Search tips
Search criteria

Results 1-25 (28)

Clipboard (0)

Select a Filter Below

more »
Year of Publication
Document Types
1.  A New Approach to Quantify Trabecular Resorption Adjacent to Cemented Knee Arthroplasty 
Journal of Biomechanics  2012;45(4):711-715.
A new micro-computed tomography (μCT) image processing approach to estimate the loss of cement-bone interlock was developed using the concept that PMMA cement flows and cures around trabeculae during the total knee arthroplasty procedure. The initial mold shape of PMMA cement was used to estimate the amount of interdigitated bone at the time of implantation and following in vivo service using enbloc human postmortem retrievals. Laboratory prepared specimens, where there would be no biological bone resorption, were used as controls to validate the approach and estimate errors. The image processing technique consisted of identifying bone and cement from the μCT scan set, dilation of the cement to identify the cement cavity space, and Boolean operations to identify the different components of the interdigitated cement-bone regions. For laboratory prepared specimens, there were small errors in the estimated resorbed bone volume fraction (reBVfr = 0.11±0.09) and loss in contact area fraction (CAfr = 0.06±0.15). These values would be zero if there were no error in the method. For the postmortem specimens, the resorbed volume fraction (reBVfr = 0.85±0.16) was large, meaning that only 15% of the cement mold shape was still filled with bone. The loss of contact area fraction (CAfr = 0.84±0.17) was similarly large. This new approach provides a convenient method to visualize and quantify trabecular bone loss from interdigitated regions from postmortem retrievals. The technique also illustrates for the first time that there are dramatic changes in how bone is fixed to cement following in vivo service.
PMCID: PMC3278511  PMID: 22227315
2.  Morphology Based Cohesive Zone Modeling of the Cement-Bone Interface from Postmortem Retrievals 
In cemented total hip arthroplasty, the cement-bone interface can be considerably degenerated after less than one year in-vivo service; this makes the interface much weaker relative to the direct post-operative situation. It is, however, still unknown how these degenerated interfaces behave under mixed-mode loading and how this is related to the morphology of the interface. In this study, we used a finite element approach to analyze the mixed-mode response of the cement-bone interface taken from postmortem retrievals and we investigated whether it was feasible to generate a fully elastic and a failure cohesive model based on only morphological input parameters.
Computed tomography-based finite element analysis models of the postmortem cement-bone interface were generated and the interface morphology was determined. The models were loaded until failure in multiple directions by allowing cracking of the bone and cement components and including periodic boundary conditions. The resulting stiffness was related to the interface morphology. A closed form mixed-mode cohesive model that included failure was determined and related to the interface morphology.
The responses of the finite element simulations compare satisfactorily with experimental observations, albeit the magnitude of the strength and stiffness are somewhat overestimated. Surprisingly, the finite element simulations predict no failure under shear loading and a considerable normal compression is generated which prevents dilation of the interface. The obtained mixed-mode stiffness response could subsequently be related to the interface morphology and subsequently be formulated into an elastic cohesive zone model. Finally, the acquired data could be used as an input for a cohesive model that also includes interface failure.
PMCID: PMC3143371  PMID: 21783159
finite element; bone; bone cement; interface; cohesive modeling
3.  Differences in the stress distribution in the distal femur between patellofemoral joint replacement and total knee replacement: a finite element study 
Patellofemoral joint replacement is a successful treatment option for isolated patellofemoral osteoarthritis. However, results of later conversion to total knee replacement may be compromised by periprosthetic bone loss. Previous clinical studies have demonstrated a decrease in distal femoral bone mineral density after patellofemoral joint replacement. It is unclear whether this is due to periprosthetic stress shielding. The main objective of the current study was to evaluate the stress shielding effect of prosthetic replacement with 2 different patellofemoral prosthetic designs and with a total knee prosthesis.
We developed a finite element model of an intact patellofemoral joint, and finite element models of patellofemoral joint replacement with a Journey PFJ prosthesis, a Richards II prosthesis, and a Genesis II total knee prosthesis. For each of these 4 finite element models, the average Von Mises stress in 2 clinically relevant regions of interest were evaluated during a simulated squatting movement until 120 degrees of flexion.
During deep knee flexion, in the anterior region of interest, the average Von Mises stress with the Journey PFJ design was comparable to the physiological knee, while reduced by almost 25% for both the Richards II design and the Genesis II total knee joint replacement design. The average Von Mises stress in the supracondylar region of interest was similar for both patellofemoral prosthetic designs and the physiological model, with slightly lower stress for the Genesis II design.
