S seed-storage proteins; food allergies; tree-nut allergens
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