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Annals of epidemiology (1)
International journal of psychophysiology : official journal of the International Organization of Psychophysiology (1)
Menopause (New York, N.Y.) (1)
Vuga, Marike (3)
Cauley, Jane A. (1)
Cohn, Jeffrey F. (1)
Crandall, Carolyn (1)
Crawford, Sybil L. (1)
Fox, Nathan A. (1)
George, Charles J. (1)
Greendale, Gail (1)
Habel, Laurel A. (1)
Kovacs, Maria (1)
Lasley, Bill (1)
Laughlin, Gail A. (1)
McConnell, Daniel (1)
Modugno, Francesmary (1)
Ness, Roberta B. (1)
Polotsky, Alex J. (1)
Reeves, Katherine W. (1)
Santoro, Nanette (1)
Stone, Roslyn A. (1)
Vogel, Victor G. (1)
Weissfeld, Joel L. (1)
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Circulating Dehydroepiandrosterone Sulfate Levels in Women with Bilateral Salpingo-Oophorectomy during the Menopausal Transition
Crawford, Sybil L.
Laughlin, Gail A.
Polotsky, Alex J.
Menopause (New York, N.Y.)
A rise in circulating dehydroepiandrosterone sulfate (DHEAS) concentration occurs during the menopausal transition (MT) that is ovarian-stage but not age-related. The objective of this study was to determine the source of the rise in circulating DHEAS.
Circulating DS concentrations in women that had undergone bilateral salpingo-oophorectomy (BSO) were compared to the pattern of circulating DHEAS in women that progressed through the MT naturally. Annual serum samples from the Study of Women's Health Across the Nation (SWAN) over a ten year study period were used. From1272 women in the SWAN cohort that were eligible for longitudinal evaluation of DHEAS annual samples, eighty one underwent BSO during the pre- or early-perimenopause stage of the menopausal transition and were potentially available for study. Of these eighty one BSO participants, twenty had sufficient annual samples for evaluation of the post-BSO trajectory of circulating DHEAS. SWAN women not having previous hormone replacement therapy those with intact ovaries were compared to women that underwent a BSO immediately after a pre- or early perimenopausal annual visit. There were no intervention and circulating concentrations of DHEAS was the main outcome.
A detectable rise in DHEAS was observed in fourteen (70%) of the twenty BSO women which is similar to the proportion (85%) of women with intact ovaries that had a detectable DHEAS rise. The mean rise in DHEAS (5-8%) was similar in both BSO and non-BSO women.
The MT rise in DHEAS (5-8%) occurring in the absence of ovaries is largely of adrenal origin.
Dehydroepiandrosterone sulfate; menopause; adrenal; ovary
A Method to Estimate Off-Schedule Observations in a Longitudinal Study
Reeves, Katherine W.
Stone, Roslyn A.
Ness, Roberta B.
Vogel, Victor G.
Weissfeld, Joel L.
Habel, Laurel A.
Cauley, Jane A.
Annals of epidemiology
Data in epidemiological studies sometimes are collected off-schedule from planned study visits. In an ancillary study to the Study of Women's Health Across the Nation (SWAN), longitudinal breast density data were collected retrospectively from mammograms that were not acquired at the study visits. We propose a method to estimate the off-schedule breast density measurements at the time of study visits.
This method uses local linear interpolation, withmultiply imputed error terms drawn from assumed subject-specific normal distributions based on the within-subject standard deviations of mammographic density measurements. We evaluate the validity and implications of this approach.
Coefficients of random intercept models assessing the association between annual changes in body mass index and dense breast area estimated with this approach (β=-0.17, P=0.46) differed from those obtained when each mammogram was matched to the nearest study visit (β=-0.30, P=0.04). The proposed estimation approach had a small average prediction error (0.11 cm2).
Because matching does not incorporatebreast density changes over time, ourlocal linear interpolation with multiple imputation approach may provide more accurate results. The proposed approach is applicable to other epidemiologic studies with off-schedule data where the missing variable changes linearly over relatively short periods of time.
Epidemiologic Methods; Missing Data; Multiple Imputation; Linear Interpolation; Mammography
Long-Term Stability of Electroencephalographic Asymmetry and Power in 3 to 9 Year Old Children
Fox, Nathan A.
Cohn, Jeffrey F.
George, Charles J.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
We investigated test-retest stability of resting EEG asymmetry and power in the alpha frequency range across a 0.6 - to 3-year interval in 125 children (57 girls and 68 boys) for two age groups, 87 preschool children (3 to 5 year-olds) and 38 school-age children (6 to 9 year-olds). Children were from families with a parent’s history of unipolar or bipolar depression (36 girls and 43 boys) or control families with no parent history of depression nor any other psychiatric disorder (21 girls and 25 boys). Frontal EEG asymmetry stability was low to moderate; intraclass correlations ranged from zero to 0.48 in the eyes-open condition, and from 0.19 to 0.45 in the eyes-closed condition. Also, parietal EEG asymmetry was low to moderate; intraclass correlations ranged from 0.21 to 0.52 in the eyes-open condition and from 0.27 to 0.72 in the eyes-closed condition. Stability of EEG asymmetry was not related to age, sex of the child, or parent’s history of mood disorder. Frontal and parietal EEG power appeared moderately to highly stable. Intraclass correlations were between 0.65 and 0.86 in the eyes-open condition and between 0.52 and 0.90 in the eyes-closed condition. Although stability of EEG power was not statistical significantly different between preschool and school-age children, it consistently showed higher stability values in school-age children than in preschool children. Stability in school-aged children approached values as has been reported for adults. The findings provide partial support to the concept of frontal EEG asymmetry as a trait marker in childhood.
Stability; longitudinal study; EEG asymmetry; EEG power; development; sex; depression
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