Patellofemoral joint replacement results in periprosthetic stress-shielding, although to a smaller degree than in total knee replacement. Specific patellofemoral prosthetic design properties may result in differences in femoral stress shielding.
PMCID: PMC3471009  PMID: 22704638
Patellofemoral joint replacement; Knee prosthesis; Finite element analysis; Stress shielding; Squat movement
4.  Interface micromechanics of transverse sections from retrieved cemented hip reconstructions: an experimental and finite element comparison 
In finite element analysis (FEA) models of cemented hip reconstructions, it is crucial to include the cement–bone interface mechanics. Recently, a micromechanical cohesive model was generated which reproduces the behavior of the cement–bone interface. The goal was to investigate whether this cohesive model was directly applicable on a macro level. From transverse sections of retrieved cemented hip reconstructions, two FEA-models were generated. The cement–bone interface was modeled with cohesive elements. A torque was applied and the cement–bone interface micromotions, global stiffness and stem translation were monitored. A sensitivity analysis was performed to investigate whether the cohesive model could be improved. All results were compared with experimental findings. That the original cohesive model resulted in a too compliant macromechanical response; the motions were too large and the global stiffness too small. When the cohesive model was modified, the match with the experimental response improved considerably.
PMCID: PMC3400762  PMID: 22678039
5.  Multi-axial Loading Micromechanics of the Cement-Bone Interface in Post-Mortem Retrievals and Lab-Prepared Specimens 
Maintaining adequate fixation between cement and bone is important for successful long term survival of cemented total joint replacements. Mixed-mode loading conditions (combination of tension/compression and shear) are present during in vivo loading, but the micromotion response of the interface to these conditions is not fully understood.
Non-destructive, multi-axial loading experiments were conducted on laboratory prepared (n=6) and post mortem (n=6) human cement-bone interfaces. Specimens were mounted in custom loading discs and loaded at 0, 30, 60, and 90° relative to the interface plane where 0° represents normal loading to the interface, and 90° represents shear loading along the longitudinal axis of the femur. Axial compliance did not depend on loading angle for laboratory prepared (p=0.96) or postmortem specimens (p=0.62). The cement-bone interface was more compliant under tensile than compressive loading at the 0° loading angle only (p=0.024). The coupled transverse to axial compliance ratio, which is a measure of the coupled motion, was small for laboratory prepared (0.115±0.115) and postmortem specimens (0.142±0.101). There was a moderately strong inverse relationship between interface compliance and contact index (r2 = 0.65).
From a computational modeling perspective, the results of the current study support the concept that the cement-bone interface could be numerically implemented as a compliant layer with the same initial stiffness in tension and shear directions. The magnitude of the compliance could be modified to simulate immediate post-operative conditions (using laboratory prepared data set) or long-term remodeling (using postmortem data set).
PMCID: PMC3077568  PMID: 21316624
6.  The behavior of the micro-mechanical cement-bone interface affects the cement failure in total hip replacement 
Journal of biomechanics  2010;44(2):228-234.
In the current study, the effects of different ways to implement the complex micro-mechanical behavior of the cement-bone interface on the fatigue failure of the cement mantle was investigated. In an FEA-model of a cemented hip reconstruction the cement-bone interface was modeled and numerically implemented in four different ways: (I) as infinitely stiff, (II) as infinitely strong with a constant stiffness, (III) a mixed-mode failure response with failure in tension and shear, and (IV) realistic mixed mode behavior obtained from micro FEA-models. Case II, III and IV were analyzed using data from a stiff and a compliant micro-FEA model and their effects on cement failure were analyzed. The data used for Case IV was derived from experimental specimens that were tested previously. Although the total number of cement cracks was low for all cases, the compliant Case II resulted in twice as many cracks as Case I. All cases caused similar stress distributions at the interface. In all cases, the interface did not display interfacial softening; all stayed the elastic zone. Fatigue failure of the cement mantle resulted in a more favorable stress distribution at the cement-bone interface in terms of less tension and lower shear tractions. We conclude that immediate cement-bone interface failure is not likely to occur, but its local compliancy does affect the formation of cement cracks. This means that at a macro-level the cement-bone interface should be modeled as a compliant layer. However, implementation of interfacial post-yield softening does seem to be necessary.
PMCID: PMC3019267  PMID: 21036358
Finite element; fatigue; bone; bone cement; interface
7.  Similar TKA designs with differences in clinical outcome 
Acta Orthopaedica  2011;82(6):685-691.
