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Clinical Medicine Insights. Oncology (1)
World Journal of Surgical Oncology (1)
Mizunuma, Hideki (2)
Yokoyama, Yoshihito (2)
Abe, Kazuhiro (1)
Matsumura, Yukiko (1)
Tamura, Ryousuke (1)
Taniguchi, Ryousuke (1)
Tsuchida, Shigeki (1)
Wang, Hui (1)
Yanagita, Takeshi (1)
Year of Publication
Presentation of two patients with malignant granulosa cell tumors, with a review of the literature
World Journal of Surgical Oncology
Granulosa cell tumors (GCTs) of the ovary account for 2 to 5 of ovarian malignancies. We present two patients with malignant ovarian adult GCT. In one patient, a combination of bleomycin, etoposide, and cisplatin was effective after initial surgery for malignant GCT. In the other, an aromatase inhibitor was effective for recurrent malignant GCT. We also review the literature for further management of this tumor. Because GCT of the ovary is rare, it will be necessary to elucidate the clinical phenotype and establish treatment protocols by accumulating and analyzing more patients.
Ovarian malignant granulosa cell tumor; BEP combination therapy; Aromatase inhibitor
Malignant Ovarian Tumors with Induced Expression of Carbonyl Reductase Show Spontaneous Regression
Clinical Medicine Insights. Oncology
The present study investigated tumor proliferation in a tumor model using murine ovarian cancer cells with increased carbonyl reductase (CR) expression.
CR cDNA was transfected into murine T-Ag-MOSE ovarian cancer cells by lipofection. CR-transfected cells (CR induction group) or empty vector-treated cells (control group) were injected into the backs of 8-week-old nude mice at a concentration of 0.5 × 106 per 0.2 mL. Subsequent tumor proliferation in both groups was observed for 5 weeks.
The control group showed an increase in tumor volume during the 5 weeks of observation. However, tumor volume in the CR induction group increased up to the second week but then decreased continuously until the fifth week of observation. The tumor growth curves for the two groups showed a significant difference (Mann-Whitney U test, P < 0.001). Histological and biochemical experiments were performed using tumor tissues isolated in the third week. Necrosis and inflammatory cell infiltration were noted for tumors in the CR induction group. Also, the number of apoptotic cells was significantly increased in the CR induction group compared with the control group (P < 0.001). Milk fat globule EGF factor 8, an “eat-me” signal for phagocytes such as macrophages, was expressed extensively in the tumor cytoplasm and interstitial cells of the CR induction group, and engulfment of apoptotic cells by macrophages was observed. Vascular endothelial growth factor expression in tumors was notably decreased in the CR induction group compared with the control group.
Increased necrosis due to engulfing of apoptotic cells by phagocytes attracted by increased milk fat globule EGF factor 8 was considered to be the mechanism of spontaneous tumor regression in the CR induction group.
apoptosis; carbonyl reductase; ovarian tumor; phagocytosis
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