Background and purpose
To try to improve the outcome of our TKAs, we started to use the CKS prosthesis. However, in a retrospective analysis this design tended to give worse results. We therefore conducted a randomized, controlled trial comparing this CKS prosthesis and our standard PFC prosthesis. Because many randomized studies between different TKA concepts generally fail to show superiority of a particular design, we hypothesized that these seemingly similar designs would not lead to any difference in clinical outcome.
Patients and methods
82 patients (90 knees) were randomly allocated to one or other prosthesis, and 39 CKS prostheses and 38 PFC prostheses could be followed for mean 5.6 years. No patients were lost to follow-up. At each follow-up, patients were evaluated clinically and radiographically, and the KSS, WOMAC, VAS patient satisfaction scores and VAS for pain were recorded.
With total Knee Society score (KSS) as primary endpoint, there was a difference in favor of the PFC group at final follow-up (p = 0.04). Whereas there was one revision in the PFC group, there were 6 revisions in the CKS group (p = 0.1). The survival analysis with any reoperation as endpoint showed better survival in the PFC group (97% (95% CI: 92–100) for the PFC group vs. 79% (95% CI: 66–92) for the CKS group) (p = 0.02).
Our hypothesis that there would be no difference in clinical outcome was rejected in this study. The PFC system showed excellent results that were comparable to those in previous reports. The CKS design had differences that had considerable negative consequences clinically. The relatively poor results have discouraged us from using this design.
PMCID: PMC3247886  PMID: 22066559
8.  The effect of cement creep and cement fatigue damage on the micromechanics of the cement-bone interface 
Journal of biomechanics  2010;43(15):3028-3034.
The cement-bone interface provides fixation for the cement mantle within the bone. The cement-bone interface is affected by fatigue loading in terms of fatigue damage, or micro cracks, and creep, both mostly in the cement. This study investigates how fatigue damage and cement creep separately affect the mechanical response of the cement-bone interface at various load levels in terms of plastic displacement and crack formation. Two FEA models were created, which were based on micro-computed tomography data of two physical cement-bone interface specimens. These models were subjected to tensile fatigue loads with four different magnitudes. Three deformation modes of the cement were considered; ‘only creep’, ‘only damage’ or ‘creep and damage’. The interfacial plastic deformation, the crack reduction as a result of creep and the interfacial stresses in the bone were monitored. The results demonstrate that, although some models failed early, the majority of plastic displacement was caused by fatigue damage, rather than cement creep. However, cement creep does decrease the crack formation in the cement up to 20%. Finally, while cement creep hardly influences the stress levels in the bone, fatigue damage of the cement considerably increases the stress levels in the bone. We conclude that at low load levels the plastic displacement is mainly caused by creep. At moderate to high load levels, however, the plastic displacement is dominated by fatigue damage and is hardly affected by creep, although creep reduced the number of cracks in moderate to high load region.
PMCID: PMC2975749  PMID: 20692663
Finite element; fatigue; bone; bone cement; interface
9.  Evaluation of subsidence, chondrocyte survival and graft incorporation following autologous osteochondral transplantation 
The aim of this study was to evaluate subsidence tendency, surface congruency, chondrocyte survival and plug incorporation after osteochondral transplantation in an animal model. The potential benefit of precise seating of the transplanted osteochondral plug on the recipient subchondral host bone (‘bottoming’) on these parameters was assessed in particular.
In 18 goats, two osteochondral autografts were harvested from the trochlea of the ipsilateral knee joint and inserted press-fit in a standardized articular cartilage defect in the medial femoral condyle. In half of the goats, the transplanted plugs were matched exactly to the depth of the recipient hole (bottomed plugs; n = 9), whereas in the other half of the goats, a gap of 2 mm was left between the plugs and the recipient bottom (unbottomed plugs; n = 9). After 6 weeks, all transplants were evaluated on gross morphology, subsidence, histology, and chondrocyte vitality.
The macroscopic morphology scored significantly higher for surface congruency in bottomed plugs as compared to unbottomed reconstructions (P = 0.04). However, no differences in histological subsidence scoring between bottomed and unbottomed plugs were found. The transplanted articular cartilage of both bottomed and unbottomed plugs was vital. Only at the edges some matrix destaining, chondrocyte death and cluster formation was observed. At the subchondral bone level, active remodeling occurred, whereas integration at the cartilaginous surface of the osteochondral plugs failed to occur. Subchondral cysts were found in both groups.
In this animal model, subsidence tendency was significantly lower after ‘bottomed’ versus ‘unbottomed’ osteochondral transplants on gross appearance, whereas for histological scoring no significant differences were encountered. Since the clinical outcome may be negatively influenced by subsidence, the use of ‘bottomed’ grafts is recommended for osteochondral transplantation in patients.
PMCID: PMC3199551  PMID: 21904953
Autologous osteochondral transplantation; Osteochondral defect; Cartilage repair; Cartilage defect; Histology
10.  The effect of impaction and a bioceramic coating on bone ingrowth in porous titanium particles 
Acta Orthopaedica  2011;82(3):372-377.
Background and purpose
Porous titanium (Ti) particles can be impacted like cancellous allograft bone particles, and may therefore be used as bone substitute in impaction grafting. We evaluated the effect of impaction and of a thin silicated biphasic calcium phosphate coating on osteoconduction by Ti particles.
The bone conduction chamber of Aspenberg was used in goats and filled with various groups of coated or uncoated small Ti particles (diameter 1.0–1.4 mm). Impacted allograft bone particles and empty chambers were used in control groups. Fluorochromes were administered at 4, 8, and 12 weeks. Maximum bone ingrowth distance was evaluated by histomorphometric analysis.
Histology of Ti particle graft cylinders showed a dense matrix with narrow inter-particle and intra-particle pores (< 100 μm), occluding the lumen of the bone chamber. Bone ingrowth distances gradually increased with time in all groups. Maximum bone ingrowth distance was higher in originally empty chambers than those with allograft bone particles (p = 0.01) and Ti particles (p < 0.001). Maximum bone ingrowth in allograft bone particles was higher than in all Ti groups (p ≤ 0.001). Impaction reduced osteoconduction and the coating partially compensated for the negative effect of impaction, but these differences were not statistically significant. No osteolytic reactions were found.
Osteoconduction in the bone conduction chamber was reduced more by the insertion of small Ti particles than by insertion of small allograft bone particles. The osteoconductive potential of porous Ti particles should be studied further with larger-sized particles, which may allow bone ingrowth after impaction through larger inter-particle pores.
PMCID: PMC3235319  PMID: 21504310
11.  The mechanical effects of different levels of cement penetration at the cement-bone interface 
Journal of biomechanics  2010;43(6):1167-1175.
The mechanical effects of varying the depth of cement penetration in the cement-bone interface was investigated using finite element analysis (FEA) and validated using companion experimental data. Two FEA models of the cement-bone interface were created from microcomputed tomography data and the penetration of cement into the bone was varied over six levels each. The FEA models, consisting of the interdigitated cement-bone constructs with friction between cement and bone, were loaded to failure in tension and in shear. The cement and bone elements had provision for crack formation due to excessive stress. The interfacial strength showed a strong relationship with the average interdigitation (r2=0.97 and r2=0.93 in tension and shear, respectively). Also, the interface strength was strongly related with the contact area (r2=0.98 and r2=0.95 in tension and shear, respectively). The FEA results compared favorably to the stiffness-strength relationships determined experimentally. Overall, the cement-bone interface was 2.5 times stronger in shear than in tension and 1.15 times stiffer in tension than in shear, independent of the average interdigitation. More cracks occurred in the cement than in the bone, independent of the average interdigitation, consistent with the experimental results. In addition, more cracks were generated in shear than in tension. In conclusion, achieving and maintaining maximal infiltration of cement into the bone to obtain large interdigitation and contact area is key to optimizing the interfacial strength.
PMCID: PMC2849873  PMID: 20022010
bone; bone cement; interface; finite element; mechanics
12.  Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures 
The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth was analyzed by a push out test. Histomorphometry was performed to assess the bone ingrowth depth and bone implant contact. The uncoated and hydroxyapatite-coated cubic structure had significantly higher mechanical strength at the interface compared to the Ti plasma spray coating at 15 weeks of implantation. Bone ingrowth depth was significantly larger for the hydroxyapatite- and brushite-coated structures compared to the uncoated structure. In conclusion, the porous E-beam surface structure showed higher bone ingrowth potential compared to a conventional implant surface after 15 weeks of implantation. Addition of a calcium phosphate coating to the E-beam structure enhanced bone ingrowth significantly. Furthermore, the calcium phosphate coating appears to work as an accelerator for bone ingrowth.
PMCID: PMC3085057  PMID: 21327405
13.  Frictional and bone ingrowth properties of engineered surface topographies produced by electron beam technology 
Electron beam melting (E-beam) is a new technology to produce 3-dimensional surface topographies for cementless orthopedic implants.
The friction coefficients of two newly developed E-beam produced surface topographies were in vitro compared with sandblasted E-beam and titanium plasma sprayed controls. Bone ingrowth (direct bone–implant contact) was determined by implanting the samples in the femoral condyles of 6 goats for a period of 6 weeks.
Friction coefficients of the new structures were comparable to the titanium plasma sprayed control. The direct bone–implant contact was 23.9 and 24.5% for the new surface structures. Bone–implant contact of the sandblasted and titanium plasma sprayed control was 18.2 and 25.5%, respectively.
The frictional and bone ingrowth properties of the E-beam produced surface structures are similar to the plasma-sprayed control. However, since the maximal bone ingrowth had not been reached for the E-beam structures during the relatively short-term period, longer-term follow-up studies are needed to assess whether the E-beam structures lead to a better long-term performance than surfaces currently in use, such as titanium plasma spray coating.
PMCID: PMC3078515  PMID: 21161665
Electron beam melting; Bone ingrowth; Friction; Surface characteristics; Prosthesis
14.  Fatigue creep damage at the cement-bone interface: an experimental and a micro-mechanical finite element study 
Journal of biomechanics  2009;42(15):2513-2519.
The goal of this study was to quantify the micromechanics of the cement-bone interface under tensile fatigue loading using finite element analysis (FEA) and to understand the underlying mechanisms that play a role in the fatigue behavior of this interface. Laboratory cement-bone specimens were subjected to a tensile fatigue load, while local displacements and crack growth on the specimen's surface were monitored. FEA models were created from these specimens based upon micro-computed tomography data. To accurately model interfacial gaps at the interface between the bone and cement, a custom-written erosion algorithm was applied to the bone model. A fatigue load was simulated in the FEA models while monitoring the local displacements and crack propagation. The results showed the FEA models were able to capture the general experimental creep damage behavior and creep stages of the interface. Consistent with the experiments, the majority of the deformation took place at the contact interface. Additionally, the FEA models predicted fatigue crack patterns similar to experimental findings. Experimental surface cracks correlated moderately with FEA surface cracks (r2=0.43), but did not correlate with the simulated crack volume fraction (r2=0.06). Although there was no relationship between experimental surface cracks and experimental creep damage displacement (r2=0.07), there was a strong relationship between the FEA crack volume fraction and the FEA creep damage displacement (r2=0.76). This study shows the additional value of FEA of the cement-bone interface relative to experimental studies and can therefore be used to optimize its mechanical properties.
PMCID: PMC2783955  PMID: 19682690
bone; bone cement; interface; finite element; damage
15.  Posterior cruciate ligament recruitment affects antero-posterior translation during flexion gap distraction in total knee replacement 
Acta Orthopaedica  2010;81(4):471-477.
Background and purpose
Because of the oblique orientation of the posterior cruciate ligament (PCL), flexion gap distraction could lead to anterior movement of the tibia, which would influence the tibiofemoral contact point. This would affect the kinematics of the TKR. We assessed the flexion gap parameters when the knee is distracted during implantation of a PCL-retaining TKR. Furthermore, the effects of PCL elevation (steep or flat) and collateral ligament releases on the flexion gap parameters were determined.
During a ligament-guided TKR procedure in 50 knees, the flexion gap was distracted with a double-spring tensor with 200N after the tibia had been cut. The flexion gap height, anterior tibial translation, and femoral rotation were measured intraoperatively using a CT-free navigation system.
During flexion gap distraction, the greatest displacement was seen in anterior-posterior direction. Mean ratio between increase in gap height and tibial translation was 1 to 1.9, and was highest for knees with a steep PCL (1 to 2.3). Knees with a flat PCL and knees with a ligament release had a larger increase in PCL elevation when the gap was distracted.
When the PCL is tensioned, every extra mm that the flexion gap is distracted can be expected to move the tibia anteriorly by at least 1.7 mm (flat PCL), or more if there is a steep PCL. This changes the tibiofemoral contact point, which may have consequences for polyethylene wear.
PMCID: PMC2917571  PMID: 20809745
16.  Functional interface micromechanics of 11 en-bloc retrieved cemented femoral hip replacements 
Acta Orthopaedica  2010;81(3):308-317.
Background and purpose
Despite the longstanding use of micromotion as a measure of implant stability, direct measurement of the micromechanics of implant/bone interfaces from en bloc human retrievals has not been performed. The purpose of this study was to determine the stem-cement and cement-bone micromechanics of functionally loaded, en-bloc retrieved, cemented femoral hip components.
11 fresh frozen proximal femurs with cemented implants were retrieved at autopsy. Specimens were sectioned transversely into 10-mm slabs and fixed to a loading device where functional torsional loads were applied to the stem. A digital image correlation technique was used to document micromotions at stem-cement and cement-bone interfaces during loading.
There was a wide range of responses with stem-cement micromotions ranging from 0.0006 mm to 0.83 mm (mean 0.17 mm, SD 0.29) and cement-bone micromotions ranging from 0.0022 mm to 0.73 mm (mean 0.092 mm, SD 0.22). There was a strong (linear-log) inverse correlation between apposition fraction and micromotion at the stem-cement interface (r2 = 0.71, p < 0.001). There was a strong inverse log-log correlation between apposition fraction at the cement-bone interface and micromotion (r2 = 0.85, p < 0.001). Components that were radiographically well-fixed had a relatively narrow range of micromotions at the stem-cement (0.0006–0.057 mm) and cement-bone (0.0022–0.029 mm) interfaces.
Minimizing gaps at the stem-cement interface and encouraging bony apposition at the cement-bone interface would be clinically desirable. The cement-bone interface does not act as a bonded interface in actual use, even in radiographically well-fixed components. Rather, the interface is quite compliant, with sliding and opening motions between the cement and bone surfaces.
PMCID: PMC2876832  PMID: 20367421
17.  A sliding stem in revision total knee arthroplasty provides stability and reduces stress shielding 
Acta Orthopaedica  2010;81(3):337-343.
Background and purpose
In the reconstruction of unicondylar femoral bone defects with morselized bone grafts in revision total knee arthroplasty, a stem extension appears to be critical to obtain adequate mechanical stability. Whether stability is still assured by this reconstruction technique in bicondylar defects has not been assessed. The disadvantage of relatively stiff stem extensions is that bone resorption is promoted due to stress shielding. We therefore designed a stem that would permit axial sliding movements of the articulating part relative to the intramedullary stem.
This stem was used in the reconstruction with impaction bone grafting (IBG) of 5 synthetic distal femora with a bicondylar defect. A cyclically axial load was applied to the prosthetic condyles to assess the stability of the reconstruction. Radiostereometry was used to determine the migrations of the femoral component with a rigidly connected stem, a sliding stem, and no stem extension.
We found a stable reconstruction of the bicondylar femoral defects with IBG in the case of a rigidly connected stem. After disconnecting the stem, the femoral component showed substantially more migrations. With a sliding stem, rotational migrations were similar to those of a rigidly connected stem. However, the sliding stem allowed proximal migration of the condylar component, thereby compressing the IBG.
The presence of a functional stem extension is important for the stability of a bicondylar reconstruction. A sliding stem provides adequate stability, while stress shielding is reduced because compressive contact forces are still transmitted to the distal femoral bone.
PMCID: PMC2876836  PMID: 20450422
18.  Micro-mechanics of Post-mortem Retrieved Cement-Bone Interfaces 
The cement-bone interface plays an important role in load transfer between cemented implant systems and adjacent bone, but little is known about the micro-mechanical behavior of this interface following in vivo service. Small samples of post-mortem retrieved cement-bone specimens from cemented total hip replacements were prepared and mechanically loaded to determine the mechanical response to tensile and compressive loading. The morphology of the cement-bone interface was quantified using a CT-based stereology approach. Laboratory prepared specimens were used to represent immediate post-operative conditions for comparison. The stiffness and strength of the cement-bone interface from post-mortem retrievals was much lower than that measured from laboratory prepared specimens. The cement-bone interfaces from post-mortem retrievals were very compliant (under tension and compression) and had a very low tensile strength (0.21 ± 0.32 MPa). With a linear regression model, including interface contact fraction and intersection fraction between cement and bone could explain 71% (p<0.0001) of the variability in experimental response. Bony remodeling following an arthroplasty procedure may contribute to reduced contact between cement and bone and this is associated with weaker and more compliant interfaces.
PMCID: PMC2796700  PMID: 19658167
19.  Finite element simulation of cement-bone interface micromechanics; a comparison to experimental results 
Recently, experiments have been performed to determine the micromechanical behavior of the cement-bone interface under tension-compression loading conditions. These experiments were simulated using finite element analysis (FEA) to test whether the micromechanical response of the cement-bone interface could be captured in micro-models. Cement-bone interface models were created of experimental specimens based upon micro-computed tomography data, including the complex interdigitated bone-cement morphology and simulated frictional contact at the interface. The models were subjected to a fully reversible tension-compression load, mimicking the experimental protocol. Similar to what was found experimentally, the simulated interface was stiffer in compression than in tension and the majority of displacement localized to the cement-bone interface. There was a weak correlation between the FEA predicted stiffness and the stiffness found experimentally, with average errors of 8.3 and 29.8% in tension and compression, respectively. The hysteresis behavior found experimentally was partially reproduced in the simulation by including friction at the cement-bone interface. Furthermore, stress analysis suggested that cement was more at risk of fatigue failure than bone, concurring with the experimental observation that more cracks were formed in the cement than in the bone. The current study provides information that may help to better understand the load transfer mechanisms taking place at the cement-bone interface.
PMCID: PMC2802538  PMID: 19340877
bone; bone cement; interface; finite element
20.  Shear Fatigue Micromechanics of the Cement-Bone Interface: An in Vitro Study Using Digital Image Correlation Techniques 
Loss of fixation at cement-bone interface is known to contribute to aseptic loosening, but very little is known about the mechanical damage response of this interface. An in vitro study using cement-bone specimens subjected to shear fatigue loading was performed and the progression of stiffness and creep damage at the interface was measured using digital image correlation techniques. Stiffness and creep damage localized to the contact interface between cement and bone. Interface creep damage followed a three-phase response with an initial rapid increase in creep, followed by a steady state increase, concluding in a final rapid increase in creep. The initial creep phase was accompanied by an increase in interface stiffness suggesting that there was an initial locking-in affect at the interface. There was a decrease in interface stiffness as further creep damage progressed. Power law models were reasonably successful in describing the creep and stiffness damage response and were a function of loading magnitude, number of loading cycles, and contact area at the cement-bone interface. There was more micro-crack damage to the cement when compared to the bone and this localized along the interface. These findings indicate that damage to the cement-bone interface could be minimized by improving cement-bone contact and by strengthening the fatigue resistance of the cement.
PMCID: PMC2790035  PMID: 18846550
Aseptic loosening; joint replacement; micromechanics; interface mechanics; damage
21.  Micromechanical modeling of the cement-bone interface: the effect of friction, morphology and material properties on the micromechanical response 
Journal of biomechanics  2008;41(15):3158-3163.
In order to gain insight into the micro-mechanical behavior of the cement-bone interface, the effect of parametric variations of frictional, morphological and material properties on the mechanical response of the cement-bone interface were analyzed using a finite element approach. Finite element models of a cement-bone interface specimen were created from micro-computed tomography data of a physical specimen that was sectioned from an in vitro cemented total hip arthroplasty. In five models the friction coefficient was varied (μ= 0.0; 0.3; 0.7; 1.0 and 3.0), while in one model an ideally bonded interface was assumed. In two models cement interface gaps and an optimal cement penetration were simulated. Finally, the effect of bone cement stiffness variations was simulated (2.0 and 2.5 GPa, relative to the default 3.0 GPa). All models were loaded for a cycle of fully reversible tension-compression. From the simulated stress-displacement curves the interface deformation, stiffness and hysteresis were calculated. The results indicate that in the current model the mechanical properties of the cement-bone interface were caused by frictional phenomena at the shape-closed interlock rather than by adhesive properties of the cement. Our findings furthermore show that in our model maximizing cement penetration improved the micromechanical response of the cement-bone interface stiffness, while interface gaps had a detrimental effect. Relative to the frictional and morphological variations, variations in the cement stiffness had only a modest effect on the micromechanical behavior of the cement-bone interface. The current study provides information that may help to better understand the load transfer mechanisms taking place at the cement-bone interface.
PMCID: PMC2613656  PMID: 18848699
bone; bone cement; finite element; interface
22.  Finite element analysis of the effect of cementing concepts on implant stability and cement fatigue failure 
Acta Orthopaedica  2009;80(3):319-324.
Background and purpose Two contradictory cementing techniques (using an undersized stem versus a canal-filling stem) can both lead to excellent survival rates, a phenomenon known as the “French paradox”. Furthermore, previous studies have indicated that the type of bone supporting the cement mantle may affect implant survival. To further evaluate the mechanical consequences of variations in cementing technique, we studied the effect of implant size and type of bone supporting the cement mantle on the mechanical performance of cemented total hip arthroplasty, using finite element analysis.
Methods In a generic 2-dimensional plane-strain finite element model of a transverse section of a cemented total hip arthroplasty with a Charnley-Kerboull stem, we varied implant size and type of bone supporting the cement mantle. The models were subjected to 2 × 106 cycles of an alternating loading pattern of torque and a transverse load. During this loading history, we simulated cement fatigue crack formation and tracked rotational stability of the implant.
Results Canal-filling stems produced fewer cement cracks and less rotation than undersized stems. Cement mantles surrounded by trabecular bone produced more cement cracks and implant rotation than cement mantles surrounded by cortical bone.
Interpretation Our investigation provides a possible explanation for the good clinical results obtained with canal-filling Charnley-Kerboull implants. Our findings also indicate that inferior mechanical properties are obtained with these implants if the cement is supported by trabecular bone, which may be minimized by an optimal cementing technique.
PMCID: PMC2823222  PMID: 19421913
23.  In Vitro Testing of Femoral Impaction Grafting With Porous Titanium Particles: A Pilot Study 
The disadvantages of allografts to restore femoral bone defects during revision hip surgery have led to the search for alternative materials. We investigated the feasibility of using porous titanium particles and posed the following questions: (1) Is it possible to create a high-quality femoral graft of porous titanium particles in terms of graft thickness, cement thickness, and cement penetration? (2) Does this titanium particle graft layer provide initial stability when a femoral cemented stem is implanted in it? (3) What sizes of particles are released from the porous titanium particles during impaction and subsequent cyclic loading of the reconstruction? We simulated cemented revision reconstructions with titanium particles in seven composite femurs loaded for 300,000 cycles and measured stem subsidence. Particle release from the titanium particle grafts was analyzed during impaction and loading. Impacted titanium particles formed a highly interlocked graft layer. We observed limited cement penetration into the titanium particle graft. A total mean subsidence of 1.04 mm was observed after 300,000 cycles. Most particles released during impaction were in the phagocytable range (< 10 μm). There was no detectable particle release during loading. Based on the data, we believe titanium particles are a promising alternative for allografts. However, animal testing is warranted to investigate the biologic effect of small-particle release.
PMCID: PMC2674165  PMID: 19139968
24.  Is an Impacted Morselized Graft in a Cage an Alternative for Reconstructing Segmental Diaphyseal Defects? 
Large diaphyseal bone defects often are reconstructed with large structural allografts but these are prone to major complications. We therefore asked whether impacted morselized bone graft could be an alternative for a massive structural graft in reconstructing large diaphyseal bone defects. Defects in the femora of goats were reconstructed using a cage filled with firmly impacted morselized allograft or with a structural cortical autograft (n = 6 in both groups). All reconstructions were stabilized with an intramedullary nail. The goats were allowed full weightbearing. In all reconstructions, the grafts united radiographically. Mechanical torsion strength of the femur with the cage and structural cortical graft reconstructions were 66.6% and 60.3%, respectively, as compared with the contralateral femurs after 6 months. Histologically, the impacted morselized graft was replaced completely by new viable bone. In the structural graft group, a mixture of new and necrotic bone was present. Incorporation of the impacted graft into new viable bone suggests this type of reconstruction may be safer than reconstruction with a structural graft in which creeping substitution results in a mixture of viable and necrotic bone that can fracture. The data suggest that a cage filled with a loaded morselized graft could be an alternative for the massive cortical graft in reconstruction of large diaphyseal defects in an animal model.
PMCID: PMC2635451  PMID: 19142693
25.  A New Method to Make 2-D Wear Measurements Less Sensitive to Projection Differences of Cemented THAs 
Wear curves from individual patients often show unexplained irregular wear curves or impossible values (negative wear). We postulated errors of two-dimensional wear measurements are mainly the result of radiographic projection differences. We tested a new method that makes two-dimensional wear measurements less sensitive for radiograph projection differences of cemented THAs. The measurement errors that occur when radiographically projecting a three-dimensional THA were modeled. Based on the model, we developed a method to reduce the errors, thus approximating three-dimensional linear wear values, which are less sensitive for projection differences. An error analysis was performed by virtually simulating 144 wear measurements under varying conditions with and without application of the correction: the mean absolute error was reduced from 1.8 mm (range, 0–4.51 mm) to 0.11 mm (range, 0–0.27 mm). For clinical validation, radiostereometric analysis was performed on 47 patients to determine the true wear at 1, 2, and 5 years. Subsequently, wear was measured on conventional radiographs with and without the correction: the overall occurrence of errors greater than 0.2 mm was reduced from 35% to 15%. Wear measurements are less sensitive to differences in two-dimensional projection of the THA when using the correction method.
PMCID: PMC2505227  PMID: 18264857

Results 1-25 (28)